ChemicalBook >> CAS DataBase List >>1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro-

1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro-

1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro- structure

CAS No.: 1354030-19-5

Chemical Name:: 1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro-

Synonyms: UNC9975;UNC-9975;1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro-

CBNumber:: CB89278187

Molecular Formula:: C23H28Cl2N4O2

Molecular Weight:: 463.4

MDL Number:

MOL File:: 1354030-19-5.mol

Last updated:2025-12-05 14:33:18

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1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro- Properties

Boiling point	651.5±65.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
pka	8.68±0.10(Predicted)

1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro- Chemical Properties,Uses,Production

Description

UNC9975 is a novel β-arrestin-biased D2R agonist. UNC9975 is an analog of aripiprazole and is a β-arrestin–biased dopamine D2 receptor ligand. Functionally selective, β-arrestin-biased D(2)R ligands represent valuable chemical probes for further investigations of D(2)R signaling in health and disease.

Uses

UNC9975 is a D2R agonist that displays signaling bias via β-arrestin–ergic signaling and a simultaneously antagonist of Gi-regulated cAMP production and partial agonist for D2R/β-arrestin-2 interactions. UNC9975 can be utilized in antipsychotic research[1].

References

[1] Allen JA, et al. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18488-93. DOI:10.1073/pnas.1104807108

1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro- Preparation Products And Raw materials

Raw materials

Preparation Products

1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro- Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39035	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29257	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
TargetMol Chemicals Inc.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from 1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-05	UNC9975 1354030-19-5	US $293.00-987.00 / mg		98.78%	10g	TargetMol Chemicals Inc.

UNC9975
1354030-19-5
US $293.00-987.00 / mg
98.78%
TargetMol Chemicals Inc.

1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro- Spectrum

1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro-(1354030-19-5)¹HNMR

1,8-Naphthyridin-2(1H)-one, 7-[4-[4-(2,3-dichlorophenyl)hexahydro-1H-1,4-diazepin-1-yl]butoxy]-3,4-dihydro- UNC9975 UNC-9975 1354030-19-5