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Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI)

Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Structure
Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) structure
CAS No.
129540-12-1
Chemical Name:
Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI)
Synonyms
JNJ-7925476 free base;JNJ7925476 free base,JNJ 7925476 free base;Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI)
CBNumber:
CB89752816
Molecular Formula:
C20H19N
Molecular Weight:
273.37
MDL Number:
MOL File:
129540-12-1.mol
Last updated:2025-08-21 16:37:02
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Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Properties

Boiling point 403.3±33.0 °C(Predicted)
Density 1.16±0.1 g/cm3(Predicted)
pka 8.35±0.40(Predicted)
FDA UNII VSM44B5G3G

Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Chemical Properties,Uses,Production

Uses

JNJ-7925476 is a triple reuptake inhibitor that selectively and potently inhibits the activity of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). JNJ-7925476 is rapidly absorbed into the blood and its concentration in the brain is 7-fold higher than that in plasma. The occupancy ED(50) values of JNJ-7925476 for SERT, NET, and DAT in the rat brain are 0.18, 0.09, and 2.4 mg/kg, respectively. JNJ-7925476 rapidly induces a significant increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex in a dose-dependent manner. JNJ-7925476 exhibits potent antidepressant-like activity in the mouse tail suspension test. These results suggest that JNJ-7925476 has in vivo efficacy in biochemical and behavioral models of depression[1].

References

[1] In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor DOI:10.1016/j.ejphar.2008.04.008

Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19962 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29641 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58

View Lastest Price from Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JNJ-7925476 free base pictures 2025-08-21 JNJ-7925476 free base
129540-12-1
 US $1980.00-1520.00 / mg 10g TargetMol Chemicals Inc.
Pyrrolo[2,1-a]isoquinoline, 6-(4-ethynylphenyl)-1,2,3,5,6,10b-hexahydro-, trans- (9CI) JNJ-7925476 free base JNJ7925476 free base,JNJ 7925476 free base 129540-12-1