L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI)
![L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI) Structure](CAS/20211123/GIF/82188-90-7.gif)
- CAS No.
- 82188-90-7
- Chemical Name:
- L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI)
- Synonyms
- Ppack HCl;PPACK (hydrochloride);Fprmecl, dihydrochloride;L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI)
- CBNumber:
- CB910913953
- Molecular Formula:
- C21H32Cl2N6O3
- Molecular Weight:
- 487.43
- MDL Number:
- MOL File:
- 82188-90-7.mol
| Product description | Number | Pack Size | Price |
| PPACK, Dihydrochloride PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiomet | 520222 | 5 mg | $297 |
| PPACK, Dihydrochloride PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiomet | 520222 | 25 mg | $991 |
L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI) Properties
| solubility |
DMSO: Soluble Water: Soluble |
|---|---|
| FDA UNII | 5K09050P7Z |
L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 520222 | PPACK, Dihydrochloride PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiomet | 82188-90-7 | 5 mg | $297 | 2025-07-31 | Buy |
| Sigma-Aldrich | 520222 | PPACK, Dihydrochloride PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (Kobs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiomet | 82188-90-7 | 25 mg | $991 | 2025-07-31 | Buy |
L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI) Chemical Properties,Uses,Production
Uses
PPACK dihydrochloride is a plasminogen activator (rt-PA) inhibitor. PPACK dihydrochloride can inhibit changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin. PPACK dihydrochloride also inhibits the binding of rt-PA to plasma protease inhibitors[1].
References
[1] Mohler MA, et, al. D-Phe-Pro-Arg-chloromethylketone: its potential use in inhibiting the formation of in vitro artifacts in blood collected during tissue-type plasminogen activator thrombolytic therapy. Thromb Haemost. 1986 Oct 21;56(2):160-4. PMID:2433785
[2] S R HANSON L A H. Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketone.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1988, 85 9: 3184-3188. DOI: 10.1073/pnas.85.9.3184
[3] W BODE A K D Turk. The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.[J]. Protein Science, 1992, 1 4: 426-471. DOI: 10.1002/pro.5560010402
[4] ILDIKO M. KOVACH*. Proton Bridging in the Interactions of Thrombin with Small Inhibitors[J]. Biochemistry Biochemistry, 2009, 48 30: 7296-7304. DOI: 10.1021/bi900098s
[5] JU-FANG LIU. Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways.[J]. Arthritis Research & Therapy, 2012, 14 2: R91. DOI: 10.1186/ar3815
[6] M. LYON. D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK): alternative anticoagulant to heparin salts for blood gas and electrolyte specimens.[J]. Clinical chemistry, 1995, 41 7 1: 1038-1041. DOI: 10.1093/clinchem/41.7.1038
L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Shanghai Hanhong Scientific Co., Ltd. | +undefined17612118332 | Lucky@hanhonggroup.com | China | 5844 | 58 |
| Foshan Heshuo Pharm technology Co., ltd | 15363639686 | heshuoyiyao@hotmail.com | China | 2374 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29641 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Fuan Bio | 18178976185 | 3855357086@qq.com | China | 971 | 58 |
View Lastest Price from L-Prolinamide, D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-, dihydrochloride (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-08-21 | PPACK Dihydrochloride..
82188-90-7
|
US $0.00 / removed | 10g | TargetMol Chemicals Inc. |
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- PPACK Dihydrochloride..
82188-90-7
- US $0.00 / removed
- TargetMol Chemicals Inc.
