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Climazolam

Climazolam Structure
Climazolam structure
CAS No.
59467-77-5
Chemical Name:
Climazolam
Synonyms
Climazolam;Ro-21-3982;8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-chlorophenyl)-1-methyl-
CBNumber:
CB91178327
Molecular Formula:
C18H13Cl2N3
Molecular Weight:
342.22
MDL Number:
MFCD00867681
MOL File:
59467-77-5.mol
MSDS File:
SDS
Last updated:2023-09-11 16:43:46
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Climazolam Properties

Boiling point 522.7±60.0 °C(Predicted)
Density 1.38±0.1 g/cm3(Predicted)
pka 6.05±0.40(Predicted)
InChI InChI=1S/C18H13Cl2N3/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13/h2-9H,10H2,1H3
InChIKey CHCISLOJADQUNQ-UHFFFAOYSA-N
SMILES N12C(C)=NC=C1CN=C(C1=CC=CC=C1Cl)C1=CC(Cl)=CC=C12
FDA UNII O9KZB9HG1Y

Climazolam price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0011078 CLIMAZOLAM 95.00% 59467-77-5 5MG $502.96 2021-12-16 Buy
Product number Packaging Price Buy
API0011078 5MG $502.96 Buy

Climazolam Chemical Properties,Uses,Production

Description

Climazolam is a potent benzodiazepine which, following IV administration, has a very rapid onset of effect. It has a marketing authorization in Switzerland for use in dogs, but has been used in a wide variety of animals including cattle, sheep, horses and dogs (Rehm & Schatzmann, 1984). It is used as part of anaesthetic combinations. It is particularly effective for use with ketamine and, in horses, this combination has been used by constant rate infusion (CRI) to produce total intravenous anaesthesia (TIVA), the climazolam being reversed with sarmazenil (see below) at the end of surgery to produce a rapid recovery (BettschartWolfensberger et al., 1996). Climazolam (1.0–1.5 mg/kg) has also been used in combination with fentanyl (0.005–0.015 mg/kg) for anaesthesia in the dog (Erhardt et al., 1986).

Uses

Climazolam (Ro21-3982) was introduced under licence as a veterinary medicine by the Swiss Pharmaceutical company Gr?ub under the tradename Climasol. Climazolam is a benzodiazepine, specifically an imidazobenzodiazepine derivative developed by Hoffman-LaRoche. It is similar in structure to midazolam and diclazepam and is used in veterinary medicine for anesthetizing animals.

Indications

Climazolam: an injectable benzodiazepine approved in Europe for anesthesia in dogs and cats, for example, as premedication with an opioid or for induction with ketamine.
Climazolam is a possible alternative to midazolam, but its use will require a relaxing of the import regulations by Health Canada and of the minimum practice standards of the OMVQ (which encourages the use of approved drugs), since it is not approved in Canada.
If climazolam were approved in Canada (it is approved in Europe for dogs and cats), it could replace diazepam or midazolam in combination with ketamine or other induction agents.

Definition

Climazolam is an imidazobenzodiazepine derivative used in veterinary medicine as an anesthetic.

Overdosage

Dose (mg/kg): 0.5–2.0 IM, IV
Comments: In combination with an opioid or anaesthetic agent

Climazolam synthesis

59467-76-4
59467-77-5
Synthesis of Climazolam from 3H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-chlorophenyl)-3a,4-dihydro-1-methyl-

Climazolam Preparation Products And Raw materials

Raw materials

3H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-chlorophenyl)-3a,4-dihydro-1-methyl-

Preparation Products

Climazolam Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
Xiamen Wonderful Bio Technology Co., Ltd. 		+8613043004613 Sara@xmwonderfulbio.com China 305 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Jiangsu shring Biopharma Co., Ltd. 		+8613372282299 sales@shringchem.com China 3545 58
Hebei Ningnan Trade Co. LTD 		+86-18034019111 admin@hbningnan.com China 278 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 50002 58
Wuhan Han Sheng New Material Technology Co.，Ltd 		+8617798174412 admin01@hsnm.com.cn China 2118 58
Supplier Advantage
Xiamen Wonderful Bio Technology Co., Ltd. 		58
Anhui Ruihan Technology Co., Ltd 		58
Jiangsu shring Biopharma Co., Ltd. 		58
Hebei Ningnan Trade Co. LTD 		58
GIHI CHEMICALS CO.,LIMITED 		58
Wuhan Han Sheng New Material Technology Co.，Ltd 		58

View Lastest Price from Climazolam manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
8-chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine pictures 2024-01-18 8-chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
59467-77-5
 US $120.00 / KG 1KG 99% large quantity Xiamen Wonderful Bio Technology Co., Ltd.
Climazolam pictures 2023-09-11 Climazolam
59467-77-5
 US $30.00 / kg 1kg 99% 1000t/year Anhui Ruihan Technology Co., Ltd
Climazolam pictures 2022-11-02 Climazolam
59467-77-5
 US $100.00 / KG 0.10000000149011612KG 99.99% 20MT Hebei Ningnan Trade Co. LTD
  • Climazolam pictures
  • Climazolam
    59467-77-5
  • US $30.00 / kg
  • 99%
  • Anhui Ruihan Technology Co., Ltd
  • Climazolam pictures
  • Climazolam
    59467-77-5
  • US $100.00 / KG
  • 99.99%
  • Hebei Ningnan Trade Co. LTD

59467-77-5(Climazolam)Related Search:

(1H-IMIDAZOL-4-YL)METHANAMINE Climazolam 1-(4-CHLOROPHENYL)IMIDAZOLE 1-O-TOLYL-1H-IMIDAZOLE
Climazolam 8-Chloro-6-(2-chlorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine Ro-21-3982 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-chlorophenyl)-1-methyl- 59467-77-5