Tylophorine
- CAS No.
- 482-20-2
- Chemical Name:
- Tylophorine
- Synonyms
- tylophorine;NSTP 0G01;NSC 76387;NSC 717335;Tylophorin;(+)-(S)-Tylophorine;Tylophorine ( (+)-(S)-Tylophorine;6,7,10,11-Tetramethoxy-2,3-trimethylene-1,2,3,4-tetrahydrodibenzo[f,h]isoquinoline;9,11,12,13,13a,14-Hexahydro-2,3,6,7-tetramethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinoline;(S)-9,11,12,13,13a,14-Hexahydro-2,3,6,7-tetramethoxydibenzo(f,h)pyrrol o(1,2-b)isoquinoline
- CBNumber:
- CB91237105
- Molecular Formula:
- C24H27NO4
- Molecular Weight:
- 393.48
- MDL Number:
- MFCD28899089
- MOL File:
- 482-20-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 125-130 °C (decomp) |
|---|---|
| Boiling point | 559.9±45.0 °C(Predicted) |
| alpha | D23 +15° (c = 0.7 in chloroform); D21 +73° (c = 0.7 in chloroform) |
| Density | 1.26±0.1 g/cm3(Predicted) |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 7.63±0.20(Predicted) |
| color | Pale Yellow to Yellow |
| FDA UNII | O41630Y8V3 |
Tylophorine price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-T898200-1MG | (+)-(S)-Tylophorine | 482-20-2 | 1mg | $270 | 2026-06-03 | Buy |
| TRC | TRC-T898200-10MG | (+)-(S)-Tylophorine | 482-20-2 | 10mg | $2058 | 2026-06-03 | Buy |
| ChemScene | CS-0083718 | Tylophorine | 482-20-2 | 1mg | $612 | 2026-06-04 | Buy |
| ChemScene | CS-0083718 | Tylophorine | 482-20-2 | 10mg | $4669 | 2026-06-04 | Buy |
| aablocks | AA00DDA6 | (+)-(S)-Tylophorine | 482-20-2 | 1mg | $336 | 2026-05-28 | Buy |
Tylophorine Chemical Properties, Uses, Production
Description
Tylophorine is an alkaloid first isolated in 1935 from plants of the genus Tylophora. Studies have demonstrated that this class of alkaloids, characterized by a phenanthroindolizidine skeleton, exhibits potent antitumor, anti-inflammatory, and antiviral activities. A representative tylophorine analogue, DCB-3503 (NSC-716802, 1), displayed an average GI₅₀ value of approximately 10⁻⁸ M against 59 human tumor cell lines in the National Cancer Institute (NCI) anticancer drug screening panel and also inhibited the proliferation of multidrug-resistant tumor cells. Tylocrebrine, another representative member of this class, advanced to Phase I clinical trials as a potential antitumor agent but was subsequently withdrawn because of severe neurotoxicity. Although extensive studies have investigated the antitumor mechanisms of tylophorine alkaloids, their direct molecular targets remain unclear.[1]
Uses
(+)-(S)-Tylophorine is a a major alkaloid of Tylophora indica. (+)-(S)-Tylophorine is an immunosuppressant and inflammation inhibitor. (+)-(S)-Tylophorine showed antiproliferative activity and induction of apoptosis in tumor cells.
Definition
ChEBI: Tylophorine is an organonitrogen heterocyclic compound and an organic heteropentacyclic compound.
References
[1] Liu, Yuxiu, et al. “6-OH-Phenanthroquinolizidine Alkaloid and Its Derivatives Exert Potent Anticancer Activity by Delaying S Phase Progression.” Journal of Medicinal Chemistry, 60 7, 2017, pp. 2764–79, https://doi.org/10.1021/acs.jmedchem.6b01502.
[2] Zeng, W., and S. Chemler. “Synthesis of (S)-(+)-Tylophorine.” Synfacts, 22 1, 2009, pp. 0004–0004, https://doi.org/10.1055/s-0028-1087241.
[3] Masal, Dattatraya P., and D. Srinivasa Reddy. “Gram-Scale Synthesis of (±)-Tylophorine.” Synlett, 55 1, 2024, https://doi.org/10.1055/a-2351-4828.
[4] Sotto, Antonella Di, et al. “Benzoindolizidine Alkaloids Tylophorine and Lycorine and Their Analogues with Antiviral, Anti-Inflammatory, and Anticancer Properties: Promises and Challenges.” Biomedicines, 11 10, 2023, https://doi.org/10.3390/biomedicines11102619.
Tylophorine Preparation Products And Raw materials
Raw materials
Preparation Products
Tylophorine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 18080489829@163.com | China | 8560 | 60 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684; | sales@rrkchem.com | China | 57330 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Hubei Xinkang Pharmaceutical Chemical Co., Ltd | 027-027-59308705 18871579363 | 1248680011@qq.com | China | 9259 | 58 |
| Hubei Tuobang Chemical Co., Ltd. | 027-59106185 13986192185 | 1466039@qq.com | China | 9545 | 58 |
| Hubei Chenghai Chemical Co., Ltd | 027-59220433 18327245847 | 1400838877@qq.com | China | 9507 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29873 | 58 |
| Nanjing Yiming Pharmaceutical Technology Co., Ltd. | 19850700912; 19850700912 | 13851286085@163.com | China | 1000 | 58 |
