phyllomedusin
- CAS No.
- 26145-48-2
- Chemical Name:
- phyllomedusin
- Synonyms
- L-Methioninamide, 5-oxo-L-prolyl-L-asparaginyl-L-prolyl-L-asparaginyl-L-arginyl-L-phenylalanyl-L-isoleucylglycyl-L-leucyl-
- CBNumber:
- CB91335908
- Molecular Formula:
- C52H82N16O13S
- Molecular Weight:
- 1171.37
- MDL Number:
- MFCD00080016
- MOL File:
- 26145-48-2.mol
| Product description | Number | Pack Size | Price |
| PHYLLOMEDUSIN 95.00% | PEP0002855 | 1MG | $641.3 |
| PHYLLOMEDUSIN 95.00% | PEP0002855 | 2MG | $674.98 |
| PHYLLOMEDUSIN 95.00% | PEP0002855 | 5MG | $872.2 |
phyllomedusin price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | PEP0002855 | PHYLLOMEDUSIN 95.00% | 26145-48-2 | 1MG | $641.3 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0002855 | PHYLLOMEDUSIN 95.00% | 26145-48-2 | 2MG | $674.98 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0002855 | PHYLLOMEDUSIN 95.00% | 26145-48-2 | 5MG | $872.2 | 2021-12-16 | Buy |
phyllomedusin Chemical Properties,Uses,Production
Uses
Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus[1][2][3].
in vivo
Phyllomedusin (30-300 μg/kg, i.p.) delays gastric emptying in conscious rats[2].
Phyllomedusin (0.1 and 5 μg/kg, i.v.) has stimulant activity on the stomach of the anaesthetized rat[3].
| Animal Model: | Conscious rats[2]. |
| Dosage: | 30, 100, 300 μg/kg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Caused 75% delay in gastric emptying in conscious rats. |
IC 50
NK1
References
[1] Ganjiwale AD, et al. Three-dimensional structure of Phyllomedusin, a NK1 receptor agonist bound to dodecylphosphocholine micelles. J Struct Biol. 2009 Aug;167(2):176-84. DOI:10.1016/j.jsb.2009.04.008
[2] Bertaccini G, et al. Effect of substance P and its natural analogues on gastric emptying of the conscious rat. Br J Pharmacol. 1981 Feb;72(2):221-3. DOI:10.1111/j.1476-5381.1981.tb09116.x
[3] Bertaccini G, et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6. DOI:10.1007/BF00508624
[4] Sacco MA, et al. Kambo: Natural drug or potential toxic agent? A literature review of acute poisoning cases. Toxicol Rep. 2022 Apr 15;9:905-913. DOI:10.1016/j.toxrep.2022.04.005
phyllomedusin Preparation Products And Raw materials
Raw materials
Preparation Products
phyllomedusin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaoxing Junyu Biotechnology Co., LTD | 0571-0571-88211921 19105816207 | sales4@gotopbio.com | China | 5144 | 58 |
| Enzo Biochem Inc | Enzo Biochem Inc. 13797054060 | Enzoname@qq.com | China | 6174 | 58 |
| Santa Cruz Biotechnology Inc | 021-60936350 | scbt@scbt.com | China | 6594 | 58 |
| Cohesion Biosciences | 0512-67583809 | sales@cohesionbio.com | China | 6282 | 58 |
| Fuan Bio | 18178976185 | 3855357086@qq.com | China | 2061 | 58 |
| Qingdao Everest Technology & Trade Co., Ltd. | 13792478491 | CHINA | 161 | 58 |
| Supplier | Advantage |
|---|---|
| Shaoxing Junyu Biotechnology Co., LTD | 58 |
| Enzo Biochem Inc | 58 |
| Santa Cruz Biotechnology Inc | 58 |
| Cohesion Biosciences | 58 |
| Fuan Bio | 58 |
| Qingdao Everest Technology & Trade Co., Ltd. | 58 |
