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CL-421

CL-421 structure

CAS No.: 1867-65-8

Chemical Name:: CL-421

Synonyms: GK 0;CL-421;Thienylcyclidine;Thienylphencyclidine;1-[1-(2-Thienyl)cyclohexyl]piperidine Hydrochloride;1-(1-thiophen-2-ylcyclohexyl)piperidine:hydrochloride

CBNumber:: CB92138971

Molecular Formula:: C15H24ClNS

Molecular Weight:: 285.87576

MDL Number:

MOL File:: 1867-65-8.mol

Last updated:2023-06-08 09:02:18

CL-421 Properties

Melting point	233-236 °C
solubility	DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml; Ethanol: 2 mg/ml; Methanol: 1 mg/ml
form	A crystalline solid
FDA UNII	425WW340S2

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS05

Signal word

Danger

Hazard statements

H318-H335-H315

Precautionary statements

P280-P305+P351+P338-P310-P264-P280-P302+P352-P321-P332+P313-P362

NFPA 704

	0
3		0

CL-421 Chemical Properties,Uses,Production

Description

Tenocyclidine (TCP), known more formally as N-[1-(2-thienyl)cyclohexyl] piperidine, is an analog of phencyclidine (PCP) in which the phenyl substituent is replaced with a thiophene group. TCP is a potent antagonist of the NMDA receptor-gated ion channel (K_d = 9 nM). TCP blocks NMDA-activated excitatory postsynaptic potential in brain more potently than PCP. PCP and many analogs, including TCP, block the uptake and enhance the release of dopamine both in vitro and in vivo. TCP is regulated as a Schedule I compound in the United States. This product is intended for forensic and research applications.

Uses

An analog of the hallucinogen Phencyclidine (P295500).

CL-421 Preparation Products And Raw materials

Raw materials

Preparation Products

CL-421 1-[1-(2-Thienyl)cyclohexyl]piperidine Hydrochloride GK 0 Thienylcyclidine Thienylphencyclidine 1-(1-thiophen-2-ylcyclohexyl)piperidine:hydrochloride 1867-65-8 C15H24ClNS Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds