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(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate structure

CAS No.: 1160294-26-7

Chemical Name:: (Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

Synonyms: BIBF1120 7.4G;Vargatef Methyl ester;methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate;(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate;2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid methyl ester;1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester;1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-4-[methyl[2-(4- methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester

CBNumber:: CB92469909

Molecular Formula:: C31H33N5O4

Molecular Weight:: 539.62

MDL Number:

MOL File:: 1160294-26-7.mol

MSDS File:: SDS

Last updated:2023-07-12 16:52:01

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(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Properties

Boiling point	742.2±60.0 °C(Predicted)
Density	1.284
pka	11.06±0.20(Predicted)

(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Chemical Properties,Uses,Production

Definition

ChEBI: Nintedanib is a member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, a vascular endothelial growth factor receptor antagonist, a fibroblast growth factor receptor antagonist and an angiogenesis inhibitor. It is an aromatic ester, a methyl ester, a member of oxindoles, an enamine, an aromatic amine, an aromatic amide and a N-alkylpiperazine. It is a conjugate base of a nintedanib(1+).

(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate synthesis

Synthesis of (Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate from N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide and 2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester

(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Preparation Products And Raw materials

Raw materials

N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 2,3-Dihydro-3-(MethoxyphenylMethylene)-2-oxo-1H-indole-6-carboxylic acid Methyl ester Methyl 2-oxoindole-6-carboxylate 1-Acetyl-3-(ethoxyphenylmethylene)-2,3-dihydro-2-oxo-1H-indole-6-carboxylic acid methyl ester

2-CHLORO-N-METHYL-N-(4-NITROPHENYL)ACETAMIDE 1-Methylpiperazine

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Preparation Products

(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate Suppliers

Global( 20)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
China Kouting Group Limited	+86 (21) 5811-6473 5811-6475	sales@koutingchina.com	China	496	60
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2384	58
Zhengzhou Acme Chemical Co., Ltd.	0371-0371-55629727 13323845623	2885676761@qq.com	China	9859	58
Heta Pharm & Chem CO.,Ltd.	+86-571-88298691 89905385	sales@hetapharm.com	China	72	60
Wuxi KaideRui Pharmaceutical Technology Co., Ltd	19906241957	1557216087@qq.com	China	1947	55
Amatek Scientific Co. Ltd.	0512-56316828	info@amateksci.com	China	28822	58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.	027-87466105 15377573527	2678564200@qq.com	China	17997	58

Supplier	Advantage
Hefei TNJ Chemical Industry Co.,Ltd.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Amadis Chemical Company Limited	58
China Kouting Group Limited	60
LETOPHARM LIMITED	58
Zhengzhou Acme Chemical Co., Ltd.	58
Heta Pharm & Chem CO.,Ltd.	60
Wuxi KaideRui Pharmaceutical Technology Co., Ltd	55
Amatek Scientific Co. Ltd.	58
Wuhan FengyaoTonghui Chemical Products Co., Ltd.	58

(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate BIBF1120 7.4G 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-4-[methyl[2-(4- methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester 2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid methyl ester Vargatef Methyl ester methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester 1160294-26-7