2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
- CAS No.
- 383432-38-0
- Chemical Name:
- 2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide
- Synonyms
- 714;CP724;CP-724;CP 724;CS-2306;CP-724714(b);CP 724714 NEW;CP-724714 (E-Double bond);CP 724714;CP724714;CP-724714 (E-DOUBLE BOND);CP-724;714;CP724;714;CP 724714;CP 724;714;CP724714;CP-724714
- CBNumber:
- CB92484874
- Molecular Formula:
- C27H27N5O3
- Molecular Weight:
- 469.54
- MDL Number:
- MFCD15144738
- MOL File:
- 383432-38-0.mol
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide Properties
Boiling point | 687.3±55.0 °C(Predicted) |
---|---|
Density | 1.251 |
storage temp. | Store at -20°C |
solubility | DMF: 3 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml; Ethanol: 2 mg/ml |
form | A crystalline solid |
pka | 13.95±0.46(Predicted) |
color | Light yellow to yellow |
FDA UNII | I05QZ0S4V3 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P280-P305+P351+P338 |
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide price More Price(23)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PZ0335 | CP724714 ≥98% (HPLC) | 383432-38-0 | 5MG | $108 | 2024-03-01 | Buy |
Sigma-Aldrich | PZ0335 | CP724714 ≥98% (HPLC) | 383432-38-0 | 25MG | $435 | 2024-03-01 | Buy |
Cayman Chemical | 19172 | CP 724,714 ≥95% | 383432-38-0 | 1mg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 19172 | CP 724,714 ≥95% | 383432-38-0 | 5mg | $142 | 2024-03-01 | Buy |
Cayman Chemical | 19172 | CP 724,714 ≥95% | 383432-38-0 | 10mg | $266 | 2024-03-01 | Buy |
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide Chemical Properties,Uses,Production
Description
CP 724,714 is a selective inhibitor of HER2/ErbB2 with an IC50 value of 10 nM. It demonstrates greater than 640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, and c-Met. CP 724,714 has been shown to inhibit the proliferation of ErbB2-amplified cells, including BT474 and SK-BR-3 with IC50 values of 0.25 and 0.95 μM, respectively. It also demonstrates antitumor activity in various human tumor xenograft models. However, CP 724,714 was discontinued from clinical development due to hepatotoxicity caused by its ability to inhibit hepatic efflux transporters at low micromolar concentrations.
Uses
CP 724714 is a HER-2 tyrosine kinase inhibitor used in tumor treatments for HER2 positive solid tumors.
Definition
ChEBI: CP-724714 is a 2-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamide in which the double bond adopts a trans-configuration. It is a potent inhibitor of HER2/ErbB2 (IC50 = 10 nM) and exhibits anti-cancer activity. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an antineoplastic agent, an apoptosis inducer and a hepatotoxic agent.
2-Methoxy-N-[(2E)-3-[4-[[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]phenyl]amino]-6-quinazolinyl]-2-propen-1-yl]acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6008 | 61 |
Shanghai Paulshine Chemical Co., Ltd. | +86-021-37788663 | China | 186 | 64 | |
China Langchem Inc. | 0086-21-58956006 | China | 7815 | 57 |