Gilenia
- CAS No.
- 162359-55-9
- Chemical Name:
- Gilenia
- Synonyms
- Gilenia;Fingolise;fingolimo;fenogliMod;Fingolimod;FingoliMod-D4;FingoliMod Base;Gilenia USP/EP/BP;Gilenya(Fingolise);Fingolimod(FTY720)
- CBNumber:
- CB92498299
- Molecular Formula:
- C19H33NO2
- Molecular Weight:
- 307.47
- MDL Number:
- MFCD14705150
- MOL File:
- 162359-55-9.mol
| Melting point | 103-105° |
|---|---|
| Boiling point | 479.5±45.0 °C(Predicted) |
| Density | 1.016 |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Very Slightly, Heated), DMSO (Slightly, Heated), Methanol (Slightly, |
| pka | 12.20±0.20(Predicted) |
| form | Solid |
| color | Off-White |
| FDA UNII | 3QN8BYN5QF |
| ATC code | L04AA27 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H402-H412 | |||||||||
| Precautionary statements | P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
Gilenia price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11975 | Fingolimod ≥98% | 162359-55-9 | 5mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 11975 | Fingolimod ≥98% | 162359-55-9 | 10mg | $105 | 2024-03-01 | Buy |
| Cayman Chemical | 11975 | Fingolimod ≥98% | 162359-55-9 | 25mg | $241 | 2024-03-01 | Buy |
| Cayman Chemical | 11975 | Fingolimod ≥98% | 162359-55-9 | 50mg | $429 | 2024-03-01 | Buy |
| TRC | F342045 | Fingolimod | 162359-55-9 | 50mg | $310 | 2021-12-16 | Buy |
Gilenia Chemical Properties,Uses,Production
Chemical Properties
white solid
Uses
Prophylaxis of organ rejection in patients receiving allogenic renal transplants (sphingosine-1-phosphate receptor).
Uses
Fingolimod is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs.
Definition
ChEBI: An aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimo is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate.
Clinical Use
Sphingosine 1-phosphate receptor modulator:Treatment of highly active relapsing-remitting multiple sclerosis
Drug interactions
Potentially hazardous interactions with other drugs Anti-arrhythmics: possible increased risk of bradycardia with amiodarone, disopyramide and dronedarone. Antifungals: concentration increased by ketoconazole. Beta-blockers: possibly increased risk of bradycardia. Calcium channel blockers: possible increased risk of bradycardia with diltiazem and verapamil.
Metabolism
Transformed by reversible stereoselective phosphorylation to the pharmacologically active (S)-enantiomer of fingolimod phosphate. It is eliminated by oxidative biotransformation mainly via the cytochrome P450 4F2 isoenzyme and subsequent fatty acid-like degradation to inactive metabolites, and by formation of pharmacologically inactive non-polar ceramide analogues of fingolimod. The main enzyme involved in the metabolism of fingolimod is partially identified and may be either CYP4F2 or CYP3A4. 81% excreted as inactive metabolites in the urine and <2.5% in the faeces as metabolites and unchanged drug.
Gilenia Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
| Casorganics US Corp | +17326109938 | sales@casorganics.com | CHINA | 174 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 |
View Lastest Price from Gilenia manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-27 | Gilenia
162359-55-9
|
US $10.00 / KG | 1KG | 99% | 500MT/month | XINGTAI XINGJIU NEW MATERIAL TECHNOLOGY CO., LTD | |
 |
2021-07-13 | Gilenia
162359-55-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | Gilenia
162359-55-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
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