2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione
![2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Structure](CAS/GIF/332382-54-4.gif)
- CAS No.
- 332382-54-4
- Chemical Name:
- 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione
- Synonyms
- ML-SA1;STK095286;EU-0040486;MLS000526272;BAS 01520422;SMR000116746;Oprea1_593964;Oprea1_383174;CBMicro_009667;ChemDiv1_023217
- CBNumber:
- CB92555129
- Molecular Formula:
- C22H22N2O3
- Molecular Weight:
- 362.42
- MDL Number:
- MFCD01956583
- MOL File:
- 332382-54-4.mol
- MSDS File:
- SDS
2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Properties
| Boiling point | 546.7±43.0 °C(Predicted) |
|---|---|
| Density | 1.226±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | 1.16±0.60(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H410 | |||||||||
| Precautionary statements | P273-P301+P310-P501 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-50/53 | |||||||||
| Safety Statements | 60-61 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| NFPA 704 |
|
2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0627 | ML-SA1 ≥95% (HPLC) | 332382-54-4 | 25mg | $156 | 2024-03-01 | Buy |
| Cayman Chemical | 29958 | ML-SA1 | 332382-54-4 | 10mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 29958 | ML-SA1 | 332382-54-4 | 250mg | $586 | 2024-03-01 | Buy |
| Cayman Chemical | 29958 | ML-SA1 | 332382-54-4 | 50mg | $183 | 2024-03-01 | Buy |
| Cayman Chemical | 29958 | ML-SA1 | 332382-54-4 | 100mg | $321 | 2024-03-01 | Buy |
2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Chemical Properties,Uses,Production
Description
ML-SA1 (332382-54-4) is a?TRPML 1,2 and 3 channel activator.1?Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2?ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2?(1 μM).2?Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+?release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3?Reduces intralysosomal Ca2+?level rescuing abnormal lysosomal storage in FIG4-deficient cells.4
Uses
ML-SA1 has been used as a transient receptor potential cation channel mucolipin 1 (TRPML1/ML1) agonist.
Biochem/physiol Actions
ML-SA1 is a potent and selective cell permeable agonist of lysosomal mucolipin transient receptor potential channels (TRPML) 1, 2, 3 that significantly increases [Ca2+]cyt in HEK293 cells stably- or transiently-expressing mutant TRPML1 channels ML1-4A.
storage
Store at +4°C
References
1) Grimm?et al. (2010),?Small molecule activators of TRPML3; Mol. Chem. Biol.,?17?135 2) Shen?et al. (2012),?Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release; Nature Commun.,?3?731 3) Weiss?et al. (2012),?Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases; Commun. Integer. Biol.,?5?111 4) Zou?et al. (2015),?Reactivation of lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells;J. Neurosci., 35?6801
2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl)ethyl]-1H-isoindole-1,3(2H)-dione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 18017383231 18017383231 | lyh_antaeus@163.com | China | 9352 | 55 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |