Dofequidar fuMarate
- CAS No.
- 153653-30-6
- Chemical Name:
- Dofequidar fuMarate
- Synonyms
- Dofequidar (2E)-2-butenedioate (1:1);Dofequidar,Inhibitor,MS209,CD243,ABCB1,MS 209,Dofequidar fumarate,Multidrug resistance protein 1,Cluster of differentiation 243,P-gp,P-glycoprotein,MDR1,inhibit,Pgp
- CBNumber:
- CB92627774
- Molecular Formula:
- C34H35N3O7
- Molecular Weight:
- 597.6576
- MDL Number:
- MFCD00925095
- MOL File:
- 153653-30-6.mol
Dofequidar fuMarate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-2041 | Dofequidar fumarate 99.99% | 153653-30-6 | 10mg | $156 | 2021-12-16 | Buy |
| ChemScene | CS-2041 | Dofequidar fumarate 99.99% | 153653-30-6 | 5mg | $96 | 2021-12-16 | Buy |
| ChemScene | CS-2041 | Dofequidar fumarate 99.99% | 153653-30-6 | 50mg | $600 | 2021-12-16 | Buy |
| ApexBio Technology | B1167 | Dofequidar fumarate | 153653-30-6 | 50mg | $805 | 2021-12-16 | Buy |
| ChemScene | CS-2041 | Dofequidar fumarate 99.99% | 153653-30-6 | 100mg | $1020 | 2021-12-16 | Buy |
Dofequidar fuMarate Chemical Properties,Uses,Production
Biological Activity
dofequidar fumarate is a multidrug-resistant (mdr) - reversal agent [1].dofequidar fumarate is a quinoline derivative and has highly potent reversing effect on multidrug-resistant tumor cells. it prevents the transport of antitumor drugs through interacting with the drug-efflux pump p-glycoprotein directly and thereby reverses mdr. in vincristine (vcr)-resistant p388/vcr cells and adriamycin (adm)- resistant p388/adm cells, dofequidar fumarate at 1μm and 3μm can completely reverse the drug resistance. it also shows significant effects on the mdr k562 cells. furthermore, in mice model bearing hct-15 xenografts, combination therapy of dofequidar fumarate and docetaxel induces remarkable tumor growth inhibition. dofequidar fumarate also shows significant reversing effect in mcf-7/adm-bearing mice [1, 2].
References
[1] sato w, fukazawa n, nakanishi o, et al. reversal of multidrug resistance by a novel quinoline derivative, ms-209. cancer chemotherapy and pharmacology, 1995, 35(4): 271-277.
[2] naito m, matsuba y, sato s, et al. ms-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. clinical cancer research, 2002, 8(2): 582-588.
Dofequidar fuMarate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4979 | 55 |