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SB-674042

SB-674042 Structure
SB-674042 structure
CAS No.
483313-22-0
Chemical Name:
SB-674042
Synonyms
SB-674042;SB 674042; SB674042;SB-674042, CID10204153;SB 674042 >=98% (HPLC);[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone;Methanone, [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]-;(S)-1-[5-[2-Fluorophenyl]-2-methylthiazol-4-yl]-1-[2-[[5-phenyl-[1,3,4]oxadiazol-2-yl]methyl]pyrrolidin-1-yl]methanone;[5-(2-FLUOROPHENYL)-2-METHYL-1,3-THIAZOL-4-YL]-[(2S)-2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHYL]PYRROLIDIN-1-YL]METHANONE;(2S)- 1-[[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-pyrrolidine (9CI)
CBNumber:
CB92628382
Molecular Formula:
C24H21FN4O2S
Molecular Weight:
448.51
MDL Number:
MFCD18251550
MOL File:
483313-22-0.mol
MSDS File:
SDS
Last updated:2025-12-07 19:09:50
Product description Number Pack Size Price
SB 674042 ≥98% (HPLC) SML0912 5mg $131
SB 674042 ≥98% (HPLC) SML0912 25mg $523
SB 674042 ≥98% 21270 1mg $34
SB 674042 ≥98% 21270 5mg $117
SB 674042 ≥98% 21270 10mg $216
Request For Quotation

SB-674042 Properties

Boiling point 655.9±65.0 °C(Predicted)
Density 1.326±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble10mg/mL, clear
pka 0.74±0.10(Predicted)
form powder
color white to beige
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

SB-674042 price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0912 SB 674042 ≥98% (HPLC) 483313-22-0 5mg $131 2025-07-31 Buy
Sigma-Aldrich SML0912 SB 674042 ≥98% (HPLC) 483313-22-0 25mg $523 2025-07-31 Buy
Cayman Chemical 21270 SB 674042 ≥98% 483313-22-0 1mg $34 2024-03-01 Buy
Cayman Chemical 21270 SB 674042 ≥98% 483313-22-0 5mg $117 2024-03-01 Buy
Cayman Chemical 21270 SB 674042 ≥98% 483313-22-0 10mg $216 2024-03-01 Buy
Product number Packaging Price Buy
SML0912 5mg $131 Buy
SML0912 25mg $523 Buy
21270 1mg $34 Buy
21270 5mg $117 Buy
21270 10mg $216 Buy

SB-674042 Chemical Properties,Uses,Production

Uses

SB 674042 is a novel nonpeptide antagonist to OX-1.

Biochem/physiol Actions

SB-674042 is potent and selective OX1R antagonist. SB-674042 binds with high affinity to OX1R and mediates intracellular calcium flux in OX1R-expressing cells.

in vivo

SB-674042 (0.3 nM/0.3 μL; icv; single dose) reduces contextual and cues fear freezing responses in Stay animals in Stress Alternatives Model (SMA) in mice[4].

Animal Model:Stress-induced mice model (male C57BL/6NHsd mice, 22-26 g)[4]
Dosage:0.3 nM/0.3 μL
Administration:Intracerebroventricular injection; subjected mice to 4 days of social aggression (days 1-4)
Result:Resulted 39.4% Escape and 60.6% Stay phenotypes among mice.

IC 50

OX1 Receptor: 3.76 nM (IC50); OX2 Receptor: 531 nM (IC50); OX1 Receptor: 1.1 nM (Ki); OX2 Receptor: 129 nM (Ki)

storage

Store at +4°C

SB-674042 Preparation Products And Raw materials

Raw materials

Preparation Products

SB-674042 Suppliers

Global( 74)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998 757984502@qq.com China 892 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51395 80
SPIRO PHARMA eric_feng1954@126.com China 9248 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		58
Haoyuan Chemexpress Co., Ltd. 61
LETOPHARM LIMITED 58
Sigma-Aldrich 80
SPIRO PHARMA 55

View Lastest Price from SB-674042 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SB-674042 pictures 2025-12-05 SB-674042
483313-22-0
 US $45.00 / mg 99.90% 10g TargetMol Chemicals Inc.
  • SB-674042 pictures
  • SB-674042
    483313-22-0
  • US $45.00 / mg
  • 99.90%
  • TargetMol Chemicals Inc.

483313-22-0(SB-674042)Related Search:

Sulfanilamide Lignosulfonic acid Angeli’s Salt TRIS(PENTAFLUOROPHENYL)PHOSPHINE 2-FLUOROPHENYL CYCLOPENTYL KETONE
SB-674042 (S)-1-[5-[2-Fluorophenyl]-2-methylthiazol-4-yl]-1-[2-[[5-phenyl-[1,3,4]oxadiazol-2-yl]methyl]pyrrolidin-1-yl]methanone (2S)- 1-[[5-(2-Fluorophenyl)-2-methyl-4-thiazolyl]carbonyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-pyrrolidine (9CI) [5-(2-Fluorophenyl)-2-methyl-4-thiazolyl][2(S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl-1-pyrrolidinyl]methanone SB 674042; SB674042 [5-(2-FLUOROPHENYL)-2-METHYL-1,3-THIAZOL-4-YL]-[(2S)-2-[(5-PHENYL-1,3,4-OXADIAZOL-2-YL)METHYL]PYRROLIDIN-1-YL]METHANONE SB-674042, CID10204153 Methanone, [5-(2-fluorophenyl)-2-methyl-4-thiazolyl][(2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]-1-pyrrolidinyl]- SB 674042 >=98% (HPLC) 483313-22-0 C24H21N4O2FS