(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride
- CAS No.
- 1431697-78-7
- Chemical Name:
- (S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride
- Synonyms
- CAL-130 HCl;CAL-130 (Hydrochloride);CAL130 Hydrochloride,CAL 130 Hydrochloride;(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride;2-[(1S)-1-[(2-Amino-9H-purin-6-yl)amino]ethyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone hydrochloride (1:1)
- CBNumber:
- CB92666603
- Molecular Formula:
- C23H23ClN8O
- Molecular Weight:
- 462.94
- MDL Number:
- MFCD25372043
- MOL File:
- 1431697-78-7.mol
(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Biosynth Carbosynth | FC64968 | CAL 130 hydrochloride | 1431697-78-7 | 10mg | $175 | 2021-12-16 | Buy |
ChemScene | CS-1300 | CAL-130Hydrochloride 99.88% | 1431697-78-7 | 5mg | $264 | 2021-12-16 | Buy |
ApexBio Technology | A3268 | CAL-130Hydrochloride | 1431697-78-7 | 2mg | $279 | 2021-12-16 | Buy |
ChemScene | CS-1300 | CAL-130Hydrochloride 99.88% | 1431697-78-7 | 10mg | $360 | 2021-12-16 | Buy |
ApexBio Technology | A3268 | CAL-130Hydrochloride | 1431697-78-7 | 5mg | $419 | 2021-12-16 | Buy |
(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Chemical Properties,Uses,Production
Biological Activity
CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor with IC50 of 1.3 and 6.1 nM, respectively.
in vitro
CAL-130 preferentially inhibits the function of both p110γ and p110δ catalytic domains. IC 50 values of CAL-130 are 1.3 and 6.1 nM for p110δ and p110γ, respectively, as compared to 115 and 56 nM for p110α and p110β. CAL-130 does not inhibit additional intracellular signaling pathways (ie, p38 MAPK or insulin receptor tyrosine kinase) that are critical for general cell function and survival.
in vivo
The clinical significance of interfering with the combined activities of PI3Kγ and PI3Kδ is determined by administering CAL-130 to Lck/Pten fl/fl mice with established T cell acute lymphoblastic leukemia (T-ALL). Candidate animals for survival studies are ill appearing, have a white blood cell (WBC) count above 45,000 μL -1 , evidence of blasts on peripheral smear, and a majority of circulation cells (>75%) staining double positive for Thy1.2 and Ki-67. Mice receive an oral dose (10 mg/kg) of CAL-130 every 8 hr for a period of 7 days and are then followed until moribund. Despite the limited duration of therapy, CAL-130 is highly effective in extending the median survival for treated animals to 45 days as compared 7.5 days for the control group.
target
PI3K
(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-2-(1-((2-aMino-9H-purin-6-yl)aMino)ethyl)-5-Methyl-3-(o-tolyl)quinazolin-4(3H)-one hydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |