Kalydeco hydrate
- CAS No.
- 1134822-07-3
- Chemical Name:
- Kalydeco hydrate
- Synonyms
- VX770 hydrate;VX-770 hydrate;VX 770 hydrate;Kalydeco hydrate;Ivacaftor (hydrate);Ivacaftor hydrate (VX-770);Ivacaftor hydrate (VX-770 hydrate;(Z)-N-(2,4-DI-TERT-BUTYL-5-HYDROXYPHENYL)-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBIMIDIC ACID HYDRATE
- CBNumber:
- CB92666643
- Molecular Formula:
- C24H30N2O4
- Molecular Weight:
- 410.51
- MDL Number:
- MOL File:
- 1134822-07-3.mol
Kalydeco hydrate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A3511 | Ivacaftorhydrate | 1134822-07-3 | 10mg | $119 | 2021-12-16 | Buy |
| ApexBio Technology | A3511 | Ivacaftorhydrate | 1134822-07-3 | 50mg | $154 | 2021-12-16 | Buy |
| ApexBio Technology | A3511 | Ivacaftorhydrate | 1134822-07-3 | 100mg | $213 | 2021-12-16 | Buy |
| ApexBio Technology | A3511 | Ivacaftorhydrate | 1134822-07-3 | 5mg | $79 | 2021-12-16 | Buy |
| Crysdot | CD31004506 | Ivacaftorhydrate 98+% | 1134822-07-3 | 10mg | $94 | 2021-12-16 | Buy |
Kalydeco hydrate Chemical Properties,Uses,Production
Description
Ivacaftor hydrate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment.
in vitro
In Vitro:Ivacaftor (10?μM) increases the PC secretion activity by 3-fold for ABCB4-G535D, 13.7-fold for ABCB4-G536R, 6.7-fold for ABCB4-S1076C, 9.4-fold for ABCB4-S1176L, and 5.7-fold for ABCB4-G1178S. Ivacaftor corrects the functional defect of ABCB4 mutants[1]. Ivacaftor (10 μM) significantly increases CFTR activity in W1282X-expressing cells compared to R1162X CFTR cells[2]. Ivacaftor shows no significant activity against 160 targets tested including the GABAA benzodiazepine receptor. Ivacaftor increases the chloride secretion with an EC50 of 0.236 ± 0.200 μM, a 10-fold shift in potency compared to the F508del HBEs[3]. In recombinant cells, VX-770 increases CFTR channel open probability (Po) in both the F508del processing mutation and the G551D gating mutation. VX-770 increases forskolin-stimulated IT in temperature-corrected F508del-FRT cells by appr 6-fold with an EC50 of 25 nM[4].
in vivo
In Vivo:Ivacaftor (1-200 mg/kg, p.o.) exhibits good oral bioavailability in rat[3].
References
References:[1]. Delaunay JL, et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). Hepatology. 2017 Feb;65(2):560-570. [2]. Mutyam V, et al. Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation. J Cyst Fibros. 2017 Jan;16(1):24-29. [3]. Hadida S, et al. Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. J Med Chem. 2014 Dec 11;57(23):9776-95 [4]. Van Goor F, et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18825-30.
Kalydeco hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Kalydeco hydrate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9335 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
View Lastest Price from Kalydeco hydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Ivacaftor hydrate
1134822-07-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Ivacaftor hydrate
1134822-07-3
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
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- Ivacaftor hydrate
1134822-07-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Ivacaftor hydrate
1134822-07-3
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd