RAS-2410 hydrochloride
- CAS No.
- 1187075-34-8
- Chemical Name:
- RAS-2410 hydrochloride
- Synonyms
- Resminostat HCl;RAS2410 hydrochloride;4SC-201 hydrochloride;RAS-2410 hydrochloride;RAS 2410 hydrochloride;ResMinostat (hydrochloride);Resminostat hydrochloride (4SC-201);RAS2410; 4SC-201; RAS 2410; RAS-2410;4SC201;4SC 201;RAS2410 HYDROCHLORIDE; 4SC-201 HYDROCHLORIDE; RAS 2410 HYDROCHLORIDE; RAS-2410 HYDROCHLORIDE;(2E)-3-[1-[[4-[(Dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide hydrochloride (1:1)
- CBNumber:
- CB92666678
- Molecular Formula:
- C16H20ClN3O4S
- Molecular Weight:
- 385.8657
- MDL Number:
- MFCD26142920
- MOL File:
- 1187075-34-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
RAS-2410 hydrochloride price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17553 | Resminostat (hydrochloride) ≥95% | 1187075-34-8 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 17553 | Resminostat (hydrochloride) ≥95% | 1187075-34-8 | 5mg | $190 | 2024-03-01 | Buy |
| Cayman Chemical | 17553 | Resminostat (hydrochloride) ≥95% | 1187075-34-8 | 10mg | $310 | 2024-03-01 | Buy |
| Cayman Chemical | 17553 | Resminostat (hydrochloride) ≥95% | 1187075-34-8 | 50mg | $947 | 2024-03-01 | Buy |
| ApexBio Technology | A3755 | Resminostathydrochloride | 1187075-34-8 | 50mg | $1010 | 2021-12-16 | Buy |
RAS-2410 hydrochloride Chemical Properties,Uses,Production
Description
Resminostat is an orally bioavailable inhibitor of histone deacetylase 1 (HDAC1), HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells. It abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 μM). Resminostat displays synergistic effects when combined with melphalan and the proteasome inhibitors bortezomib and S-2209. It dose-dependently inhibits HDAC activity in vivo.
References
[1] mandl-weber s, meinel fg, jankowsky r, oduncu f, schmidmaier r, baumann p. the novel inhibitor of histone deacetylase resminostat (ras2410) inhibits proliferation and induces apoptosis in multiple myeloma (mm) cells. br j haematol. 2010 may;149(4):518-28.
[2] brunetto at, ang je, lal r, olmos d, molife lr, kristeleit r, parker a, casamayor i, olaleye m, mais a, hauns b, strobel v, hentsch b, de bono js. first-in-human, pharmacokinetic and pharmacodynamic phase i study of resminostat, an oral histone deacetylase inhibitor, in patients with advanced solid tumors. clin cancer res. 2013 oct 1;19(19):5494-504.
RAS-2410 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
RAS-2410 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 | sales@shringchem.com | China | 3545 | 58 |
View Lastest Price from RAS-2410 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-19 | RAS-2410 hydrochloride
1187075-34-8
|
US $0.00 / gram | 1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited |
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- RAS-2410 hydrochloride
1187075-34-8
- US $0.00 / gram
- 99%
- Zhejiang J&C Biological Technology Co.,Limited