ChemicalBook >> CAS DataBase List >>CGP52421
CGP52421
- CAS No.
- 179237-49-1
- Chemical Name:
- CGP52421
- Synonyms
- 3-Hydroxy Midostaurin;CGP52421;Midaustorin metabolite;13C6]-Midostaurin metabolite;Midostaurin metabolite - CGP52421;3-Hydroxy Midostaurin (CGP 52421);Midostaurin Impurity 1 (3-Hydroxy Midostaurin);3-Hydroxy Midostaurin D5Q: What is 3-Hydroxy Midostaurin D5 Q: What is the CAS Number of 3-Hydroxy Midostaurin D5;Benzamide, N-(2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-;N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl benzamide
- CBNumber:
- CB92731037
- Molecular Formula:
- C35H30N4O5
- Molecular Weight:
- 586.65
- MDL Number:
- MOL File:
- 179237-49-1.mol
- MSDS File:
- SDS
Last updated:2023-05-21 10:59:17
| Density | 1.53±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 12.23±0.70(Predicted) |
| FDA UNII | D9B1PJ9MWX |
CGP52421 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H939985 | 3-HydroxyMidostaurin | 179237-49-1 | 2.5mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-0027888 | 3-HydroxyMidostaurin | 179237-49-1 | 5mg | $1150 | 2021-12-16 | Buy |
| ChemScene | CS-0027888 | 3-HydroxyMidostaurin | 179237-49-1 | 10mg | $1950 | 2021-12-16 | Buy |
| ChemScene | CS-0027888 | 3-HydroxyMidostaurin | 179237-49-1 | 50mg | $5500 | 2021-12-16 | Buy |
CGP52421 Chemical Properties,Uses,Production
Uses
3-Hydroxy Midostaurin-d5 is the deuterium labelled 3-Hydroxy Midostaurin (H939985(M)). 3-Hydroxy Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.
Biological Activity
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, potently inhibits FMS-like tyrosine kinase 3 (FLT3) autophosphorylation with IC50s of 132 nM and 9.8 μM in culture medium and plasma, respectively. Compared to PKC412, 3-Hydroxy Midostaurin is less selective but more cytotoxic.
in vitro
CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM.
target
IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)
CGP52421 Preparation Products And Raw materials
Raw materials
Preparation Products
CGP52421 Suppliers
Global( 14)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Artis Biotech Co. Ltd. | 19138486554 18582380095 | sales@artisbio.com | China | 2820 | 58 |
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2251 | 58 |
| Chengdu Peter-like Biotechnology Co., Ltd. | 028-81700200 18108052721 | 2850505130@qq.com | China | 5182 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| Aurisco Pharmaceutical (Tianjin) Inc. | 022-59885855 | liuyujie@aurisco.com | China | 96 | 58 |
| Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 | info@bwtlab.com | China | 9247 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |
179237-49-1(CGP52421)Related Search:
CGP52421
3-Hydroxy Midostaurin (CGP 52421)
Benzamide, N-(2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methyl-
Midostaurin Impurity 1 (3-Hydroxy Midostaurin)
3-Hydroxy Midostaurin D5Q: What is
3-Hydroxy Midostaurin D5 Q: What is the CAS Number of
3-Hydroxy Midostaurin D5
Midostaurin metabolite - CGP52421
3-Hydroxy Midostaurin
N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methyl benzamide
13C6]-Midostaurin metabolite
Midaustorin metabolite
179237-49-1