CREB inhibitor (666-15)
- CAS No.
- 1433286-70-4
- Chemical Name:
- CREB inhibitor (666-15)
- Synonyms
- 666-15;compound3i;CREB 666-15;CREB inhibitor;compound3i(666-15);666-15, 10 mM in DMSO;CREB inhibitor (666-15);breast,666-15,Epigenetic Reader Domain,cancer,CREB,66615,666 15,inhibit,Inhibitor;3-(3-Aminopropoxy)-N-(2-((3-((4-chloro-2-hydroxyphenyl)carbamoyl)naphthalen-2-yl)oxy)ethyl)-2-naphthamide hydrochloride
- CBNumber:
- CB93069852
- Molecular Formula:
- C33H31Cl2N3O5
- Molecular Weight:
- 620.53
- MDL Number:
- MFCD30182343
- MOL File:
- 1433286-70-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
CREB inhibitor (666-15) price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30780 | ≥98% | 1433286-70-4 | 5mg | $169 | 2026-04-30 | Buy |
| Cayman Chemical | 30780 | ≥98% | 1433286-70-4 | 10mg | $268 | 2026-04-30 | Buy |
| Cayman Chemical | 30780 | ≥98% | 1433286-70-4 | 25mg | $502 | 2026-04-30 | Buy |
| Cayman Chemical | 30780 | ≥98% | 1433286-70-4 | 50mg | $835 | 2026-04-30 | Buy |
| ChemScene | CS-6499 | 99.79% | 1433286-70-4 | 1mg | $71 | 2026-06-04 | Buy |
CREB inhibitor (666-15) Chemical Properties, Uses, Production
Uses
3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide Hydrochloride has been identified as an antitumor agent.
Biological Activity
CREB inhibitor (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM. It also inhibits the growth of cancer cells without affecting normal cells.
in vitro
666-15 can effectively inhibit the growth of cancer cells. In MDA-MB-231 and MDA-MB-468 cells, the GI50 values of 666-15 were 73 nM and 46 nM, respectively. 666-15 also had strong activity in A549 and MCF-7 cells, with GI50 of 0.47 μM and 0.31 μM, respectively. 666-15 inhibits the transcriptional activity of CREB in live cells that do not depend on direct CREB or CBP binding reactions.
in vivo
In the in vivo MDA-MB-468 xenograft tumor model, 666-15 completely inhibited tumor growth without obvious toxicity. Intraperitoneal injection of 10 mg/kg of 666-15 in mice was well tolerated.
target
| Target | Value |
| CREB () | 81 nM |
storage
Desiccate at RT
CREB inhibitor (666-15) Preparation Products And Raw materials
Raw materials
Preparation Products
CREB inhibitor (666-15) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai XingMo Biotechnology Co., Ltd. | +86 13524779951; 13524779951 | 2075692521@qq.com | China | 295 | 55 |
| Shanghai Haozhixiang Biotechnology Co., Ltd | 526763801 13301653310 | 526763801@qq.com | China | 8011 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9779 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28149 | 68 |
| Shanghai Jizhi Biochemical Technology Co. Ltd. | 021-4009004166/18616739031 18616739031 | 3007523370@qq.com | China | 40000 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
