INF39
- CAS No.
- 866028-26-4
- Chemical Name:
- INF39
- Synonyms
- INF39;CS-2508;INF39 >=98% (HPLC);INF-39;INF 39;INF39;Ethyl 2-(2-chlorobenzyl)acrylate;Benzenepropanoic acid, 2-chloro-α-methylene-, ethyl ester;inhibit,INF 39,INF39,INF-39,NOD-like Receptor (NLR),Inhibitor
- CBNumber:
- CB93175821
- Molecular Formula:
- C12H13ClO2
- Molecular Weight:
- 224.68
- MDL Number:
- MFCD27930542
- MOL File:
- 866028-26-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
INF39 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2239 | INF39 ≥98% (HPLC) | 866028-26-4 | 5mg | $128 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2239 | INF39 ≥98% (HPLC) | 866028-26-4 | 25mg | $411 | 2024-03-01 | Buy |
| Cayman Chemical | 28476 | INF39 | 866028-26-4 | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 28476 | INF39 | 866028-26-4 | 25mg | $463 | 2024-03-01 | Buy |
| Cayman Chemical | 28476 | INF39 | 866028-26-4 | 10mg | $210 | 2024-03-01 | Buy |
INF39 Chemical Properties,Uses,Production
Uses
INF 39 is a NLRP3 inflammasome inhibitor. Used in the treatment of inflammatory bowel disease.
Biochem/physiol Actions
INF39 is an orally active acrylate derivative and a non-cytotoxic INF4E analog (no toxicity at 100 μM in THP-1 cultures vs. TC50 = 65 μM with INF4E) that acts as an irreversible inhibitor against NLRP3 (NACHT, LRR and PYD domains-containing protein 3) ATPase activity (52% inhibition in 15 min by 100 μM INF39; 105 ng human NLP3 & 250 μM ATP) essential for the NLRP3 inflammasome assembly and activation. INF39 effectively decreases 5 mM (30 min) ATP-induced interleukin-1β (IL-1β) release and pyroptosis of murine bone marrow-derived macrophages in cultures (by 55-58% and 43-65%, respectively, with 1-hr 10 μM INF39 pretreatment of LPS-primed BMDM) and alleviates gut-associated inflammation in a rat model of 2,4-dinitrobenzenesulfonic acid (DNBS)-induced colitis in vivo (12.5-50 mg/kg/day in 0.2 mL olive oil p.o.).
storage
Store at -20°C
INF39 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 357 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
