3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid
![3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Structure](CAS/20180601/GIF/683808-78-8.gif)
- CAS No.
- 683808-78-8
- Chemical Name:
- 3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid
- Synonyms
- Poloppin;Poloppin >=98% (HPLC);1H-Pyrrole-2-propanoic acid, 5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-;3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid
- CBNumber:
- CB93698449
- Molecular Formula:
- C20H15BrF3NO2
- Molecular Weight:
- 438.2378096
- MDL Number:
- MFCD03706653
- MOL File:
- 683808-78-8.mol
| Product description | Number | Pack Size | Price |
| Poloppin ≥98% (HPLC) | SML2186 | 5MG | $67.19 |
| Poloppin ≥98% (HPLC) | SML2186 | 25MG | $360 |
| Poloppin | CS-0087610 | 5mg | $200 |
| Poloppin | CS-0087610 | 10mg | $340 |
| Boiling point | 536.7±50.0 °C(Predicted) |
|---|---|
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 2mg/mL, clear |
| pka | 4.62±0.10(Predicted) |
| form | powder |
| color | white to beige |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2186 | Poloppin ≥98% (HPLC) | 683808-78-8 | 5MG | $67.19 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML2186 | Poloppin ≥98% (HPLC) | 683808-78-8 | 25MG | $360 | 2025-07-31 | Buy |
| ChemScene | CS-0087610 | Poloppin | 683808-78-8 | 5mg | $200 | 2021-12-16 | Buy |
| ChemScene | CS-0087610 | Poloppin | 683808-78-8 | 10mg | $340 | 2021-12-16 | Buy |
3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Chemical Properties,Uses,Production
Description
Poloppin is a modulator of protein-protein interactions of the mitotic polo-like kinases. It acts by targeting mutant KRAS, working synergistically with Crizotinib, an inhibitor of the c-MET receptor, against mutant KRAS-expressing cancer cells.
Uses
Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9?μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5?μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis.?Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors[1].
References
[1] Ana J Narvaez, et al. Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS. Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7. DOI:10.1016/j.chembiol.2017.07.009
3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-{5-(4-bromophenyl)-1-[2-(trifluoromethyl)phenyl]-1H-pyrrol-2-yl}propanoic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9803 | 58 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9118 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29641 | 58 |
| Cayman Chemical Company | 800-364-9897 | sales@caymanchem.com | China | 6838 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
