Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal
- CAS No.
- Chemical Name:
- Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal
- Synonyms
- Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal
- CBNumber:
- CB94669831
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A7732 | Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal clone EA-53, purified from hybridoma cell culture | 100μL | $479 | 2023-06-20 | Buy | |
Sigma-Aldrich | A7732 | Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal clone EA-53, purified from hybridoma cell culture | 200μL | $646 | 2023-06-20 | Buy |
Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal Chemical Properties,Uses,Production
Uses
Mouse Monoclonal Anti-alpha-Actinin (Sarcomeric) antibody has been used for immunocytochemical (1:800) and immunohistochemical (1:100) applications.
General Description
α-Actinin is a 100kDa actin-binding protein that is found in muscle as well as non-muscle cells. In smooth muscles, α-actinin is present in dense bodies and plaques whereas in normal skeletal muscles, it is associated with z-discs that define muscle sarcomeres. The gene encoding α-actinin is mapped to the human chromosome 11q13.2. α-Actinin belongs to the spectrin protein superfamily.
α-Actinin dimerizes in an antiparallel fashion via interaction of the central rod domains. Four isoforms are found in human and mice. α-actinin-1 is ubiquitously expressed and located primarily in focal adhesions, whereas α-actinin-4 is present in certain membrane ruffles and seems to play a role in endocytosis and tumor cell motility.
ACTN1 (α-actinin-1) and ACTN4 (α-actinin-4) encodes non-muscle proteins, while ACTN2 (α-actinin-2) and ACTN3 (α-actinin-3) encodes muscle proteins.
Monoclonal Anti-α-Actinin (Sarcomeric) shows wide reactivity, as it binds to human, bovine, pig, sheep, rabbit, goat, hamster, cat, rat, mouse, dog, chicken, lizard, snake, frog and fish α-actinin.
Biochem/physiol Actions
α-Actinin maintains the structure of cytoskeletal organization and regulates muscle contraction. α-Actinin functions as an actin crosslinker and promotes cell migration. Mutations in the α-actinin gene is observed in heterogeneous hypertrophic cardiomyopathy and in juvenile onset atrial fibrillation.
Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |