Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal

CAS No.
Chemical Name:
Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal
Synonyms
Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal
CBNumber:
CB94669831
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal Properties

storage temp. -20°C
form buffered aqueous solution

Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A7732 Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal clone EA-53, purified from hybridoma cell culture 100μL $479 2023-06-20 Buy
Sigma-Aldrich A7732 Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal clone EA-53, purified from hybridoma cell culture 200μL $646 2023-06-20 Buy
Product number Packaging Price Buy
A7732 100μL $479 Buy
A7732 200μL $646 Buy

Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal Chemical Properties,Uses,Production

Uses

Mouse Monoclonal Anti-alpha-Actinin (Sarcomeric) antibody has been used for immunocytochemical (1:800) and immunohistochemical (1:100) applications.

General Description

α-Actinin is a 100kDa actin-binding protein that is found in muscle as well as non-muscle cells. In smooth muscles, α-actinin is present in dense bodies and plaques whereas in normal skeletal muscles, it is associated with z-discs that define muscle sarcomeres. The gene encoding α-actinin is mapped to the human chromosome 11q13.2. α-Actinin belongs to the spectrin protein superfamily.
α-Actinin dimerizes in an antiparallel fashion via interaction of the central rod domains. Four isoforms are found in human and mice. α-actinin-1 is ubiquitously expressed and located primarily in focal adhesions, whereas α-actinin-4 is present in certain membrane ruffles and seems to play a role in endocytosis and tumor cell motility.
ACTN1 (α-actinin-1) and ACTN4 (α-actinin-4) encodes non-muscle proteins, while ACTN2 (α-actinin-2) and ACTN3 (α-actinin-3) encodes muscle proteins.
Monoclonal Anti-α-Actinin (Sarcomeric) shows wide reactivity, as it binds to human, bovine, pig, sheep, rabbit, goat, hamster, cat, rat, mouse, dog, chicken, lizard, snake, frog and fish α-actinin.

Biochem/physiol Actions

α-Actinin maintains the structure of cytoskeletal organization and regulates muscle contraction. α-Actinin functions as an actin crosslinker and promotes cell migration. Mutations in the α-actinin gene is observed in heterogeneous hypertrophic cardiomyopathy and in juvenile onset atrial fibrillation.

Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal Preparation Products And Raw materials

Raw materials

Preparation Products

Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
Anti-α-Actinin (Sarcomeric) antibody, Mouse monoclonal