InSolution Roscovitine - Calbiochem

CAS No.
Chemical Name:
InSolution Roscovitine - Calbiochem
Synonyms
InSolution Roscovitine - Calbiochem
CBNumber:
CB94817380
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file

InSolution Roscovitine - Calbiochem price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 557364 InSolution Roscovitine - Calbiochem 5mg $251 2023-06-20 Buy
Product number Packaging Price Buy
557364 5mg $251 Buy

InSolution Roscovitine - Calbiochem Chemical Properties,Uses,Production

General Description

A potent and selective inhibitor of cyclin-dependent kinases (Cdks). Exhibits greater inhibitory potency compared to olomoucine (Cat. No. 495620). Inhibits p34 Cdc2/cyclin B (IC50 = 650 nM), p33 Cdk2/cyclin A (IC50 = 700 nM), p33 Cdk2/cyclin E (IC50 = 700 nM), and p33 Cdk2/p35 (IC50 = 200 nM) by competing for the ATP binding domain of these kinases. Exhibits very low sensitivity towards related kinases, such as Erk1 and Erk2 (IC50 = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM and compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle.

Biochem/physiol Actions

Reversible: yes

InSolution Roscovitine - Calbiochem Preparation Products And Raw materials

Raw materials

Preparation Products

InSolution Roscovitine - Calbiochem Suppliers

Global( 2)Suppliers
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Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
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Sigma-Aldrich 80
InSolution Roscovitine - Calbiochem