InSolution Roscovitine - Calbiochem
- CAS No.
- Chemical Name:
- InSolution Roscovitine - Calbiochem
- Synonyms
- InSolution Roscovitine - Calbiochem
- CBNumber:
- CB94817380
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
InSolution Roscovitine - Calbiochem price More Price(1)
InSolution Roscovitine - Calbiochem Chemical Properties,Uses,Production
General Description
A potent and selective inhibitor of cyclin-dependent kinases (Cdks). Exhibits greater inhibitory potency compared to olomoucine (Cat. No. 495620). Inhibits p34 Cdc2/cyclin B (IC50 = 650 nM), p33 Cdk2/cyclin A (IC50 = 700 nM), p33 Cdk2/cyclin E (IC50 = 700 nM), and p33 Cdk2/p35 (IC50 = 200 nM) by competing for the ATP binding domain of these kinases. Exhibits very low sensitivity towards related kinases, such as Erk1 and Erk2 (IC50 = 34 μM and 14 μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100 μM and compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle.
Biochem/physiol Actions
Reversible: yes
InSolution Roscovitine - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
InSolution Roscovitine - Calbiochem Suppliers
Global( 2)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
InSolution Roscovitine - Calbiochem