B-HT 933 DIHYDROCHLORIDE
- CAS No.
- 36067-72-8
- Chemical Name:
- B-HT 933 DIHYDROCHLORIDE
- Synonyms
- b-ht933;Nsc310831;Azepexole hydrochloride;B-HT 933 (hydrochloride);Azepexole dihydrochloride;β2AR/M3-receptor agonist-1;B-HT 933 DIHYDROCHLORIDE SELECTIVE A2 AD RENORE;5-d)azepin-2-amine,5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(dihydrochloride;5,6,7,8-tetrahydro-6-ethyl-4h-oxazolo(4,5-d)azepin-2-aminedihydrochloride;2-amino-6-ethyl-4,5,7,8-tetrahydro-6h-oxazolo(5,4-d)azepinedihydrochloride
- CBNumber:
- CB9496972
- Molecular Formula:
- C9H16ClN3O
- Molecular Weight:
- 217.7
- MDL Number:
- MFCD01529923
- MOL File:
- 36067-72-8.mol
| storage temp. | Desiccate at RT |
|---|---|
| solubility | H2O: >20 mg/mL |
| form | solid |
| color | white to off-white |
| FDA UNII | O596V52O42 |
B-HT 933 DIHYDROCHLORIDE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11941 | B-HT 933 (hydrochloride) ≥95% | 36067-72-8 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 11941 | B-HT 933 (hydrochloride) ≥95% | 36067-72-8 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 11941 | B-HT 933 (hydrochloride) ≥95% | 36067-72-8 | 10mg | $199 | 2024-03-01 | Buy |
| Cayman Chemical | 11941 | B-HT 933 (hydrochloride) ≥95% | 36067-72-8 | 25mg | $456 | 2024-03-01 | Buy |
| TRC | H671813 | B-HT933Dihydrochloride | 36067-72-8 | 25mg | $215 | 2021-12-16 | Buy |
B-HT 933 DIHYDROCHLORIDE Chemical Properties,Uses,Production
Description
B-HT 933 is an agonist of α2-adrenergic receptors (α2-ARs) with an EC50 value of 0.65 μM for contraction of canine sapheneous veins. It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum. B-HT 933 induces sedation and reduces motor activity in mice, an effect that is reversed by the α2-AR antagonist yohimbine . B-HT 933 decreases blood pressure and cardiac output in cats injected with 30 μg/kg intracisternally. It also exhibits antinociceptive effects in mice with ED50 values of 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively.
Uses
B-HT 933 Dihydrochloride is a selective α2-adrenoceptor agonist and has less potent inhibitory effect on the sympathetic vasopressor responses in diabetic rats.
in vitro
b-ht 933, a selective α2-adrenoceptor agonist, contracts human subcutaneous resistance arteries by a mechanism largely dependent on the influx of extracellular ca2+, probably through voltage-operated calcium channels. this action involves a pertussis toxin-sensitive g protein, possibly gq [1].
in vivo
the dose-related effects of the selective α2-adrenoceptor agonist b-ht 933 on the body temperature of untreated and reserpine-treated mice were investigated. in untreated mice b-ht 933 induced a dose-related hypothermia. the highest dose of b-ht 933 elicited a marked hypothermia, whereas the maximal hypothermic effect of clonidine was less pronounced and reached a plateau at a dose of 0.5 mg/kg [2].
IC 50
0.44 μm
storage
Desiccate at RT
References
[1] n. a. parkinson & a.d. hughes. the mechanism of action of 1c2-adrenoceptors in human isolated subcutaneous resistance arteries. british journal of pharmacology (1995) 115, 1463-1468
[2] d. j. bill, i.e. hughes & r.j. stephens. the thermogenic actions of x2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic ac2-adrenoceptor mechanism. br. j. pharmacol. (1989), 96, 133-143
B-HT 933 DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
B-HT 933 DIHYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4191 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |