ChemicalBook >> CAS DataBase List >>2,5-Dioxopyrrolidin-1-yl octanoate

2,5-Dioxopyrrolidin-1-yl octanoate

CAS No.
14464-30-3
Chemical Name:
2,5-Dioxopyrrolidin-1-yl octanoate
Synonyms
Eliglustat Impurity 11;Eliglustat intermediate 6;2,5-dioxopyrrolidin-1-yl octanoate;Octanoic acid-N-succinimidyl ester;1-(Octanoyloxy)-2,5-pyrrolidinedione;Caprylic acid-N-hydroxysuccinimide ester;Octanoic acid N-hydroxy succinimide ester;Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester;N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate
CBNumber:
CB9497580
Molecular Formula:
C12H19NO4
Molecular Weight:
241.28
MDL Number:
MFCD00050404
MOL File:
14464-30-3.mol
Last updated:2023-10-30 14:43:20

2,5-Dioxopyrrolidin-1-yl octanoate Properties

Melting point 61-63 °C
Boiling point 333.2±25.0 °C(Predicted)
Density 1.13±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25

2,5-Dioxopyrrolidin-1-yl octanoate price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D487145 (2,5-Dioxopyrrolidin-1-yl)Octanoate 14464-30-3 250mg $40 2021-12-16 Buy
Matrix Scientific 178726 Caprylic acid N-succinimidyl ester 14464-30-3 10g $1156 2021-12-16 Buy
Matrix Scientific 178726 Caprylic acid N-succinimidyl ester 14464-30-3 25g $1980 2021-12-16 Buy
Ambeed A386850 2,5-Dioxopyrrolidin-1-yloctanoate 97% 14464-30-3 250mg $10 2021-12-16 Buy
Ambeed A386850 2,5-Dioxopyrrolidin-1-yloctanoate 97% 14464-30-3 1g $17 2021-12-16 Buy
Product number Packaging Price Buy
D487145 250mg $40 Buy
178726 10g $1156 Buy
178726 25g $1980 Buy
A386850 250mg $10 Buy
A386850 1g $17 Buy

2,5-Dioxopyrrolidin-1-yl octanoate Chemical Properties,Uses,Production

Uses

(2,5-Dioxopyrrolidin-1-yl) Octanoate is used in preparation of eliglustat and tartrate thereof.

Preparation

N-hydroxysuccinimide (Aldrich, 20.0 g, 173 mmol) and triethyl amine (29 mL, 208 mmol) were dissolved in methylene chloride in an ice bath under nitrogen. Octanoyl chloride (Aldrich, 35 mL, 205 mmol) was added dropwise over a period of 0.5 hours. The ice bath was then removed, and the resulting solution containing a white solid was stirred for 1 hour at room temperature. The white solid was separated by filtration, and the filtrate was subsequently washed with water (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was then dried using sodium sulfate, filtered, and heptane (100 mL) was added. The resulting solution was subjected to rotoevaporation to remove most of the methylene chloride, resulting in the formation of a colorless to white flaky precipitate in heptane. The precipitate was filtered and washed with heptane. After drying, 2,5-Dioxopyrrolidin-1-yl octanoate was obtained in a yield of 84%.
CAPRYLIC ACID N-SUCCINIMIDYL ESTER

2,5-Dioxopyrrolidin-1-yl octanoate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 85)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806 sales@capot.com China 29791 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32820 60
Shenzhen Excellent Biotech Co., Ltd.
13480692018 ramyan@ex-biotech.com CHINA 954 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29815 58
Shanghai Gubang New Materail Technology Co. LTD
21-51317962 +8618721305404 16728589@qq.com CHINA 272 58
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15361 58
LEAP CHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 24727 58
Hongxiong
+undefined18915499068 Suzhouhongxiong@163.com China 120 58
ZHEJIANG JIUZHOU CHEM CO., LTD
+86-0576225566889 +86-13454675544 admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com China 12272 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58

View Lastest Price from 2,5-Dioxopyrrolidin-1-yl octanoate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,5-dioxopyrrolidin-1-yl octanoate pictures 2024-02-13 2,5-dioxopyrrolidin-1-yl octanoate
14464-30-3
US $900.00 / g 1g 98 500 Kg R&D Scientific Inc.
CAPRYLIC ACID N-SUCCINIMIDYL ESTER pictures 2020-01-09 CAPRYLIC ACID N-SUCCINIMIDYL ESTER
14464-30-3
US $2.00 / KG 1g 98%min ask Career Henan Chemical Co
Caprylic acid-N-hydroxysuccinimide ester N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate Eliglustat intermediate 6 2,5-dioxopyrrolidin-1-yl octanoate 1-(Octanoyloxy)-2,5-pyrrolidinedione Octanoic acid-N-succinimidyl ester Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester Eliglustat Impurity 11 Octanoic acid N-hydroxy succinimide ester 14464-30-3