2,5-Dioxopyrrolidin-1-yl octanoate
- CAS No.
- 14464-30-3
- Chemical Name:
- 2,5-Dioxopyrrolidin-1-yl octanoate
- Synonyms
- Eliglustat Impurity 11;Eliglustat intermediate 6;2,5-dioxopyrrolidin-1-yl octanoate;Octanoic acid-N-succinimidyl ester;1-(Octanoyloxy)-2,5-pyrrolidinedione;Caprylic acid-N-hydroxysuccinimide ester;Octanoic acid N-hydroxy succinimide ester;Octanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Octanoic acid 2,5-dioxo-pyrrolidin-1-yl ester;N-(Octanoyloxy)succinimide, N-Succinimidyl caprylate, N-Succinimidyl octanoate
- CBNumber:
- CB9497580
- Molecular Formula:
- C12H19NO4
- Molecular Weight:
- 241.28
- MDL Number:
- MFCD00050404
- MOL File:
- 14464-30-3.mol
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
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2,5-Dioxopyrrolidin-1-yl octanoate price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | D487145 | (2,5-Dioxopyrrolidin-1-yl)Octanoate | 14464-30-3 | 250mg | $40 | 2021-12-16 | Buy |
Matrix Scientific | 178726 | Caprylic acid N-succinimidyl ester | 14464-30-3 | 10g | $1156 | 2021-12-16 | Buy |
Matrix Scientific | 178726 | Caprylic acid N-succinimidyl ester | 14464-30-3 | 25g | $1980 | 2021-12-16 | Buy |
Ambeed | A386850 | 2,5-Dioxopyrrolidin-1-yloctanoate 97% | 14464-30-3 | 250mg | $10 | 2021-12-16 | Buy |
Ambeed | A386850 | 2,5-Dioxopyrrolidin-1-yloctanoate 97% | 14464-30-3 | 1g | $17 | 2021-12-16 | Buy |
2,5-Dioxopyrrolidin-1-yl octanoate Chemical Properties,Uses,Production
Uses
(2,5-Dioxopyrrolidin-1-yl) Octanoate is used in preparation of eliglustat and tartrate thereof.
Preparation
N-hydroxysuccinimide (Aldrich, 20.0 g, 173 mmol) and triethyl amine (29 mL, 208 mmol) were dissolved in methylene chloride in an ice bath under nitrogen. Octanoyl chloride (Aldrich, 35 mL, 205 mmol) was added dropwise over a period of 0.5 hours. The ice bath was then removed, and the resulting solution containing a white solid was stirred for 1 hour at room temperature. The white solid was separated by filtration, and the filtrate was subsequently washed with water (100 mL) and saturated aqueous sodium bicarbonate (100 mL). The organic layer was then dried using sodium sulfate, filtered, and heptane (100 mL) was added. The resulting solution was subjected to rotoevaporation to remove most of the methylene chloride, resulting in the formation of a colorless to white flaky precipitate in heptane. The precipitate was filtered and washed with heptane. After drying, 2,5-Dioxopyrrolidin-1-yl octanoate was obtained in a yield of 84%.
2,5-Dioxopyrrolidin-1-yl octanoate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29815 | 58 |
Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | 16728589@qq.com | CHINA | 272 | 58 |
AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15361 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
Hongxiong | +undefined18915499068 | Suzhouhongxiong@163.com | China | 120 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 12272 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from 2,5-Dioxopyrrolidin-1-yl octanoate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-02-13 | 2,5-dioxopyrrolidin-1-yl octanoate
14464-30-3
|
US $900.00 / g | 1g | 98 | 500 Kg | R&D Scientific Inc. | ||
2020-01-09 | CAPRYLIC ACID N-SUCCINIMIDYL ESTER
14464-30-3
|
US $2.00 / KG | 1g | 98%min | ask | Career Henan Chemical Co |
- 2,5-dioxopyrrolidin-1-yl octanoate
14464-30-3
- US $900.00 / g
- 98
- R&D Scientific Inc.
- CAPRYLIC ACID N-SUCCINIMIDYL ESTER
14464-30-3
- US $2.00 / KG
- 98%min
- Career Henan Chemical Co
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