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CONCANAMYCIN A

CONCANAMYCIN A
CONCANAMYCIN A structure
CAS No.
80890-47-7
Chemical Name:
CONCANAMYCIN A
Synonyms
S-45A;A661-I;x4357b;FOLIMYCIN;NSC 674620;Concanamycin;CONCANAMYCIN A;A,ConcanaMycin;Antibiotic S-45A;Antibiotic A661I
CBNumber:
CB9696475
Molecular Formula:
C46H75NO14
Formula Weight:
866.09
MOL File:
80890-47-7.mol

CONCANAMYCIN A Properties

Melting point:
179-180℃ (dichloromethane ethanol )
Boiling point:
966.4±65.0 °C(Predicted)
Density 
1.20±0.1 g/cm3(Predicted)
storage temp. 
−20°C
form 
Lyophilized solid
pka
12.46±0.70(Predicted)
BRN 
3560277
EWG's Food Scores
1
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300+H310+H330-H319
Precautionary statements  P260-P264-P280-P284-P301+P310-P302+P350
Hazard Codes  T+
Risk Statements  26/27/28-36
Safety Statements  26-36/37/39-45
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  CB9732000
10-21
HazardClass  6.1(b)
PackingGroup  III

CONCANAMYCIN A price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 344085 Folimycin, Streptomyces sp. - CAS 80890-47-7 - Calbiochem A highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM). 80890-47-7 10 μg $119.32 2021-12-16 Buy
Sigma-Aldrich C9705 Concanamycin A ≥70% (HPLC) 80890-47-7 25 μg $161 2021-12-16 Buy
Sigma-Aldrich 27689 Concanamycin A from 80890-47-7 50ug $348 2021-12-16 Buy
Sigma-Aldrich C9705 Concanamycin A ≥70% (HPLC) 80890-47-7 0.1 mg $500 2021-12-16 Buy
Sigma-Aldrich 27689 Concanamycin A from 80890-47-7 250ug $1150 2021-12-16 Buy

CONCANAMYCIN A Chemical Properties,Uses,Production

Uses

Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp.. It has been shown to act as a potent and specific vacuolar-ATPase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins.

Uses

Concanamycin A has been used:
  • as a lysosomal inhibitor in young and old fibroblasts
  • as a vacuolar-type H+-ATPase inhibitor in presynaptic vesicles
  • as a lysosomal acidification blocker in HepG2 hepatocytes cells

Definition

ChEBI: A concanamycin in which the lactone ring contains 4 double bonds and is substituted by 4 methyl groups, 2 hydroxy groups, 2 methoxy groups and an ethyl group.

General Description

Chemical structure: macrolide

Biological Activity

Specific inhibitor of V-type (vacuolar) H + -ATPase that displays > 2000-fold selectivity over other H + -ATPases (IC 50 values are 9.2, > 20000, > 20000 and > 20000 nM for yeast V-type, F-type, P-type H + -ATPases and porcine P-type Na + ,K + -ATPase respectively). Blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines.

Biochem/physiol Actions

Concanamycin A (ConA) inhibits acidification of organelles and perforin-mediated cytotoxicity. It is a vacuolar-type v-ATPase inhibitor. ConA possesses antiprotozoal and antineoplastic properties. It mediates inhibition of the negative factor (Nef) protein of the human immunodeficiency virus.

CONCANAMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products


CONCANAMYCIN A Suppliers

Global( 78)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd
15336106720
029-88380327 1017@dideu.com CHINA 3979 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19231 58
Shaanxi Dideu Medichem Co. Ltd
18192503167 +86-29-89586680
+86-29-88380327 1005@dideu.com CHINA 9938 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
BOC Sciences
16314854226
inquiry@bocsci.com United States 19674 58
Shanghai Hongye Biotechnology Co. Ltd 400-920-5774
sales@glpbio.cn China 6881 58
Nanjing Shizhou Biology Technology Co.,Ltd 13675144456 025-85560043-
025-85563444 sean.lv@synzest.com China 11452 58
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 821-50328103-801
86-21-50328109 3bsc@sina.com China 15877 69
Hunan Hui Bai Shi Biotechnology Co., Ltd. 13308475853 0731-85526065-
3002732518@qq.com China 3506 62

View Lastest Price from CONCANAMYCIN A manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-06-25 CONCANAMYCIN A USP/EP/BP
80890-47-7
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
2020-05-10 Concanamycin A
80890-47-7
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd

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