Benzene, 1-(phenylseleno)-4-(trifluoromethyl)-
- CAS No.
- 227010-33-5
- Chemical Name:
- Benzene, 1-(phenylseleno)-4-(trifluoromethyl)-
- Synonyms
- LDHA-IN-3;Benzene, 1-(phenylseleno)-4-(trifluoromethyl)-
- CBNumber:
- CB98686997
- Molecular Formula:
- C13H9F3Se
- Molecular Weight:
- 301.17
- MDL Number:
- MOL File:
- 227010-33-5.mol
Benzene, 1-(phenylseleno)-4-(trifluoromethyl)- Chemical Properties,Uses,Production
Biological Activity
LDHA-IN-3, as a selenobenzene compound, is a potent, noncompetitive lactate dehydrogenase (LDHA) inhibitor (IC50=145.2 nM). LDHA-IN-3 can be used for the research of cancer[1]. PSTMB (0~500 μM; 48 hours; MCF-7 cells) shows cytotoxic effect[1].PSTMB (0.01~1 μM) shows dose-dependent inhibition of LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage[1].PSTMB can bind to LDHA protein efficiently. PSTMB induces the intrinsic pathway-mediated apoptosis of cancer cells via production of mitochondrial ROS[1].
References
[1]. Kim EY, et al. A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-4-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Cell Death. Sci Rep. 2019;9(1):3969. Published 2019 Mar 8.
Benzene, 1-(phenylseleno)-4-(trifluoromethyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzene, 1-(phenylseleno)-4-(trifluoromethyl)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| TargetMol Chemicals Inc. | 58 |
| RD International Technology Co., Limited | 58 |