fenbutrazate
- CAS No.
- 4378-36-3
- Chemical Name:
- fenbutrazate
- Synonyms
- fenbutrazate;Fenbutrazatum;Phenbutrazate;Phenbutrazatum;fenbutrazate USP/EP/BP;2-(3-Methyl-2-phenylMorpholino)ethyl 2-Phenylbutyrate;2-(3-Methyl-2-phenylmorpholino)ethyl 2-phenylbutanoate;2-(3-methyl-2-phenylmorpholin-4-yl)ethyl 2-phenylbutanoate;2-(3-methyl-2-phenyl-morpholin-4-yl)ethyl 2-phenylbutanoate;2-Phenylbutyric acid 2-(3-methyl-2-phenylmorpholino)ethyl ester
- CBNumber:
- CB9900958
- Molecular Formula:
- C23H29NO3
- Molecular Weight:
- 367.48
- MDL Number:
- MFCD00864478
- MOL File:
- 4378-36-3.mol
- MSDS File:
- SDS
| Boiling point | bp0.05 235-240° |
|---|---|
| solubility | Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Oil to Thick Oil |
| color | Pale Yellow to Very Dark Orange |
| FDA UNII | BKY8H56395 |
fenbutrazate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 011959 | Fenbutrazate | 4378-36-3 | 10mg | $475 | 2021-12-16 | Buy |
| TRC | F247250 | Fenbutrazate | 4378-36-3 | 100mg | $1555 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002684 | FENBUTRAZATE 95.00% | 4378-36-3 | 100MG | $2055.9 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 57998 | Fenbutrazate | 4378-36-3 | 10mg | $660 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0002684 | FENBUTRAZATE 95.00% | 4378-36-3 | 10MG | $762.3 | 2021-12-16 | Buy |
fenbutrazate Chemical Properties,Uses,Production
Originator
Phenbutrazate,Shanghai Lansheng
Uses
Fenbutrazate is a derivative of Phenmetrazine (P314500). Fenbutrazate is a psychostimulant used as an anorexigen (appetite suppressant).
Definition
ChEBI: Fenbutrazate is a member of morpholines.
Manufacturing Process
1105 g of 2-phenyl-3-methyl-4-(α-hydroxyethyl)-tetrahydro-1,4-oxazine-(4- (2-hydroxyethyl)-3-methyl-2-phenylmorphotine) are dissolved in 4000 ml of anhydrous toluene. 910 g of α-phenyl-α-ethyl acetic acid chloride (2-ethyl-2- phenyl-acetylchloride) are dissolved in 400 ml of anhydrous toluene and the resulting solution is slowly added to the heated solution of the tetrahydro-1,4- oxazine compound. The mixture is then heated to boiling for about 5 hours. About 1000 g of ice are added to the cooled reaction mixture, which is then rendered alkaline by the addition of 20% sodium carbonate solution to a pH of 9.0. Thereafter the mixture is vigorously stirred by means of a turbine mixer for one hour and the toluene phase is separated. The toluene solution is washed with 1000 ml of saturated sodium chloride solution and is dried over anhydrous sodium sulfate. The toluene is then evaporated and the residue is subjected to high vacuum distillation. 1650 g of α-phenyl-α-ethylacetic acid (2-phenyl-3-methyltetrahydro-1,4-oxazine)-N-ethyl ester (fenburazate), boiling at 235°-240°C/0.05 mm are obtained thereby in a yield of 90.5% of the theoretical yield.
Therapeutic Function
Anorexic, Central stimulant
Synthesis
Phenbutrazate is prepared by condensing Nhydroxyethylphenmetrazine (R = CH2CH2OH) with 2-phenylbutyric acid. The N-hydroxyethyl compound is obtained in the same manner as phendimetrazine .
fenbutrazate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| LGC Science (Shanghai) Ltd. | 17717235263 | cindy.yang@lgcgroup.com | China | 11437 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | malulu@leyan.com | China | 40041 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 58 |
| Chemsky（shanghai）International Co.,Ltd. | 50 |
| LGC Science (Shanghai) Ltd. | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 58 |