Lithium dodecyl sulfate
- CAS No.
- 2044-56-6
- Chemical Name:
- Lithium dodecyl sulfate
- Synonyms
- LDS;hMAD;LITHIUM LAURYL SULPHATE;LiDS;JV15;hSMAD;hMAD-3;hSMAD3;MAD homolog;Press-on Lids
- CBNumber:
- CB0150488
- Molecular Formula:
- C12H25LiO4S
- Molecular Weight:
- 272.33
- MOL File:
- 2044-56-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2026/5/27 17:21:29
| Melting point | 100-123 °C |
|---|---|
| Boiling point | 199℃[at 101 325 Pa] |
| Density | 1.168[at 20℃] |
| vapor pressure | 6.5Pa at 20℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 0.1 M at 20 °C, clear, colorless |
| form | Shiny Crystalline Flakes or Powder |
| color | White |
| PH | pH(0.25mol/l, 25℃) : 5.0～10.5 |
| Appearance | White to Almost white powder to crystal. |
| Water Solubility | Soluble in water. |
| BRN | 5186718 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChI | InChI=1S/C12H26O4S.Li/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1 |
| InChIKey | YFVGRULMIQXYNE-UHFFFAOYSA-M |
| SMILES | C(COS([O-])(=O)=O)CCCCCCCCCC.[Li+] |
| CAS DataBase Reference | 2044-56-6(CAS DataBase Reference) |
| EPA Substance Registry System | Sulfuric acid, monododecyl ester, lithium salt (2044-56-6) |
| Absorption |
≤0.05 at 260nm (3% solution) ≤0.05 at 280nm (3% solution) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H228-H315-H318-H335 | |||||||||
| Precautionary statements | P210-P280-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,C,F | |||||||||
| Risk Statements | 36/37/38-34-20/21/22-15-14-11-41-37/38 | |||||||||
| Safety Statements | 26-36-45-43-36/37/39-16-7/8-3/7/9-39 | |||||||||
| RIDADR | UN1325 - class 4.1 - PG 3 - Flammable solids, organic, n.o.s., HI: all | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 4.1 | |||||||||
| HS Code | 29209010 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 3 Eye Dam. 1 Flam. Sol. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Lithium dodecyl sulfate price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | L9781 | Lithium dodecyl sulfate BioReagent, for molecular biology, suitable for electrophoresis | 2044-56-6 | 5G | ₹3842.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L9781 | Lithium dodecyl sulfate BioReagent, for molecular biology, suitable for electrophoresis | 2044-56-6 | 25G | ₹9753.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L9781 | Lithium dodecyl sulfate BioReagent, for molecular biology, suitable for electrophoresis | 2044-56-6 | 50G | ₹19127.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L5901 | Lithium dodecyl sulfate BioXtra, ≥98.5% (GC) | 2044-56-6 | 5G | ₹5196 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | L4632 | Lithium dodecyl sulfate ≥98.5% (GC) | 2044-56-6 | 5G | ₹2294.9 | 2022-06-14 | Buy |
Lithium dodecyl sulfate Chemical Properties,Uses,Production
Description
Lithium dodecyl sulfate (LDS) is an anionic detergent and surfactant that is frequently used in electrophoresis and chromatography. LDS may be substituted for sodium dodecyl sulfate (SDS) in electrophoresis under cold conditions. The use of LDS in micellar electrokinetic chromatography has been extensively studied. A report has been published on the partition equilibria of LDS between water and bilayer membranes. LDS has been utilized in protein electrophoresis and proteomics studies. The three-dimensional structure of the amyloid β-protein fragment 25-35 has been investigated in LDS micelles by two-dimensional 1HNMR. LDS has been used to induce changes in protein conformation.
Chemical Properties
Lithium dodecyl sulfate is a white, shiny crystalline powder or flake, soluble in organic solvents such as alcohols, ethers, and hydrocarbons, but only slightly soluble in water. It exhibits good thermal stability and remains stable at room temperature. As an anionic surfactant, it demonstrates excellent surface activity.
Uses
Lithium dodecyl sulfate has been used as a component of lysis buffer.
Purification Methods
Recrystallise this detergent twice from absolute EtOH and dry it under vacuum. Critical Micellar Concentration (CMC) in H2O is 8.77 x 10-3M. [Mukerjee et al. J Phys Chem 71 4166 1967, Mysels & Dulin J Colloid Sci 10 461 1955, Beilstein 1 IV 1847.]
Precautions
In general, autoclaved lauryl sulfate solutions undergo hydrolysis to yield lauryl alcohol, which precipitates from solution, and sulfuric acid, which decreases the solution pH. It is not advised to autoclave lauryl sulfate solutions.
References
[1] ELISABET FUGUET. Solute−Solvent Interactions in Micellar Electrokinetic Chromatography. 6. Optimization of the Selectivity of Lithium Dodecyl Sulfate−Lithium Perfluorooctanesulfonate Mixed Micellar Buffers[J]. Analytical Chemistry, 2002, 74 17: 4447-4455. DOI:10.1021/ac0201530.
[2] M D TRONE. Characterization of chemical selectivity in micellar electrokinetic chromatography. VI. Effects of surfactant counter-ion.[J]. Journal of Chromatography A, 2000, 888 1-2: 229-240. DOI:10.1016/s0021-9673(00)00515-x.
[3] GARY H. PERDEW Daniel P S Henry W Schaup. The use of a zwitterionic detergent in two-dimensional gel electrophoresis of trout liver microsomes[J]. Analytical biochemistry, 1983, 135 2: Pages 453-455. DOI:10.1016/0003-2697(83)90711-X.
[4] SHINJI KONDOU. Concentrated Lithium Dodecyl Sulfate Aqueous Electrolytes: Utilizing Self-Assembly and Interfacial Adsorption for Aqueous Li-ion Batteries[J]. ChemElectroChem, 2022, 9 20. DOI:10.1002/celc.202200870.
Lithium dodecyl sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6749 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6888 | 58 | Inquiry |
| Triveni chemicals | 08048762458 | Beijing, India | 6080 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2330 | 58 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1605 | 58 | Inquiry |
| Sisco Research Laboratories Pvt. Ltd. | +91-22-4268 5800 | Mumbai, India | 4312 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | Beijing, India | 6683 | 30 | Inquiry |
| HiMedia Laboratories | 91-22-61471919 | Maharashtra, India | 1839 | 58 | Inquiry |
| Sisco Resech Laboratories Private Limited | +91-22-4268 5800 | Mumbai, India | 655 | 58 | Inquiry |
| OpChem(Changzhou) Co.,Ltd. | +86-18112346326 | China | 975 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Triveni chemicals | 58 |
| Anand Agencies | 58 |
| Maas Pharma Chemicals | 58 |
| Sisco Research Laboratories Pvt. Ltd. | 58 |
| CHEMSWORTH | 30 |
| HiMedia Laboratories | 58 |
| Sisco Resech Laboratories Private Limited | 58 |
| OpChem(Changzhou) Co.,Ltd. | 58 |
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