Estriol
- CAS No.
- 50-27-1
- Chemical Name:
- Estriol
- Synonyms
- E 3;OVESTIN;16α-Estriol;ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL;(16alpha,17beta)-Estra-1,3,5(10)-triene-3,16,17-triol;1,3,5(10)-Estratriene-3,16α,17β-triol, 16α-Hydroxyestradiol, 3,16α,17β-Trihydroxy-1,3,5(10)-estratriene;Estriol,1,3,5(10)-Estratriene-3,16α,17β-triol, 16α-Hydroxyestradiol, 3,16α,17β-Trihydroxy-1,3,5(10)-estratriene;(8R,9S,13S,14S,16R,17R)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,16,17-triol;OE3;Holin
- CBNumber:
- CB1687589
- Molecular Formula:
- C18H24O3
- Molecular Weight:
- 288.38
- MOL File:
- 50-27-1.mol
- Modify Date:
- 2024/5/6 18:26:58
| Melting point | 280-282 °C(lit.) |
|---|---|
| alpha | D25 +58° ±5° (0.04 g in 1 ml dioxane) |
| Boiling point | 370.61°C (rough estimate) |
| Density | 1.27 |
| refractive index | 58 ° (C=0.4, Dioxane) |
| Flash point | 9℃ |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, sparingly soluble in ethanol (96 per cent). |
| pka | pKa 10.38±0.02(H2O t=23±2 Iunspeci?ed) (Uncertain) |
| color | White to Off-White |
| Water Solubility | 3.2mg/L(25 ºC) |
| Merck | 3707 |
| BRN | 2508172 |
| InChIKey | PROQIPRRNZUXQM-ZXXIGWHRSA-N |
| CAS DataBase Reference | 50-27-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Estriol(50-27-1) |
| EPA Substance Registry System | Estriol (50-27-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H351-H360FD-H362 | |||||||||
| Precautionary statements | P201-P202-P260-P263-P264-P308+P313 | |||||||||
| Hazard Codes | T,F | |||||||||
| Risk Statements | 60-61-40-45-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 53-22-36/37/39-45-36/37-16 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | KG8225000 | |||||||||
| F | 8-10 | |||||||||
| HS Code | 29072990 | |||||||||
| Toxicity | LD50 oral in rat: > 2gm/kg | |||||||||
| NFPA 704 |
|
Estriol price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | E1253 | Estriol ≥97% | 50-27-1 | 100MG | ₹6462.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E1253 | Estriol ≥97% | 50-27-1 | 500MG | ₹7902.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2800 | Estriol certified reference material, pharmaceutical secondary standard | 50-27-1 | 200MG | ₹22342.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E1253 | Estriol ≥97% | 50-27-1 | 1G | ₹12199.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E1149 | Estriol meets USP testing specifications | 50-27-1 | 1G | ₹11387.9 | 2022-06-14 | Buy |
Estriol Chemical Properties,Uses,Production
Description
Estriol is significantly less active than estradiol; however, it has a selective ability to stimulate blood flow and restoration of genital epithelium. In addition, using this drug reduces mental symptoms of menopausal syndrome. It is used in the premenopausal and menopausal periods, for skin atrophy and signs of genital degeneration, and so on.
Chemical Properties
White or almost white, crystalline powder.
Uses
A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol
Definition
ChEBI: A 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer).
General Description
Estriol, estra-1,3,5(10)-triene-3,16 ,17 -triol, is available for compounding into several differentformulations for use in HRT. It can be used alone or in combinationswith estradiol (Bi-Est) or with estradiol and estrone(Tri-Est).
Hazard
A carcinogen (OSHA).
Safety Profile
Suspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Other experimental reproductive effects. Mutation data reported. A steroid drug for the treatment of menopause. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Crystallise estriol from EtOH/ethyl acetate. Also purify it by countercurrent distribution with cyclohexane/EtOAc (1:1) and EtOH/H2O (1:1). The UV (EtOH) has max at 280nm ( 2,090 M-1cm-1). [Huffmann & Lott 71 719 1949, Leeds et al. J Am Chem Soc 76 2943 1954, Beilstein 6 IV 7550.]
Estriol Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Asg Biochem Pvt. Ltd | +91-9650436669 +91-9650436669 | New Delhi, India | 25 | 58 | Inquiry |
| Vincit Labs Pvt Ltd | +91-1127357490 +91-1127357490 | New Delhi, India | 15 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| ASG Biochem Pvt. Ltd | 09432255551 | Delhi, India | 3 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Ralington Pharma | 58 |
| Asg Biochem Pvt. Ltd | 58 |
| Vincit Labs Pvt Ltd | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| ASG Biochem Pvt. Ltd | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| SynZeal Research Pvt Ltd | 58 |
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