7α,25-dihydroxy Cholesterol
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- CAS番号.
- 64907-22-8
- 化学名:
- 7α,25-dihydroxy Cholesterol
- 别名:
- 7α,25-dihydroxy Cholesterol;コレスタ-5-エン-3β,7α,25-トリオール;(1R,3aS,3bS,4S,7S,9aR,9bS,11aR)-1-[(2R)-6-ヒドロキシ-6-メチルヘプタン-2-イル]-9a,11a-ジメチル-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-シクロペンタ[a]フェナントレン-4,7-ジオール;7α,25-ジヒドロキシコレステロール
- 英語名:
- 7α,25-dihydroxy Cholesterol
- 英語别名:
- 7Α;7α,25-OHC;Cholesterol Impurity 33;25-dihydroxycholesterol;5-Cholesten-3β,7α,25-triol;7α,25-dihydroxy Cholesterol;7-alpha,25-Dihydroxycholesterol;3β,7α,25-Trihydroxycholest-5-ene;3β,7α,25-Trihydroxycholest-5-ene;(3β,7α)-Cholest-5-ene-3,7,25-triol
- CBNumber:
- CB01235638
- 化学式:
- C27H46O3
- 分子量:
- 418.65
- MOL File:
- 64907-22-8.mol
- MSDS File:
- SDS
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7α,25-dihydroxy Cholesterol 物理性質
- 沸点 :
- 548.5±35.0 °C(Predicted)
- 比重(密度) :
- 1.08±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：ソリュブル5mg/mL（透明溶液）
- 外見 :
- 粉
- 酸解離定数(Pka):
- 14.11±0.70(Predicted)
- 色:
- 白からベージュ
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
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| 注意喚起語 |
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| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H413 |
長期的影響により水生生物に有害のおそれ |
水生環境有害性、慢性毒性 |
4 |
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| 注意書き |
| P273 |
環境への放出を避けること。 |
| P501 |
内容物/容器を．．．に廃棄すること。 |
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7α,25-dihydroxy Cholesterol 価格
もっと(7)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TRCT795075 |
3β,7α,25-Trihydroxycholest-5-ene |
64907-22-8 |
2.5mg |
￥41300 |
2023-06-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TRCT795075 |
3β,7α,25-Trihydroxycholest-5-ene |
64907-22-8 |
5mg |
￥74300 |
2023-06-01 |
購入 |
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Sigma-Aldrich Japan
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SML0541 |
7α,25-ジヒドロキシコレステロール ≥98% (HPLC)
7α,25-Dihydroxycholesterol ≥98% (HPLC) |
64907-22-8 |
5mg |
￥83700 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
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700080P |
powder
7α,25-dihydroxycholesterol powder |
64907-22-8 |
1mg |
￥71000 |
2024-03-01 |
購入 |
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富士フイルム和光純薬株式会社(wako)
|
W01TRCT795075 |
3β,7α,25-Trihydroxycholest-5-ene |
64907-22-8 |
10mg |
￥137500 |
2023-06-01 |
購入 |
7α,25-dihydroxy Cholesterol 化学特性,用途語,生産方法
使用
GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production. 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM). At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays. 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.[Cayman Chemical]
一般的な説明
7α,25-dihydroxycholesterol (7α,25-OHC) is synthesized by the hydroxylation of cholesterol by the action of enzyme cholesterol 25-hydroxylase (CH25H) and cytochrome P450, family 7, subfamily b, polypeptide 1 (CYP7B1). The catabolic breakdown of 7α,25-OHC to bile acid precursors is catalyzed by the enzymes hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase 7 (HSD3B7).
Biochem/physiol Actions
7α,25-dihydroxycholesterol (7α,25-OHC) serves as an endogenous ligand for G-protein-coupled receptor 183 (GPR183) or Epstein-Barr virus-induced gene 2 (EBI2). It plays a key role in the migration of type 3 innate lymphoid cells (ILC3) in the small intestine and colon. 7α,25-OHC mediates immune cell migration functionality by their chemoattractant property. Inhibition of 7α,25-OHC synthesis leads to impairment in the migration of B cells.
7α,25-dihydroxy Cholesterol 上流と下流の製品情報
原材料
準備製品
7α,25-dihydroxy Cholesterol 生産企業
Global( 36)Suppliers
- 64907-22-8
- 7-alpha,25-Dihydroxycholesterol
- 3β,7α,25-Trihydroxycholest-5-ene
- 5-Cholesten-3β,7α,25-triol
- 25-dihydroxycholesterol
- 7Α,25-DIHYDROXYCHOLESTEROL;7Α;25-DIHYDROXYCHOLESTEROL
- (3β,7α)-Cholest-5-ene-3,7,25-triol
- 7α,25-OHC
- 7α,25-dihydroxy Cholesterol
- 7Α
- Cholesterol Impurity 33
- 3β,7α,25-Trihydroxycholest-5-ene
- endogenous,response,oxysterols,Endogenous Metabolite,GPCR,EBI2/GPR183,ligand,7α,25 Dihydroxycholesterol,receptor,Inhibitor,immune,7α,25-Dihydroxycholesterol,migration,7α,25Dihydroxycholesterol,cells,inhibit
- Cholest-5-ene-3,7,25-triol, (3β,7α)-
- 7α,25-dihydroxy Cholesterol
- コレスタ-5-エン-3β,7α,25-トリオール
- (1R,3aS,3bS,4S,7S,9aR,9bS,11aR)-1-[(2R)-6-ヒドロキシ-6-メチルヘプタン-2-イル]-9a,11a-ジメチル-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-シクロペンタ[a]フェナントレン-4,7-ジオール
- 7α,25-ジヒドロキシコレステロール