7α,25-dihydroxy Cholesterol
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- CAS-Nr.
- 64907-22-8
- Englisch Name:
- 7α,25-dihydroxy Cholesterol
- Synonyma:
- 7Α;7α,25-OHC;Cholesterol Impurity 33;25-dihydroxycholesterol;5-Cholesten-3β,7α,25-triol;7α,25-dihydroxy Cholesterol;7-alpha,25-Dihydroxycholesterol;3β,7α,25-Trihydroxycholest-5-ene;3β,7α,25-Trihydroxycholest-5-ene;(3β,7α)-Cholest-5-ene-3,7,25-triol
- CBNumber:
- CB01235638
- Summenformel:
- C27H46O3
- Molgewicht:
- 418.65
- MOL-Datei:
- 64907-22-8.mol
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7α,25-dihydroxy Cholesterol Eigenschaften
- Siedepunkt:
- 548.5±35.0 °C(Predicted)
- Dichte
- 1.08±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: soluble5mg/mL (clear solution)
- Aggregatzustand
- powder
- pka
- 14.11±0.70(Predicted)
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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7α,25-dihydroxy Cholesterol Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production. 7α,25-dihydroxy Cholesterol (7α,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM). At concentrations below 3 μM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays. 7α,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo.[Cayman Chemical]
Allgemeine Beschreibung
7α,25-dihydroxycholesterol (7α,25-OHC) is synthesized by the hydroxylation of cholesterol by the action of enzyme cholesterol 25-hydroxylase (CH25H) and cytochrome P450, family 7, subfamily b, polypeptide 1 (CYP7B1). The catabolic breakdown of 7α,25-OHC to bile acid precursors is catalyzed by the enzymes hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase 7 (HSD3B7).
Biochem/physiol Actions
7α,25-dihydroxycholesterol (7α,25-OHC) serves as an endogenous ligand for G-protein-coupled receptor 183 (GPR183) or Epstein-Barr virus-induced gene 2 (EBI2). It plays a key role in the migration of type 3 innate lymphoid cells (ILC3) in the small intestine and colon. 7α,25-OHC mediates immune cell migration functionality by their chemoattractant property. Inhibition of 7α,25-OHC synthesis leads to impairment in the migration of B cells.
7α,25-dihydroxy Cholesterol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
7α,25-dihydroxy Cholesterol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 36)Lieferanten
- 7-alpha,25-Dihydroxycholesterol
- 3β,7α,25-Trihydroxycholest-5-ene
- 5-Cholesten-3β,7α,25-triol
- 25-dihydroxycholesterol
- 7Α,25-DIHYDROXYCHOLESTEROL;7Α;25-DIHYDROXYCHOLESTEROL
- (3β,7α)-Cholest-5-ene-3,7,25-triol
- 7α,25-OHC
- 7α,25-dihydroxy Cholesterol
- 7Α
- Cholesterol Impurity 33
- 3β,7α,25-Trihydroxycholest-5-ene
- endogenous,response,oxysterols,Endogenous Metabolite,GPCR,EBI2/GPR183,ligand,7α,25 Dihydroxycholesterol,receptor,Inhibitor,immune,7α,25-Dihydroxycholesterol,migration,7α,25Dihydroxycholesterol,cells,inhibit
- Cholest-5-ene-3,7,25-triol, (3β,7α)-
- 64907-22-8
