ベルニナマイシンA

ベルニナマイシンA 化学構造式
58798-97-3
CAS番号.
58798-97-3
化学名:
ベルニナマイシンA
别名:
N-(1-カルバモイルエタ-1-エン-1-イル)-2-{[17-エチリデン-14-(1-ヒドロキシエチル)-27-(2-ヒドロキシプロパン-2-イル)-20,33-ジメチル-24,30,37,40-テトラメチリデン-12,15,22,25,28,35,38-ヘプタオキソ-19,32,42-トリオキサ-9-チア-3,13,16,23,26,29,36,39,44,45,46,47-ドデカアザヘキサシクロ[39.2.1.18,11.118,21.131,34.02,7]ヘプタテトラコンタ-1(43),2,4,6,8(47),10,18(46),20,31(45),33,41(44)-ウンデカエン-4-イル]ホルムアミド}プロパ-2-エンアミド;2-[[2-[[[2,5,12,15,18,25,28-ヘプタオキソ-4-(1-ヒドロキシエチル)-7-エチリデン-10,23-ジメチル-14,20,27,30-テトラキスメチレン-17-(1-ヒドロキシ-1-メチルエチル)-3,6,13,16,19,26,29,36,44,45,46,47-ドデカアザ-9,22,32-トリオキサ-42-チアヘキサシクロ[39.2.1.18,11.121,24.131,34.035,40]ヘプタテトラコンタン-1(43),8(47),10,21(46),23,31(45),33,35,37,39,41(44)-ウンデカエン-37-イル]カルボニル]アミノ]プロペノイル]アミノ]プロペンアミド;ベルニナマイシンA
英語名:
berninamycin A
英語别名:
Berninamycin;berninamycin A;BerninaMycin, U27810;Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro...
CBNumber:
CB01361481
化学式:
C51H51N15O15S
分子量:
1146.11
MOL File:
58798-97-3.mol

ベルニナマイシンA 物理性質

融点 :
>290°
貯蔵温度 :
Store at -20°C
溶解性:
Soluble in DMSO
外見 :
solid
色:
white

安全性情報

ベルニナマイシンA 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

ベルニナマイシンA 化学特性,用途語,生産方法

使用

Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic "peptide" comprising atypical amino acids linked to thiazole and oxazoles. Chemically very complex, berninamycin A is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, that are central to multidrug resistance. Berninamycin A is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

酵素阻害剤

This fungal antibiotic (FW = 1146.12 g/mol; CAS 58798-97-3; Soluble in DMSO), also known as Antibiotic U27810, from Streptomyces bernensis inhibits protein biosynthesis by binding to a complex formed by ribosomal 23S and the L11 protein, thereby disrupting the function of the ribosome’s A site and inhibiting protein synthesis in Gram-positive bacteria. In this respect, it has the same mode of action as thiostrepton. Streptomyces bernensis and Streptomyces azureus, which produce berninamycin and thiostrepton, respectively, possess similar ribosomal RNA methylases that mediate specific pentose-directed methylation of 23S ribosomal RNA, rendering the modified ribosomes resistant to these antibiotics.

ベルニナマイシンA 上流と下流の製品情報

原材料

準備製品


ベルニナマイシンA 生産企業

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  • 58798-97-3
  • berninamycin A
  • Berninamycin
  • BerninaMycin, U27810
  • Alaninamide, L-threonyl-2-[(1Z)-1-amino-1-propen-1-yl]-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-3-methyl-L-threonyl-2-(1-aminoethenyl)-5-methyl-4-oxazolecarbonyl-2,3-didehydroalanyl-6-[2-(1-aminoethenyl)-4-oxazolyl]-5-(4-carboxy-2-thiazolyl)-2-pyridinecarbonyl-2,3-didehydroalanyl-2,3-didehydro...
  • N-(1-カルバモイルエタ-1-エン-1-イル)-2-{[17-エチリデン-14-(1-ヒドロキシエチル)-27-(2-ヒドロキシプロパン-2-イル)-20,33-ジメチル-24,30,37,40-テトラメチリデン-12,15,22,25,28,35,38-ヘプタオキソ-19,32,42-トリオキサ-9-チア-3,13,16,23,26,29,36,39,44,45,46,47-ドデカアザヘキサシクロ[39.2.1.18,11.118,21.131,34.02,7]ヘプタテトラコンタ-1(43),2,4,6,8(47),10,18(46),20,31(45),33,41(44)-ウンデカエン-4-イル]ホルムアミド}プロパ-2-エンアミド
  • 2-[[2-[[[2,5,12,15,18,25,28-ヘプタオキソ-4-(1-ヒドロキシエチル)-7-エチリデン-10,23-ジメチル-14,20,27,30-テトラキスメチレン-17-(1-ヒドロキシ-1-メチルエチル)-3,6,13,16,19,26,29,36,44,45,46,47-ドデカアザ-9,22,32-トリオキサ-42-チアヘキサシクロ[39.2.1.18,11.121,24.131,34.035,40]ヘプタテトラコンタン-1(43),8(47),10,21(46),23,31(45),33,35,37,39,41(44)-ウンデカエン-37-イル]カルボニル]アミノ]プロペノイル]アミノ]プロペンアミド
  • ベルニナマイシンA
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