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5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

化学構造式
493028-20-9
CAS番号.
493028-20-9
化学名:
别名:
英語名:
5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
英語别名:
CBFβ Inhibitor;CBFβ Inhibitor;TIMTEC-BB SBB011699;Runx1-CBFβ interaction inhibitor 1;2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem;5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE;5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
CBNumber:
CB0412427
化学式:
C12H14N2OS
分子量:
234.32
MOL File:
Mol file

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE 物理性質

沸点 :
421.6±40.0 °C(Predicted)
比重(密度) :
1.192±0.06 g/cm3(Predicted)
貯蔵温度 :
+2C to +8C
溶解性:
DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
外見 :
黄褐色の固体
酸解離定数(Pka):
5.00±0.10(Predicted)

安全性情報

主な危険性  Xi
国連危険物分類  IRRITANT

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE 価格 もっと(1)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01MAS010287
5-Ethyl-4-(4-methoxy-phenyl)-thiazol-2-ylamine 		493028-20-9 1g ￥130200 2024-03-01 購入

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE 化学特性,用途語,生産方法

説明

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

使用

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE 上流と下流の製品情報

原材料

準備製品

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE 生産企業

Global( 30)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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Aladdin Scientific 		+1-833-552-7181
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BOC Sciences 16314854226
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Changzhou Hopschain Chemical Co.,Ltd. 0519-85528066 13775048983
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ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
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Shanghai Haohong Pharmaceutical Co., Ltd. 4008210725 4008210725
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MedBioPharmaceutical Technology Inc 021-69568360 18916172912
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Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
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TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24024 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715
 sales@szzxbio.com China 2981 58

  スペクトルデータ(1HNMR)

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE(493028-20-9)1HNMR
  • 493028-20-9
  • TIMTEC-BB SBB011699
  • 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE
  • CBFβ Inhibitor
  • 5-ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
  • CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem
  • CBFβ Inhibitor
  • 2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-
  • Runx1-CBFβ interaction inhibitor 1
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