IMD-0354
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- CAS番号.
- 978-62-1
- 化学名:
- 别名:
- 英語名:
- IMD-0354
- 英語别名:
- IMD 0354;IMD-0354;IMD-0354 USP/EP/BP;IKK-2 INHIBITOR V; IMD 0354;IMD0354;;IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem;IMD-0354, 99%, a synthetic selective NF-kB inhibitor;Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-;IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354;N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354
- CBNumber:
- CB0503637
- 化学式:
- C15H8ClF6NO2
- 分子量:
- 383.67
- MOL File:
- 978-62-1.mol
- MSDS File:
- SDS
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IMD-0354 物理性質
- 沸点 :
- 323.1±42.0 °C(Predicted)
- 比重(密度) :
- 1.561
- 貯蔵温度 :
- -20°C
- 溶解性:
- 溶解度: DMSO (5 mg/ml) またはエタノール (1 mg/ml)。
- 外見 :
- 白い固体
- 酸解離定数(Pka):
- 7.61±0.43(Predicted)
- Sensitive :
- Light Sensitive
- CAS データベース:
- 978-62-1
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
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W01TOC2611 |
IMD 0354 |
978-62-1 |
10mg |
￥64000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC2611 |
IMD 0354 |
978-62-1 |
50mg |
￥270000 |
2024-03-01 |
購入 |
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Sigma-Aldrich Japan
|
I3159 |
≥98% (HPLC), solid
IMD-0354 ≥98% (HPLC), solid |
978-62-1 |
5mg |
￥56200 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
I3159 |
≥98% (HPLC), solid
IMD-0354 ≥98% (HPLC), solid |
978-62-1 |
10mg |
￥101000 |
2024-03-01 |
購入 |
IMD-0354 化学特性,用途語,生産方法
使用
IMD-0354 has been used to study the effect of NF-κB (nuclear factor) inhibition on differentially expressed in chondrocytes 2. It has also been used to study the role of NF-κB signaling in tumor necrosis factor-induced certain transcription factors expression using human primary fibroblasts.
生物活性
Inhibitor of I κ B kinase-2 (IKK-2, IKK- β ) that blocks NF- κ B nuclear translocation. Attenuates myocardial ischemia/reperfusion injury by decreasing expression of adhesion molecules ICAM-1 and P-selectin and inhibiting cytokine and chemokine production in cardiomyocytes. Induces G 0 /G 1 cell cycle arrest and apoptosis in HMC-1? and breast cancer cells.
Biochem/physiol Actions
IMD-0354 acts as an inhibitor by inhibiting the phosphorylation of the NF-κB (nuclear factor) and its translocation into the nucleus. It blocks IκBα phosphorylation (IC50 ~ 250 nM). Cardioprotectant, that reduces IL-1β and MCP-1 production (IC50 < 1 μM) in cardiomyocytes. IMD-0354 affects angiogenesis, which has been observed in human umbilical vein endothelial cells. It prevents tube formation and migration of the cells. In vivo studies also prove that IMD-0354 inhibits retinal vessel growth. IMD-0354 also acts as an inhibitor of Aquaporin 4 (AQP4) inhibitor (IC50 0.2μM) with no inhibitory potency to IKK-β. [4]
IMD-0354 上流と下流の製品情報
原材料
準備製品
IMD-0354 生産企業
Global( 99)Suppliers
978-62-1()キーワード:
- 978-62-1
- Benzamide, N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-
- N-[3,5-Bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide IMD0354
- IKK-2 Inhibitor V - CAS 978-62-1 - Calbiochem
- IKK-2 INHIBITOR V; IMD 0354;IMD0354;
- IMD-0354, 99%, a synthetic selective NF-kB inhibitor
- IMD 0354;IMD-0354
- IMD-0354 USP/EP/BP
- IMD0354,IκB kinase,Inhibitor,I kappa B kinase,IKK,inhibit,IMD-0354