METHYL (1-TRIMETHYLSILYL)ACRYLATE 化学特性,用途語,生産方法
物理的性質
bp 75 °C/50 mmHg, 152 °C/690 mmHg.
使用
Methyl 2-Trimethylsilylacrylate is widely used as reactive, α-silyl Michael acceptor for conjugate addition of carbanions,
enolate anions, organolithium reagents, and Grignard
reagents; affords 3-cyclopentenecarboxylates and cyclohexanecarboxylates
by [3 + 2] and [4 + 2] annulation methods; provides
α-silyl esters and vinylsilanes by organolithium conjugate
additions.
製造方法
Methyl 2-Trimethylsilylacrylate is prepared by the reaction of (E)-2-
(trimethylsilyl)vinyllithium with methyl chloroformate or by
carbonation of the corresponding Grignard reagent prepared
from (1-bromovinyl)trimethylsilane, giving 2-trimethylsilylacrylic
acid. The methyl ester is prepared from the acid
by direct esterification with absolute methanol in the presence
of mineral acid, by reaction with diazomethane at low temperature,
or by treatment with BF3·MeOH complex.
METHYL (1-TRIMETHYLSILYL)ACRYLATE 上流と下流の製品情報
原材料
準備製品