コプロスタノール 化学特性,用途語,生産方法
解説
5β-cholestan-3β-ol．C27H48O(388.67)．コプロスタノール，食肉動物の糞中の主ステロール．コレステロールが腸内細菌で代謝されて生じたもの．融点101～102 ℃ の結晶．[α]D"＋28°(クロロホルム)．水に難溶．森北出版「化学辞典（第2版）
使用
Coprostan-3-ol is a 27-carbon stanol resulted from biohydrogenation of cholesterol in the gut of most higher animals. It is a common biomarker for the presence of human faecal matter in the environment (1,2).This compound is a contaminant of emerging concern (CECs).
一般的な説明
Coprostan-3-ol is a cholesterol derivative that can be prepared from 5β-cholestan-3-one via reduction.
純化方法
A possible impurity is the 3-ol from which it can be separated by chromatography on Al2O3 and eluting with Et2O/*C6H6 (1:24) whereby the 3-ol runs first (m 116-117o) and further elution gives the pure coprosterol (m 99-101o). Crystallise it from MeOH or aqueous EtOH. Its solubility is 0.79% in H2O at 25o. [Bridgewater & Shoppee J Chem Soc 1709 1953, Shoppee & Summers J Chem Soc 687 1950.]
コプロスタノール 上流と下流の製品情報
原材料
準備製品