ナルメフェン
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- CAS番号.
- 55096-26-9
- 化学名:
- ナルメフェン
- 别名:
- 4,5α-エポキシ-6-メチレン-17-(シクロプロピルメチル)モルフィナン-3,14-ジオール;ナルメフェン;ナルメトレン;17-(シクロプロピルメチル)-4,5α-エポキシ-6-メチレンモルフィナン-3,14-ジオール;4,5α-エポキシ-17-(シクロプロピルメチル)-6-メチレンモルフィナン-3,14-ジオール;(1S,5R,13S,17S)-4-(シクロプロピルメチル)-14-メチリデン-12-オキサ-4-アザペンタシクロ[9.6.1.01,13.05,17.07,18]オクタデカ-7,9,11(18)-トリエン-10,17-ジオール
- 英語名:
- Nalmefene
- 英語别名:
- C08027;NALMEFENE;ORF-11676;nalmetrene;Nalmefene d3;Nalmefene-D7;NalMefene USP;6-Deoxo-6-methylenenaltrexone;6-desoxy-6-methylenenaltrexone;4,5α-Epoxy-6-methylene-17-(cyclopropylmethyl)morphinan-3,14-diol
- CBNumber:
- CB1747788
- 化学式:
- C21H25NO3
- 分子量:
- 339.44
- MOL File:
- 55096-26-9.mol
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ナルメフェン 物理性質
- 融点 :
- 182-185?C
- 沸点 :
- 507.9±50.0 °C(Predicted)
- 比重(密度) :
- 1.38±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- クロロホルム（微量）、ジクロロメタン（微量）、DMSO（微量）、メタノール（Sl
- 外見 :
- 個体
- 酸解離定数(Pka):
- pKa 7.63(H2O) (Uncertain)
- 色:
- ホワイトからオフホワイト
- CAS データベース:
- 55096-26-9
- NISTの化学物質情報:
- Nalmefene(55096-26-9)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
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富士フイルム和光純薬株式会社(wako)
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W01TOC3971 |
Nalmefene - d3 |
55096-26-9 |
1mg |
￥81000 |
2018-12-26 |
購入 |
ナルメフェン 化学特性,用途語,生産方法
効能
抗酒癖薬, 麻薬拮抗薬, オピオイド受容体部分作動薬/拮抗薬
化学的特性
Off-White Solid
使用
A structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist.
生物学の機能
Nalmefene (Revex) is a long-acting injectable pure opioid
antagonist recently introduced in the United States.
It binds all opioid receptors and reverses the effects of
opioid agonists at those receptors.The onset of action is 2 minutes after IV administration. Hepatic metabolism
is slow and occurs via glucuronide conjugation to inactive
metabolites. Its half-life of 11 hours is about 5 times
that of naloxone. Indications include use in postoperative
settings to reverse respiratory depression and in
opioid overdose. Due to the long duration of action of
nalmefene, however, naloxone may be preferred for
treatment of overdose because it produces a shorter duration
of withdrawal effects.
一般的な説明
Nalmefene (Revex) is a pure opioid antagonist that is the6-methylene analog of naltrexone. It is available as a solutionfor IV, IM, or subcutaneous (SC) administration toreverse the effects of opioids after general anesthesia andin the treatment of overdose. It is longer acting than naloxonebut otherwise has a similar pharmacodynamic andmetabolic (3-glucuronidation) profile. Nalmefene hashigher oral bioavailability (approximately 40%) thannaloxone or naltrexone and is currently being investigatedas an oral treatment for pathological gambling and alcoholabuse.
ナルメフェン 上流と下流の製品情報
原材料
準備製品
ナルメフェン 生産企業
Global( 59)Suppliers
55096-26-9(ナルメフェン)キーワード:
- 55096-26-9
- [5ALPHA]-17-[CYCLOPROPYLMETHYL]-4,5-EPOXY-6-METHYLENEMORPHINAN-3,14-DIOL
- 17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol
- NALMEFENE
- (5alpha)-17-(cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinon-3,14-diol
- 6-desoxy-6-methylenenaltrexone
- nalmetrene
- (5α)-17-(cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol
- 6-Deoxo-6-methylenenaltrexone
- 9a-(Cyclopropylmethyl)-4,5alpha-epoxy-6-methylen-3,14-morphinandiol
- 17-(Cyclopropylmethyl)-4,5α-epoxy-6-methylenemorphinan-3,14-diol
- 4,5α-Epoxy-6-methylene-17-(cyclopropylmethyl)morphinan-3,14-diol
- C08027
- (5α)-17-(d3-Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol
- Nalmefene d3
- ORF-11676
- NalMefene USP
- Morphinan-3,14-diol,17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5a)-
- (4R,4aS,7aS,12bS)-3-(cyclopropylmethyl)-7-methylene-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,9-diol
- Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, (5α)-
- Nalmefene-d3Q: What is
Nalmefene-d3 Q: What is the CAS Number of
Nalmefene-d3
- Nalmefene-D7
- 4,5α-エポキシ-6-メチレン-17-(シクロプロピルメチル)モルフィナン-3,14-ジオール
- ナルメフェン
- ナルメトレン
- 17-(シクロプロピルメチル)-4,5α-エポキシ-6-メチレンモルフィナン-3,14-ジオール
- 4,5α-エポキシ-17-(シクロプロピルメチル)-6-メチレンモルフィナン-3,14-ジオール
- (1S,5R,13S,17S)-4-(シクロプロピルメチル)-14-メチリデン-12-オキサ-4-アザペンタシクロ[9.6.1.01,13.05,17.07,18]オクタデカ-7,9,11(18)-トリエン-10,17-ジオール