Nalmefene
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Nalmefene 속성
- 녹는점
- 182-185?C
- 끓는 점
- 507.9±50.0 °C(Predicted)
- 밀도
- 1.38±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름(약간 용해됨), 디클로로메탄(약간 용해됨), DMSO(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- pKa 7.63(H2O) (Uncertain)
- 색상
- 흰색에서 황백색까지
- CAS 데이터베이스
- 55096-26-9
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36 | ||
| WGK 독일 | 3 | ||
| 유해 물질 데이터 | 55096-26-9(Hazardous Substances Data) |
| 그림문자(GHS): |
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| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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Nalmefene C화학적 특성, 용도, 생산
화학적 성질
Off-White Solid용도
A structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist.Biological Functions
Nalmefene (Revex) is a long-acting injectable pure opioid antagonist recently introduced in the United States. It binds all opioid receptors and reverses the effects of opioid agonists at those receptors.The onset of action is 2 minutes after IV administration. Hepatic metabolism is slow and occurs via glucuronide conjugation to inactive metabolites. Its half-life of 11 hours is about 5 times that of naloxone. Indications include use in postoperative settings to reverse respiratory depression and in opioid overdose. Due to the long duration of action of nalmefene, however, naloxone may be preferred for treatment of overdose because it produces a shorter duration of withdrawal effects.일반 설명
Nalmefene (Revex) is a pure opioid antagonist that is the6-methylene analog of naltrexone. It is available as a solutionfor IV, IM, or subcutaneous (SC) administration toreverse the effects of opioids after general anesthesia andin the treatment of overdose. It is longer acting than naloxonebut otherwise has a similar pharmacodynamic andmetabolic (3-glucuronidation) profile. Nalmefene hashigher oral bioavailability (approximately 40%) thannaloxone or naltrexone and is currently being investigatedas an oral treatment for pathological gambling and alcoholabuse.Nalmefene 준비 용품 및 원자재
원자재
준비 용품
Nalmefene 공급 업체
글로벌( 59)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
| Alfa Chemistry | +1-5166625404 |
Info@alfa-chemistry.com | United States | 21317 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 |
shchemsky@sina.com | China | 32344 | 50 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 |
isunpharm@qq.com | China | 4428 | 55 |
| Shanghai Kewel Chemical Co., Ltd. | 021-64609169 18901607656 |
greensnown@163.com | China | 9911 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
| Chengdu Dianchun Technology Co., Ltd | 400-1166-196 18502815961 |
cdhxsj@163.com | China | 14623 | 60 |
| Amatek Scientific Co. Ltd. | 0512-56316828 |
info@amateksci.com | China | 28821 | 58 |
Nalmefene 관련 검색:
폴리(에피클로로히드린)
nalmefene hydrochloride,NALMEFENE HCL
NornalMefene
NalMefene IMpurity
2,2'-Bisnalmefene (Nalmefene Impurity),Nalmefene Impurity
1-AMINOMETHYL-1-CYCLOHEXANOL HYDROCHLORIDE
(S)-1,2,3,4-tetrahydro-5-methoxy-N-propyl-2-Naphthalenamine(Rotigotine)
oxilorphan
(R)-3-Hydroxypiperidine hydrocloride
(1S,2R)-(+)-TRANS-2-PHENYL-1-CYCLOHEXANOL
CYCLOHEXYLPHENYL ETHER
2-CYCLOHEXYLPHENOL
2-PHENYLCYCLOHEXANOL
Volazocine
N-Propylcyclopropanemethylamine
(+)-CYCLAZOCINE
EPOXY
1-dibutylaminopropan-2-ol