2-[4-ヒドロキシ-3-(2-プロペニル)フェニル]-4-(2-プロペニル)フェノール 化学特性,用途語,生産方法
外観
白色の結晶又は結晶性の粉末
溶解性
メタノールに溶ける。
説明
Magnolol is derived from the root bark and branch bark of magnolia or Magnolia
officinalis. Magnolia officinalis was first written in the《ben jing》, it prefers cool
and humid climate and well-drained acid soil. Cortex magnoliae officinalis (hou po)
is mainly produced in Sichuan (Wan quan, Shizhu, Guanxian), Hubei (Shien,Yichang,
Lichuan), Zhejiang (Longquan, Anhui), and other places. It is also distributed in
Fujian, Jiangxi, Hunan, Guangxi, Yunnan, Guizhou, Shanxi, Gansu, and other places.
Cortex magnoliae officinalis from Sichuan and Hubei is called “chuan pu,” with better
quality, while in Zhejiang, it is called “warm park,” with a larger output.
物理的性質
Appearance: white fine powder. Solubility: practically insoluble in water; very soluble
in benzene, ethyl ether, chloroform, and acetone. Melting point: magnolol is
102 °C. Honokiol is 87.5 °C.
来歴
In 1930, magnolol was first isolated from the bark of Cortex magnoliae officinalis
in China by Japanese Sugii, and it was also isolated from Cortex magnoliae officinalis
in Japan. In 1973, magnolol and its isomers honokiol were isolated from Cortex magnoliae officinalis in China and Japan by Japanese Fujita.
The drug research and development of magnolol and honokiol remain in pharmacological activity and preclinical research. Kyung Hee University from Korea declared a preclinical study in 2003, in which allergy, anxiety, angina, and heart failure are indications for honokiol.
使用
Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. Recent studies show that Honokiol displays antiangiogenic, antiinflammatory, and antitumor properties in preclinical models, w
ithout appreciable toxicity. Honokiol has been shown to inhibit the bone metastatic growth of human prostate cancer cells.
適応症
These compounds are recorded in the British Pharmacopoeia (2017) and European
Pharmacopoeia (8.7th ed.). They are mainly used as antibacterial and antifungal
agents.
一般的な説明
Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.
薬理学
Magnolol and honokiol have the pharmacological effects of prolonging central
muscle relaxation, inhibition of the central nervous, anti-inflammatory, antibacterial,
antimicrobial, antiulcer, antioxidant, antitumor, hormone regulation, and antidiabetes
.
2-[4-ヒドロキシ-3-(2-プロペニル)フェニル]-4-(2-プロペニル)フェノール 上流と下流の製品情報
原材料
2-Naphthalenemethanol, decahydro-8-[(2'-hydroxy-3,5'-di-2-propen-1-yl[1,1'-biphenyl]-4-yl)oxy]-α,α,4a,8-tetramethyl-, (2R,4aR,8R,8aR)-
準備製品