2-(3-シアノ-4-イソブトキシフェニル)-4-メチル-5-チアゾールカルボン酸エチル
2-(3-シアノ-4-イソブトキシフェニル)-4-メチル-5-チアゾールカルボン酸エチル 物理性質
- 融点 :
- 176 °C
- 沸点 :
- 497.1±55.0 °C(Predicted)
- 比重(密度) :
- 1.22
- 貯蔵温度 :
- Sealed in dry,Room Temperature
- 溶解性:
- DMSO（微量、加温）、メタノール（ごく微量、加温）
- 外見 :
- 個体
- 酸解離定数(Pka):
- 1.02±0.10(Predicted)
- 色:
- ホワイトからオフホワイト
- InChI:
- InChI=1S/C18H20N2O3S/c1-5-22-18(21)16-12(4)20-17(24-16)13-6-7-15(14(8-13)9-19)23-10-11(2)3/h6-8,11H,5,10H2,1-4H3
- InChIKey:
- OGAZOYHQFBSRMC-UHFFFAOYSA-N
- SMILES:
- S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(OCC(C)C)C(C#N)=C1
- CAS データベース:
- 160844-75-7(CAS DataBase Reference)
2-(3-シアノ-4-イソブトキシフェニル)-4-メチル-5-チアゾールカルボン酸エチル 価格
もっと(2)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
東京化成工業
|
E1414 |
>98.0%(HPLC)(N)
Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate >98.0%(HPLC)(N) |
160844-75-7 |
5G |
￥8300 |
2024-03-01 |
購入 |
|
東京化成工業
|
E1414 |
>98.0%(HPLC)(N)
Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate >98.0%(HPLC)(N) |
160844-75-7 |
25G |
￥29000 |
2024-03-01 |
購入 |
2-(3-シアノ-4-イソブトキシフェニル)-4-メチル-5-チアゾールカルボン酸エチル 化学特性,用途語,生産方法
外観
白色～ほとんど白色粉末～結晶
化学的特性
White crystalline powder
使用
Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
合成
CarboxylatePotassium carbonate (300 g, 2.17 mol) and isobutyl bromide (142.7 g, 1.041 mol) were added to a solution of ethyl-2-(3-cyano-4-hydroxyphenyl)-4-methyl-5-thiazole carboxylate (100 g, 0.347 mol) in dimethylformamide (300 mL), and the reaction mixture was heated at a temperature of about 75°C for about 8 hours. After completion of the reaction, the reaction mixture was cooled to about 40°C, and water was added. The reaction mixture was further cooled to about 0°C and stirred for about 1 hour. The solid thus obtained was filtered, washed with water, and dried to give Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate. (Yield: 11 lg, 92.9%)
2-(3-シアノ-4-イソブトキシフェニル)-4-メチル-5-チアゾールカルボン酸エチル 上流と下流の製品情報
原材料
準備製品
2-(3-シアノ-4-イソブトキシフェニル)-4-メチル-5-チアゾールカルボン酸エチル 生産企業
Global( 394)Suppliers
| 名前 |
電話番号 |
電子メール |
国籍 |
製品カタログ |
優位度 |
|
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.
|
+86-18616643091 +86-18616643091
|
info@rochipharma.com |
China |
246 |
58 |
|
Hebei Mojin Biotechnology Co., Ltd
|
+8613288715578
|
sales@hbmojin.com |
China |
12456 |
58 |
|
Hebei Yanxi Chemical Co., Ltd.
|
+8617531190177
|
peter@yan-xi.com |
China |
5993 |
58 |
|
Zibo Hangyu Biotechnology Development Co., Ltd
|
+86-0533-2185556 +8617865335152
|
Mandy@hangyubiotech.com |
China |
11013 |
58 |
|
Anhui Ruihan Technology Co., Ltd
|
+8617756083858
|
daisy@anhuiruihan.com |
China |
994 |
58 |
|
Capot Chemical Co.,Ltd.
|
571-85586718 +8613336195806
|
sales@capotchem.com |
China |
29797 |
60 |
|
Shanghai Daken Advanced Materials Co.,Ltd
|
+86-371-66670886
|
info@dakenam.com |
China |
15928 |
58 |
|
Beijing Cooperate Pharmaceutical Co.,Ltd
|
010-60279497
|
sales01@cooperate-pharm.com |
CHINA |
1811 |
55 |
|
Henan Tianfu Chemical Co.,Ltd.
|
+86-0371-55170693 +86-19937530512
|
info@tianfuchem.com |
China |
21691 |
55 |
|
Hangzhou FandaChem Co.,Ltd.
|
008657128800458; +8615858145714
|
fandachem@gmail.com |
China |
9348 |
55 |
160844-75-7(2-(3-シアノ-4-イソブトキシフェニル)-4-メチル-5-チアゾールカルボン酸エチル)キーワード:
- 160844-75-7
- 5-Thiazolecarboxylicacid, 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-, ethyl ester
- 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
- ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl
- Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
- Ethyl> 2-(3-cyano-4-isobutoxyphenyl)-4-Methyl-5-th
- 5-carboxylato-2-[3-cyano-4-(2-Methylpropoxy)phenyl]-1-ethyl-4-Methyl-1H-1$l^{4},3-thiazol-1-yl
- ethyl ester of febuxostat
- 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Me
- Febuxostat Ethyl Ester Impurity
- Febuxostat Impurity 15/Febuxostat Ethyl Ester/Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
- Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazol
- Febuxostat-7
- 2[3-Cyano-4-(2-methyl propoxy)phenyl]4-methyl-5-thiazole carboxylic acid ethyl ester (CPT)
- ethyl 2-(3-cyano-4-isobutoxyphenyl)
- Non-Bust Impurity 23
- 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester
- FEBUXOSTAT INT N-1
- 2-[3-CYANO-4-(2-METHYLPROPOXY)PHENYL]-4-METHYL-5-THIAZOLECARBOXYLIC ACID ETHYL
- Febuxostat intermediates，Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4- methyl-5-thiazolecarboxylate
- 2-(4-isobutoxyphenyl)-3-carboxylate)4-methyl-1,3- thiazole-5- carboxylate acid( Febuxostat dicarboxylic acid impurity)
- Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarbo...
- Febuxostat Impurities3
- 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl esterQ: What is
2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Q: What is the CAS Number of
2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Q: What is the storage condition of
2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester
- Febuxostat Ethyl Ester
- 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazolecarboxylic acid ethyl ester
- Ethyl 2-(3- cyano -4- isobutyloxyphenyl) -4- methylthiazole -5- carboxylate
- Ethyl 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylate
- Ethyl 2-(3-cyno-4-isobutoxyphenyl)-4-methyl-5-
thiazolecarboxylate
- 2-(4-ISOBUTOXYPHENYL)-3-CARBOXYLATE)4-METHYL-1,3- THIAZOLE-5-
- Febuxostat Ethyl Ester
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5- carboxylate
- 2-(3-シアノ-4-イソブトキシフェニル)-4-メチル-5-チアゾールカルボン酸エチル