ChemicalBook >> CAS DataBase List >>Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
- CAS No.
- 160844-75-7
- Chemical Name:
- Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
- Synonyms
- 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazolecarboxylic acid ethyl ester;Febuxostat Ethyl Ester;Febuxostat-7;FEBUXOSTAT INT N-1;Non-Bust Impurity 23;Febuxostat Impurities3;ethyl ester of febuxostat;Febuxostat Ethyl Ester Impurity;ethyl 2-(3-cyano-4-isobutoxyphenyl);2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Me
- CBNumber:
- CB22129451
- Molecular Formula:
- C18H20N2O3S
- Molecular Weight:
- 344.43
- MDL Number:
- MFCD09833701
- MOL File:
- 160844-75-7.mol
Last updated:2024-03-25 11:40:39
| Melting point | 176 °C |
|---|---|
| Boiling point | 497.1±55.0 °C(Predicted) |
| Density | 1.22 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Very Slightly, Heated) |
| form | Solid |
| pka | 1.02±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C18H20N2O3S/c1-5-22-18(21)16-12(4)20-17(24-16)13-6-7-15(14(8-13)9-19)23-10-11(2)3/h6-8,11H,5,10H2,1-4H3 |
| InChIKey | OGAZOYHQFBSRMC-UHFFFAOYSA-N |
| SMILES | S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(OCC(C)C)C(C#N)=C1 |
| CAS DataBase Reference | 160844-75-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| HS Code | 2934.10.2000 | |||||||||
| NFPA 704 |
|
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1414 | Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate | 160844-75-7 | 5G | $96 | 2024-03-01 | Buy |
| TCI Chemical | E1414 | Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate | 160844-75-7 | 25G | $286 | 2024-03-01 | Buy |
| TRC | E907780 | Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate | 160844-75-7 | 1g | $240 | 2021-12-16 | Buy |
| Ark Pharm | P000219188 | Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 97% | 160844-75-7 | 25g | $262 | 2021-12-16 | Buy |
| Matrix Scientific | 090804 | Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 95+% | 160844-75-7 | 25g | $390 | 2021-12-16 | Buy |
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Chemical Properties,Uses,Production
Chemical Properties
White crystalline powder
Uses
Ethyl 2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is an impurity of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
Synthesis
CarboxylatePotassium carbonate (300 g, 2.17 mol) and isobutyl bromide (142.7 g, 1.041 mol) were added to a solution of ethyl-2-(3-cyano-4-hydroxyphenyl)-4-methyl-5-thiazole carboxylate (100 g, 0.347 mol) in dimethylformamide (300 mL), and the reaction mixture was heated at a temperature of about 75°C for about 8 hours. After completion of the reaction, the reaction mixture was cooled to about 40°C, and water was added. The reaction mixture was further cooled to about 0°C and stirred for about 1 hour. The solid thus obtained was filtered, washed with water, and dried to give Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate. (Yield: 11 lg, 92.9%)
Synthesis of Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate from 1-Bromo-2-methylpropane and ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate Preparation Products And Raw materials
Raw materials
5-iodo-2-isobutoxybenzonitrile
ETHYL 2-(3-FORMYL-4-ISOBUTOXYPHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate
1of3
Preparation Products
Global( 395)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12452 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9353 | 55 |
View Lastest Price from Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-10 | Febuxostat Intermediates
160844-75-7
|
US $0.00 / Kg/Bag | 2Kg/Bag | 99% up, High Density | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-03-28 | Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
160844-75-7
|
US $0.00 / kg | 25kg | 98%-99% | Inquiry | PNP Biotech Co. Ltd | |
 |
2024-01-02 | Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
160844-75-7
|
US $60.00-600.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- Febuxostat Intermediates
160844-75-7
- US $0.00 / Kg/Bag
- 99% up, High Density
- Sinoway Industrial co., ltd.
-
- Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
160844-75-7
- US $0.00 / kg
- 98%-99%
- PNP Biotech Co. Ltd
-
- Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
160844-75-7
- US $60.00-600.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
160844-75-7(Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate)Related Search:
Memantine
Ethyl 2-(3-Cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate
ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate
Febuxostat Acyl-β-D-glucuronide
Febuxostat Descyano Impurity
isopropyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Febuxostat Impurity 6
2,2'-[4-(2-Methylpropoxy)-1,3-phenylene]bis[4-Methyl-5-thiazolecarboxylic Acid
2-[3-Carboxy-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-thiazolecarboxylic Acid
2-(3-cyano-4-propoxyphenyl)-4-methylthiazole-5-carboxylic acid
1of4
5-Thiazolecarboxylicacid, 2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-, ethyl ester
2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate
Ethyl> 2-(3-cyano-4-isobutoxyphenyl)-4-Methyl-5-th
5-carboxylato-2-[3-cyano-4-(2-Methylpropoxy)phenyl]-1-ethyl-4-Methyl-1H-1$l^{4},3-thiazol-1-yl
ethyl ester of febuxostat
2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Me
Febuxostat Ethyl Ester Impurity
Febuxostat Impurity 15/Febuxostat Ethyl Ester/Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazol
Febuxostat-7
2[3-Cyano-4-(2-methyl propoxy)phenyl]4-methyl-5-thiazole carboxylic acid ethyl ester (CPT)
ethyl 2-(3-cyano-4-isobutoxyphenyl)
Non-Bust Impurity 23
2-(3-Cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic Acid Ethyl Ester
FEBUXOSTAT INT N-1
2-[3-CYANO-4-(2-METHYLPROPOXY)PHENYL]-4-METHYL-5-THIAZOLECARBOXYLIC ACID ETHYL
Febuxostat intermediates，Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4- methyl-5-thiazolecarboxylate
2-(4-isobutoxyphenyl)-3-carboxylate)4-methyl-1,3- thiazole-5- carboxylate acid( Febuxostat dicarboxylic acid impurity)
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarbo...
Febuxostat Impurities3
2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl esterQ: What is
2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Q: What is the CAS Number of
2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester Q: What is the storage condition of
2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazol-5-carboxylic acid ethyl ester
Febuxostat Ethyl Ester
2-[3-cyano-4-(2-Methylpropoxy)phenyl]-4-Methyl-5-Thiazolecarboxylic acid ethyl ester
Ethyl 2-(3- cyano -4- isobutyloxyphenyl) -4- methylthiazole -5- carboxylate
Ethyl 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylate
Ethyl 2-(3-cyno-4-isobutoxyphenyl)-4-methyl-5-
thiazolecarboxylate
2-(4-ISOBUTOXYPHENYL)-3-CARBOXYLATE)4-METHYL-1,3- THIAZOLE-5-
Febuxostat Ethyl Ester
Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5- carboxylate
160844-75-7
161797-01-2
Febuxostat Intermediates
Febuxostat intermediate