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アベルメクチンB1

アベルメクチンB1 化学構造式
71751-41-2
CAS番号.
71751-41-2
化学名:
アベルメクチンB1
别名:
アバメクチン;アベルメクチンB1;アバメクチン標準品;アバメクチン STANDARD;アバメクチン Standard, 100 µg/mL in MeOH
英語化学名:
Abamectin
英語别名:
AVM;avid;mk936;Zephy;affirm;ACIMIC;SADDLE;zephyr;avidec;avomec
CBNumber:
CB2258634
化学式:
C49H74O14
分子量:
887.11
MOL File:
71751-41-2.mol

アベルメクチンB1 物理性質

融点 :
150-155°C
比旋光度 :
D +55.7 ±2° (c = 0.87 in CHCl3)
沸点 :
717.52°C (rough estimate)
比重(密度) :
1.16
蒸気圧:
<2 x 10-7 Pa
屈折率 :
1.6130 (estimate)
闪点 :
150 °C
貯蔵温度 :
2-8°C
溶解性:
Soluble in DMSO
外見 :
neat
水溶解度 :
0.007-0.01 mg l-1 (20 °C)
Merck :
13,2
InChIKey:
GVWIWZFXCGTSLL-MSTMYQEVSA-N
CAS データベース:
71751-41-2(CAS DataBase Reference)
EPAの化学物質情報:
Abamectin (71751-41-2)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T+,N
Rフレーズ  20-28-50
Sフレーズ  36/37/39-45-60-61
RIDADR  2588
WGK Germany  3
RTECS 番号 CL1203000
国連危険物分類  6.1(a)
容器等級  II
有毒物質データの 71751-41-2(Hazardous Substances Data)
毒性 LD50 (technical grade) orally in sesame oil in mouse, rat: 13.5, 10.0 mg/kg; dermally in rabbit: >2000 mg/kg; LD50 in mallard duck, bobwhite quail: 84.6, >2000 mg/kg; LC50 (96 hr) in rainbow trout, bluegill: 3.6, 9.6 mg/l; LC50 (48 hr) in Daphnia magna: 0.34 mg/l (Merck Technical Data Sheet)
毒劇物取締法 II
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H300 飲み込むと生命に危険 急性毒性、経口 1, 2 危険 P264, P270, P301+P310, P321, P330,P405, P501
H330 吸入すると生命に危険 急性毒性、吸入 1, 2 危険 P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H361 生殖能または胎児への悪影響のおそれの疑い 生殖毒性 2 警告 P201, P202, P281, P308+P313, P405,P501
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 P260, P264, P270, P314, P501
H400 水生生物に強い毒性 水生環境有害性、急性毒性 1 警告 P273, P391, P501
H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 P273, P391, P501
注意書き
P201 使用前に取扱説明書を入手すること。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P273 環境への放出を避けること。
P304+P340 吸入した場合:空気の新鮮な場所に移し、呼吸しやすい 姿勢で休息させること。
P320 特別な治療が緊急に必要である(このラベ ルの...を見よ)。
P330 口をすすぐこと。
P403+P233 換気の良い場所で保管すること。容器を密閉 しておくこと。
P405 施錠して保管すること。

アベルメクチンB1 価格 もっと(9)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSP-615N アバメクチン
Abamectin
71751-41-2 10mg ¥15500 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01ACSP-615S アバメクチン Standard
Abamectin Standard, 100 ug/mL in MeOH
71751-41-2 1mL ¥15500 2018-12-26 購入
関東化学株式会社(KANTO) 49803-12 アバメクチン標準品
Abamectin standard
71751-41-2 100mg ¥15000 2018-12-13 購入
Sigma-Aldrich Japan 31732 アバメクチン PESTANAL?, analytical standard
Abamectin PESTANAL?, analytical standard
71751-41-2 100mg ¥18600 2018-12-25 購入
林純薬工業株式会社 99052259 アバメクチン
Abamectin
71751-41-2 50mg ¥15000 2018-12-15 購入

アベルメクチンB1 MSDS


Affirm

アベルメクチンB1 化学特性,用途語,生産方法

外観

白色〜ほとんど白色, 結晶性粉末

溶解性

水7-10ug/L(20℃)トルエン350,アセトン100,イソプロパノール70,クロロホルム25,エタノール20,メタノール19.5,n-ブタノール10,シクロヘキサン6(g/l 21℃)アセトンにやや溶けやすく、水にほとんど溶けない。

農薬用途

動物薬、殺虫剤

使用上の注意

アルゴン封入

化学的特性

Off-White to Yellow Crystalline Solid

化学的特性

Abamectin is a colorless to yellowish crystalline powder. It is soluble in acetone, methanol, toluene, chloroform, and ethanol, but insoluble in water. It is stable, and incompatible with strong oxidizing agents. Abamectin is a mixture of Abamectins containing about 80% Abamectin B1a and 20% Abamectin B1b. These two components, B1a and B1b, have very similar biological and toxicological properties. The Abamectins are insecticidal/miticidal compounds derived from the soil bacterium Streptomyces avermitilis. Abamectin is used to control insect and mite pests of citrus, pear, and nut tree crops, and is used by homeown- ers to control fi re ants. It acts on the nervous system of insects, causing paralyzing effects. Abamectin is a general use pesticide (GUP). It is grouped as toxicity class IV, meaning practically non-toxic, requiring no precautionary statement on its label

Originator

Abamectin,Yellow River Enterprise Co. (a.k.a Yelori)

使用

Mixture of Abamectins, containing at least 80% of Abamectin B1a (C48H72O14) and not more than 20% of Abamectin B1b (C47H70O14). Used as acaricide, insecticide

使用

ectoparasiticide, CNS stimuant, mutagen

使用

Acaricide; insecticide.

定義

Any of a group of broad spectrum antiparasitic antibiotics produced by the actinomycete, Streptomyces avermitilis.

Manufacturing Process

1. The contents of a lyophilized tube of Streptomyces avermitilis MA-4680 is transferred aseptically to a 250 ml Erlenmeyer flask containing 305 ml of Medium 1: Dextrose 20 g, Peptone 5 g, Meat Extract 5 g, Primary Yeast 3 g, NaCl 5 g, CaCO3 (after pH adjustment) 3 g, Distilled water 1000 ml, pH 7.0. The inoculated flask is incubated for 3 days at 28°C on a rotary shaking machine at a speed of 220 RPM in a 2 inch radius circular orbit. At the end of this time, a 250 ml Erlenmeyer flask containing 50 ml of Medium 2 [Tomato Paste 20 g, Modified Starch (CPC) 20 g, Primary Yeast 10 g, CoCl2·6H2O 0.005 g, Distilled water 1000 ml, pH 7.2-7.4] is inoculated with a 2 ml sample from the first flask. This flask is incubated for 3 days at 28°C on a rotary shaking machine at a speed of 220 RPM in a 2 inch diameter circular orbit. 50 Ml of the resulting fermentation broth containing C-076 is effective against an N.dubius infection in mice.
2. A lyophilized tube of Streptomyces avermitilis MA-4680 is opened aseptically and the contents suspended in 50 ml of Medium 1 in a 250 ml Erlenmeyer flask. This flask is shaken for 3 days at 28°C on a rotary shaking machine 220 RPM with a 2 inch diameter circular orbit. A 0.2 ml portion of this seed medium is used to inoculate a Slant of Medium 3: Dextrose 10.0 g , Bacto Asparagine 0.5 g, K2HPO4 40.5 g, Bacto Agar 15.0 g , Distilled water 1000 ml, pH 7.0. The inoculated slant medium is incubated at 28°C for 10 days and stored at 4°C until used to inoculate 4 more slants of Medium 3. These slants are incubated in the dark for 8 days. One of these slants is used to inoculate 3 baffled 250 ml Erlenmeyer flasks containing 50 ml of No. 4 Seed Medium: Soluble Starch 10.0 g, Ardamine 5.0 g, NZ Amine E 5.0 g, Beef Extract 3.0 g, MgSO4·7H2O 0.5 g, Cerelose 1.0 g, Na2HPO4 0.190 g, KH2PO4 182 g, CaCO3 0.5 g, Distilled water 1000 ml, pH 7.0-7.2. The seed flasks are shaken for 2 days at 27-28°C on a rotary shaking machine at 220 RPM with a 2 inch diameter circular orbit. The contents of these flasks are pooled and used to inoculate (5% inoculum) baffled 250 ml Erlenmeyer flasks containing 40 ml of various production media. Flasks containing media 2, 5 and 6 are incubated for 4 days at 28°C on a rotary shaking machine at 220 RPM with a 2 inch diameter circular orbit. The resulting broth containing C-076 is then harvested and tested for anthelmintic activity. In all cases 6.2 ml of whole broth and the solids obtained from centrifuging 25 ml of whole broth are fully active against N.dubius helminth infections in mice.
3. The one of the four slants of Medium 3 prepared as in Example 2 is used to inoculate a baffled 250 ml Erlenmeyer flask containing 50 ml of Seed Medium No. 4. The seed flask is shaken for 1 day at 27- 28°C on a rotary shaking machine at 220 RPM with a 2 inch diameter circular orbit. The seed flask is then stored stationary at 4°C until it is ready to be used. The contents of this flask are then used to inoculate (5% inoculum) 20 unbaffled 250 ml Erlenmeyer flasks containing 40 ml of Medium No. 2. After 4 days incubation at 28°C on a rotary shaking machine at 220 RPM with a 2 inch diameter circular orbit, 19 of the flasks are harvested and pooled. The combined fermentation broths containing C-076 are filtered affording 500 ml of filtrate and 84 g of mycelia. 78 G of mycelia are extracted with 150 ml of acetone for ? hour with stirring and the mixture filtered. The filter cake is washed with 50 ml of acetone and the filtrate and washings are combined and concentrated to 46.5 ml 30 Ml of the concentrate is adjusted to pH 4 with dilute hydrochloric acid and extracted 3 times with 30 ml portions of chloroform. The extracts are dried by filtering through dry Infusorial Earth (Super-Cel) combined and concentrated to dryness in vacuum. The oily residue of C-076 weighing 91.4 mg is dissolved in chloroform sufficient to make 3 ml of solution which represents 1% of broth volume. The C-076 (Abamectin) obtained in this recovery procedure is fully active against N.dubius infections in mice. In addition, the chloroform extraction achieved a 70 fold purification of C-076 from the whole broth.

brand name

(Merck)Avomec [Veterinary] (Merial); Bovitin [Veterinary] (Merial); Doratect [Veterinary] (Merial); Duomectin [Veterinary] (Merial); Duotin [Veterinary] (Merial); Endecto (Merck); Enzec (Merck); Enzek (Merck); Parafoil (Merck); Vertimil (Zectin (Merck).

Therapeutic Function

Antiparasitic

一般的な説明

Odorless off-white to yellow crystals from methanol. Does not hydrolyze in water at pH 3, 5, 7. Used as an acaricide and insecticide.

反応プロフィール

A lactone.

危険性

A poison by ingestion. Moderately toxic by inhalation and skin contact.

健康ハザード

Abamectin is an insecticide and miticide. It is very toxic and causes adverse health effects if swallowed and/or inhaled. Emulsifi able concentrate formulations of Abamectin cause slight to moderate eye irritation and mild skin irritation. The symptoms of poisoning observed in laboratory animals include pupil dilation, vomiting, convulsions and/or trem- ors, and coma. Abamectin acts on insects by interfering with the nervous system. At very high doses, laboratory mammals develop symptoms of nervous system depression, inco- ordination, tremors, lethargy, excitation, and pupil dilation. Very high doses have caused death from respiratory failure in animals. Additionally, Abamectin has been reported to cause reproductive effects. Abamectin blocks the nerval conduct system in insects, caus- ing paralysis and death. Laboratory studies have indicated that abamectin may affect the nervous system in experimental animals. A 1-year study with dogs given oral doses of abamectin (0.5 and 1 mg/kg/day) caused adverse health effects, such as pupil dilation, weight loss, lethargy, tremors, and recumbency.

农业用途

Acaricide, Miticide, Insecticide, Anthelmentic: Used on fruit, vegetable and ornamental crops; pears, citrus fruits, and nut crops; to control mite and insect pests, and also to control household and lawn insects, including fire ants. Approved by the EPA for use in ash trees for control of emerald ash borer. A U.S. EPA restricted Use Pesticide (RUP).

製品名

ABACIDE®; AFFIRM®; AVID®, AVID-EC®; AVOMEC®; DYNAMEC®; INJECT-A- CIDE AV®; MK 936®(B 1A ); BOVITIN®; DORATECT®; DUOMECTIN®; DUOTIN®; ENDECTO®; ENZEC®; L 676,863® (B 1A ); MK 0936®; MK 936®; PARAFOIL®; VERTIMEC®, VERTIMIL®; VIVID®; ZECTIN®; ZEPHEYR®; ZEPHYR®

代謝経路

Abamectin contains the closely related avermectin B1a and B1b as the active ingredients. Avermectin B1a contains a sec-butyl moiety whereas avermectin B1b contains an isopropyl moiety. Chemical degradation and metabolism studies were conducted with avermectin B1a radiolabelled with 3H or 14C at various positions of this large molecule. The overall fates of avermectin B1a and B1b are similar since transformations at the butyl or propyl moiety were not observed.
Avermectin B1a is stable to hydrolytic degradation, but it is readily degraded to numerous products in aqueous solutions, soil, glass and plant foliage/fruit surfaces after light irradiation. Isomerisation and O-demethylation appear to the primary degradation reactions. In addition, hydroxylation is a major metabolic reaction in animals. Significant amounts of the residues in plants and animals were characterised as unidentified polar components.

Degradation

[3H]Avermectin B1a(1) was stable at 25 °C in pH 5,7 and 9 solutions up to 28 days. Less than 5% degradation was observed (PSD, 1992).
[14C]Avermectin B1a degraded rapidly in aqueous solution when exposed to sunlight with an observed DT50 of 3.5-12 hours. The △8,9 geometric isomer of avermectin B1a (2) was tentatively identified in aqueous solution (containing 2% acetone as photosensitiser) after irradiation under artificial light. Crouch et al. (1991) reported the photodegradation of avermectin B1a, as a thin film on glass surfaces under artificial light (>260 nm). At least 10 photodegradation products were characterised including the geometric isomers (2, 3), hydroxylated (4-7) and O-demethylated products (8) shown in Scheme 1.

予防処置

During use of Abamectin, occupational workers should use safety glasses, gloves, and protective clothing to prevent prolonged skin contact, and work in good ventilation.

アベルメクチンB1 上流と下流の製品情報

原材料

準備製品


アベルメクチンB1 生産企業

Global( 424)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21842 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile
+86-571-56059825 fandachem@gmail.com CHINA 3275 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2754 55
Hebei Chishuo Biotechnology Co., Ltd.
13292891350 +86 311 66567340
luna@speedgainpharma.com CHINA 1007 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897082
+86-531-58897093 ericqiao@jnchsd.com CHINA 158 58

71751-41-2(アベルメクチンB1)キーワード:


  • 71751-41-2
  • Mixture of abamectin B1a and B1b
  • Purity of AbaMectin
  • AverMectin B1a-AverMectin B1b Mixt.
  • ABAMECTIN 95%
  • Abamectin 100mg [71751-41-2]
  • AbaMectin (AverMectin B1)(FDA)
  • affirm
  • agri-mek
  • AGRI-MEK(R)
  • ACIMIC
  • ABACIDE
  • ABAMECTIN
  • ABAMECTINE
  • DYNAMEC
  • DYNAMEC(R)
  • BERMECTINE
  • AVERMECTIN B
  • AVERMECTIN B1
  • avid
  • AVERMECTIN B1, STREPTOMYCES AVERMITILIS
  • AVERMECTINE
  • AVERMECTIN
  • AVID(R)
  • AVM
  • MEDAMEC
  • SADDLE
  • mixture of avermectin b1a and avermectin b1b
  • TORPEDO
  • TRANSACT
  • VAPCOMIC
  • アバメクチン
  • アベルメクチンB1
  • アバメクチン標準品
  • アバメクチン STANDARD
  • アバメクチン Standard, 100 µg/mL in MeOH
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