シッカニン

シッカニン 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

シッカニン 化学特性,用途語,生産方法

解説

C22H30O3(342.47)．シッカニンは，病原真菌Helminthosporium siccans BH-34株の培養液から分離された抗真菌抗生物質．白色～淡黄色の結晶．融点138～142 ℃．[α]²⁰_D－136°(クロロホルム)．λmax 210，285 nm(エタノール)．pKa 10.9．水に不溶，有機溶媒に可溶．白癬(水虫)治療薬として使用される．LD50  ＞ 1000 mg/kg(ラット，経口)．森北出版「化学辞典（第2版）

効能

抗真菌薬

説明

Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC₅₀s = 0.87 and 9.3 μM for P. aeruginosa and rat mitochondria, respectively). It inhibits the growth of T. mentagrophytes (IC₅₀ = 0.3 μg/ml) via inhibition of succinate oxidation in the mitochondria. It also inhibits the growth of C. albicans strains with IC₅₀ values ranging from 5-40 and 80-90 μg/ml for aerobic and anaerobic conditions, respectively.

使用

Siccanin is an unusual, fused, phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.

Origin

Siccanin was found in the culture broth of Helminthosporium siccans by Sankyo Co. in 1962.

シッカニン 上流と下流の製品情報

原材料

準備製品

シッカニン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	3269	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29067	58
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	18521735133 18521732826;	market@aladdin-e.com	China	25015	65
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	17982	56
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58

22733-60-4(シッカニン)キーワード:

---

• 22733-60-4
• Siccanin
• 1,2,3,4,4a,5,6,6a,11b,13b-Decahydro-4,4,6a,9-tetramethyl-13H-benzo[a]furo[2,3,4-mn]xanthen-11-ol
• 13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 1,2,3,4,4a,5,6,6a,11b,13b-decahydro-4,4,6a,9-tetramethyl- (8CI)
• 13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 1,2,3,4,4a,5,6,6a,11b,13b-decahydro-4,4,6a,9-tetramethyl-, (4aS,6aS,11bR,13aS,13bS)- (9CI)
• 13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 1,2,3,4,4a,5,6,6a,11b,13b-decahydro-4,4,6a,9-tetramethyl-, [4aS-(4aa,6aa,11ba,13aR*,13ba)]-
• NSC 135048
• (13As)-1,2,3,4,4abeta,5,6,6A,11bbeta,13bbeta-decahydro-4,4,6abeta,9-tetramethyl-13H-benzo(A)furo(2,3,4-mn)xanthen-11-ol
• 13H-Benzo(A)furo(2,3,4-mn)xanthen-11-ol, 1,2,3,4,4A,5,6,6A,11B,13B-decahydro-4,4,6A,9-tetramethyl-, (4as-(4aalpha,6aalpha,11balpha,13ar*,13balpha))-
• Sicanina
• Sicanina [inn-spanish]
• Siccanine
• Siccanine [inn-french]
• Siccaninum
• CS 280, SI 23548
• 1H,11bH,13H-Benzo[a]furo[2,3,4-mn]xanthen-11-ol, 2,3,4,4a,5,6,6a,13b-octahydro-4,4,6a,9-tetramethyl-, (4aS,6aS,11bR,13aS,13bS)-
• Siccanin USP/EP/BP
• シッカニン
• シッカニン (JAN)
• (1S,4R,12S,15S,20S)-8,12,16,16-テトラメチル-3,11-ジオキサペンタシクロ[10.7.1.01,15.04,20.05,10]イコサ-5,7,9-トリエン-6-オール
• (13aS)-1,2,3,4,4aβ,5,6,6a,11bβ,13bβ-デカヒドロ-4,4,6aβ,9-テトラメチルベンゾ[a]フロ[2,3,4-mn]キサンテン-11-オール
• (4aS,13aS)-4,4,6aβ,9-テトラメチル-1,2,3,4,4aβ,5,6,6a,11bβ,13bβ-デカヒドロベンゾ[a]フロ[2,3,4-mn]キサンテン-11-オール
• (4aS,13aS)-1,2,3,4,4aβ,5,6,6a,11bβ,13bβ-デカヒドロ-4,4,6aβ,9-テトラメチルベンゾ[a]フロ[2,3,4-mn]キサンテン-11-オール
• (-)-シッカニン
• タックル