エリブリンメシル酸塩

エリブリンメシル酸塩 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

エリブリンメシル酸塩 化学特性,用途語,生産方法

効能

抗悪性腫瘍薬, 微小管重合阻害薬

商品名

ハラヴェン (エーザイ)

使用

Eribulin Mesylate is a synthetic analog of the marine natural product halichondrin B.

定義

ChEBI: Eribulin mesylate is a methanesulfonate salt obtained by reaction of eribulin with one equivalent of methanesulfonic acid. A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage. It has a role as an antineoplastic agent and a microtubule-destabilising agent. It contains an eribulin(1+).

臨床応用

Eribulin mesylate, a nontaxane, completely synthetic microtubule inhibitor, has recently been approved by the U.S. Food and Drug Administration as third-line treatment of metastatic breast cancer refractory to anthracyclines and taxanes.

臨床応用

Eribulin is a highly potent cytotoxic agent approved in the U.S. for the treatment of metastatic breast cancer for patients who have received at least two previous chemotherapeutic regimens. Eribulin was discovered and developed by Eisai and it is currently undergoing clinical evaluation for the treatment of sarcoma (PhIII) and non-small cell lung cancer which shows progression after platinumbased chemotherapy and for the treatment of prostate cancer (PhII). Early stage clinical trials are also underway to evaluate eribulin’s efficacy against a number of additional cancers. Eribulin is a structural analog of the marine natural product halichondrin B. Its mechanism of action involves the disruption of mitotic spindle formation and inhibition of tubulin polymerization which results in the induction of cell cycle blockade in the G2/M phase and apoptosis.

副作用

Eribulin Mesylate (Halaven) may cause serious side effects including:hives; difficulty breathing; swelling of your face, lips, tongue, or throat; chest pain; severe dizziness; fast or pounding heartbeats, numbness, tingling, or burning pain in your hands or feet; pain or burning when you urinate; confusion; uneven heart rate; extreme thirst; increased urination; leg discomfort; muscle weakness; limp feeling; fever; chill; painful mouth sores; pain when swallowing; cough; trouble breathing; pale skin; easy bruising; sore throat; skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Mode of action

Eribulin Mesylate is the mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.

エリブリンメシル酸塩 上流と下流の製品情報

原材料

準備製品

エリブリンメシル酸塩 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
ChemExpress	+86-021-58950125	info@chemexpress.com	China	555	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 15319487004	1015@dideu.com	China	2263	58

441045-17-6(エリブリンメシル酸塩)キーワード:

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• 441045-17-6
• Eribulin Mesylate
• Eribulin mesylate Halaven
• ER-086526 mesylate
• B1939 mesylate
• E7389 mesylate
• EribulinMesylate USP/EP/BP
• Eribulin Mesylate (E7389)
• Halaven
• Eribulin Mesilate
• Ibrine mesylate
• Ezebrine mesylate
• ER 086526,E-7389,Eribulin,metastatic,B1939,Inhibitor,Eribulin mesylate,inhibit,breast,Microtubule/Tubulin,cancer,Apoptosis,E7389,B 1939,B-1939,microtubule,E 7389,ER-086526,ER086526
• Irebulin mesylate
• Eribulin Mesylate iMpurity
• エリブリンメシル酸塩
• エリブリンメシル酸塩 (JAN)
• ハラヴェン
• (1S,3R,6R,9S,12S,14R,16R,18S,20R,21S,22S,26R,29S,31S,32R,33S,36R)-20-[(2R)-3-アミノ-2-ヒドロキシプロピル]-8,16,21-トリメトキシ-14-メチル-2,19,30,34,37,39,40,41-オクタオキサノナシクロ[24.9.2.13,32.13,33.16,9.112,16.018,22.029,36.031,35]ヘンテトラコンタン-24-オン
• (1R,4R,7S,10S,12R,14R,16S,18R,19S,20S,24R,27S,29S,30R,31S,34S,35R)-18-[(R)-2-ヒドロキシ-3-アミノプロピル]-31,29,34-(オキシメタントリイル)-6,14,19-トリメトキシ-12-メチル-17,28,33,36,37,38,39-ヘプタオキサヘプタシクロ[22.8.4.11,30.14,7.110,14.016,20.027,35]ノナトリアコンタン-22-オン