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4-ピコリン

4-ピコリン 化学構造式
108-89-4
CAS番号.
108-89-4
化学名:
4-ピコリン
别名:
4-ピコリン;4-メチルピリジン;γ-ピコリン;γピコリン;4メチルピリジン;4-ピコリン(γ-〃);Γ‐ピコリン;Γ-ピコリン(4-)
英語化学名:
4-Methylpyridine
英語别名:
GAMMAP;ba35846;Ba 35846;γ-Picoline;picoline-4;p-Picoline;4-PICOLINE;g-picoline;sigma-Picoline;GAMMA-PICOLINE
CBNumber:
CB3778430
化学式:
C6H7N
分子量:
93.13
MOL File:
108-89-4.mol

4-ピコリン 物理性質

融点 :
2.4 °C(lit.)
沸点 :
145 °C(lit.)
比重(密度) :
0.957 g/mL at 25 °C(lit.)
蒸気密度:
3.2 (vs air)
蒸気圧:
4 mm Hg ( 20 °C)
屈折率 :
n20/D 1.504(lit.)
闪点 :
134 °F
貯蔵温度 :
Flammables area
溶解性:
alcohol: soluble(lit.)
酸解離定数(Pka):
6.02(at 20℃)
外見 :
Liquid
色:
Clear light yellow
爆発限界(explosive limit):
1.3-8.7%(V)
水溶解度 :
soluble
Sensitive :
Air Sensitive & Hygroscopic
Merck :
14,7402
BRN :
104586
InChIKey:
FKNQCJSGGFJEIZ-UHFFFAOYSA-N
CAS データベース:
108-89-4(CAS DataBase Reference)
NISTの化学物質情報:
Pyridine, 4-methyl-(108-89-4)
EPAの化学物質情報:
Pyridine, 4-methyl-(108-89-4)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T
Rフレーズ  10-20/22-24-36/37/38
Sフレーズ  26-36-45
RIDADR  UN 1992 3/PG 3
WGK Germany  1
RTECS 番号 UT5425000
自然発火温度 1000 °F
TSCA  Yes
国連危険物分類  3
容器等級  III
HSコード  29333955
有毒物質データの 108-89-4(Hazardous Substances Data)
毒性 LD50 orally in rats: 1.29 g/kg (Smyth)
消防法 危-4-2-III
化審法 (5)-711
絵表示(GHS)
注意喚起語 Danger
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H226 引火性の液体および蒸気 引火性液体 3 警告
H302 飲み込むと有害 急性毒性、経口 4 警告 P264, P270, P301+P312, P330, P501
H311 皮膚に接触すると有毒 急性毒性、経皮 3 危険 P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 P264, P280, P302+P352, P321,P332+P313, P362
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
H332 吸入すると有害 急性毒性、吸入 4 警告 P261, P271, P304+P340, P312
H335 呼吸器への刺激のおそれ 特定標的臓器毒性、単回暴露; 気道刺激性 3 警告
注意書き
P210 熱/火花/裸火/高温のもののような着火源から遠ざ けること。-禁煙。
P261 粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P303+P361+P353 皮膚(または髪)に付着した場合:直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P312 気分が悪い時は医師に連絡すること。
P405 施錠して保管すること。

4-ピコリン 価格 もっと(18)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01COBQE-4848 4-メチルピリジン
4-Methylpyridine
108-89-4 5g ¥3600 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01COBQE-4848 4-メチルピリジン
4-Methylpyridine
108-89-4 25g ¥5400 2018-12-26 購入
東京化成工業 P0417 4-メチルピリジン >98.0%(GC)(T)
4-Methylpyridine >98.0%(GC)(T)
108-89-4 500mL ¥4600 2018-12-04 購入
東京化成工業 P0417 4-メチルピリジン >98.0%(GC)(T)
4-Methylpyridine >98.0%(GC)(T)
108-89-4 25mL ¥1800 2018-12-04 購入
関東化学株式会社(KANTO) 32224-30 γ‐ピコリン >98.0%(GC)
γ‐Picoline (γ=4) >98.0%(GC)
108-89-4 25mL ¥1800 2018-12-13 購入

4-ピコリン MSDS


sigma-Picoline

4-ピコリン 化学特性,用途語,生産方法

外観

無色~暗褐色, 澄明の液体

溶解性

水、エタノール及びアセトンに極めて溶けやすい。水、エタノール及びエーテルに可溶。

用途

溶媒、ニコチン酸の製造、 医薬品(イソニコチン酸ヒドラジド)、界面活性剤などの合成原料、溶剤、防水剤などの製造

用途

イソニコチン酸製造原料、医薬、樹脂、染料、加硫促進剤、溶剤などとして用いられる。

使用上の注意

不活性ガス封入

化学的特性

Clear light yellow liquid

化学的特性

Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers.

天然物の起源

4-Methylpyridine is released by energy-related processes. It is present in coal gassification wastewater (Pellizzari et al 1979), the environment of coke ovens (Naizer and Mashek 1974) and in waters from shale oil waste production (Dobson et al 1985; Hawthorne et al 1985; Leenheer et al 1982). It is also present in coal tar (HSDB, 1988), cigarette smoke (Brunneman et al 1978; IARC 1976) and pyroligneous liquids from woods (Yasuhara and Sugiwara 1987). Methods for the biological treatment of wastewaters containing 4-methylpyridine have been developed (Roubickova 1986) and its movement through (Leenheer and Stuber 1981) and degradation (Sims and Somners 1985) in soils examined.

使用

manufacture of isonicotinic acid and derivatives. In waterproofing agents for fabrics. As solvent for resins.

定義

ChEBI: A methylpyridine in which the methyl substituent is at position 4.

調製方法

Currently, 4-methylpyridine is produced by vapor-phase condensation of acetaldehyde and ammonia (3:1) with subsequent isolation of 4-methylpyridine from the reaction mixture. Reactants are exposed to dehydration-dehydrogenation catalysis such as lead oxide, copper oxide on alumina, thorium oxide, zinc oxide or cadmium oxide on silica-alumina, or cadmium fluoride on silica-magnesia at 400-500°C. This results in a 60% yield of 4-methylpyridine which is isolated by fractional distillation (USEPA 1982). Another production method involves the isolation from by-products of coking operations. The crude pyridine extracts come from noncondensable and condensable coke-oven gasses that have been dehydrated and separated by fractional distillation, but only 45% of 4-methylpyridine is obtained (USEPA 1982). 4-Methylpyridine also can be isolated from a dry distillation of bones or coal (Hawley 1977).

一般的な説明

Colorless moderately volatile liquid.

空気と水の反応

Highly flammable.

反応プロフィール

4-Methylpyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

健康ハザード

ACUTE/CHRONIC HAZARDS: Moderate fire risk.

健康ハザード

Data indicates that 4-methylpyridine is moderately toxic when administered orally and very toxic when given dermally and intraperitoneally (Smith 1982). Symptoms include occasional diarrhea, weight loss, anemia, and occular and facial paralysis.

火災危険

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

工業用途

4-Methylpyridine is used as a water-proofing agent for fabrics; as solvents for resins; in the synthesis of pharmaceuticals, dyestuffs, rubber accelerators, pesticides and laboratory reagent; as a catalyst; and as a curing agent (Hawley 1977; Windholz et al 1983). It is used for the synthesis of pharmaceuticals, especially isoniazid (USEPA 1982) and also for the production of 4-vinylpyridine to improve dyeability (USEPA 1982).

安全性プロファイル

Poison by ingestion and intraperitoneal routes. Moderately toxic by sktn contact. Mildly toxic by inhalation. A severe skin and eye irritant. Flammable liquid when exposed to heat, flames, oxidizers. To fight fire, use alcohol foam. When heated to decomposition it emits toxic fumes of NOx.

職業ばく露

(o-isomer); Suspected reprotoxic hazard, Primary irritant (w/o allergic reaction), (m-isomer): Possible risk of forming tumors, Primary irritant (w/o allergic reaction). Picolines are used as intermediates in pharmaceutical manufacture, pesticide manufacture; and in the manufacture of dyes and rubber chemicals. It is also used as a solvent.

応急処置

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

代謝

Pyridine and its alkyl derivatives are absorbed from the gastrointestinal tract, intraperitoneal cavity and lungs, with the peritoneal route being slightly more rapid and complete than gastrointestinal absorption. The methylpyridines also are rapidly absorbed through the skin (Reinhardt and BrittelH 1971).
The addition of a methyl group onto the pyridine molecule increases the rate of absorption of the resultant methylpyridines into the liver, kidneys, and brains of rats (Zharikov et al 1983). It was found that 4-picoline has a shorter residence time than the other substituted picolines in the liver, brain and kidney. Elimination occurred via a biphasic process.
Although the exact mechanism has not been determined, it appears that all methylpyridines are oxidized to their respective aromatic acids (Williams 1959). For example, the administration of 2-methylpyridine (0.5 to 1.0 g) to rabbits resulted in the excretion of unchanged parent compound along with α-picolinic acid.
Formation of an N-oxide also occurs with 4-methylpyridine (Gorrod and Damani 1980).

輸送方法

UN2313 Picolines, Hazard Class: 3; Labels: 3-Flammable liquid.

純化方法

It can be purified as for 2-methylpyridine. Biddescombe and Handley's method (above) for 3-methylpyridine is also applicable. Lidstone [J Chem Soc 242 1940] purified it via the oxalate (m 137-138o) by heating 100mL of 4-methylpyridine to 80o and adding slowly110g of anhydrous oxalic acid, followed by 150mL of boiling EtOH. After cooling and filtering, the precipitate is washed with a little EtOH, then recrystallised from EtOH, dissolved in the minimum quantity of water and distilled with excess 50% KOH. The distillate is dried with solid KOH and again distilled. Hydrocarbons can be removed from 4-methylpyridine by converting the latter to its hydrochloride, crystallising from EtOH/diethyl ether, regenerating the free base by adding alkali and distilling. As a final purification step, 4-methylpyridine can be fractionally crystallised by partial freezing to effect a separation from 3-methylpyridine. Contamination with 2,6-lutidine is detected by its strong absorption at 270nm. The hydrochloride has m 161o, and the picrate has m 167o(from Me2CO, EtOH or H2O). [Beilstein 20 III/IV 2732, 20/5 V 543.]

不和合性

Vapors may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Attacks copper and its alloys.

4-ピコリン 上流と下流の製品情報

原材料

準備製品


4-ピコリン 生産企業

Global( 223)Suppliers
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108-89-4(4-ピコリン)キーワード:


  • 108-89-4
  • 4-methyl-pyridin
  • Ba 35846
  • ba35846
  • gamma-Methylpyridine
  • para-Methylpyridine
  • 4-Picoline,4-Methylpyridine
  • 4-Picoline, 99% 250ML
  • 4-METHYLPYRIDINE FOR SYNTHESIS
  • 4-Picoline, 98.5%
  • 4-Picoline, 98.5%, 98.5%
  • sigma-Picoline
  • γ-Picoline
  • picoline-4
  • p-Methylpyridine
  • p-Picoline
  • Pyridine,4-methyl-
  • 4-PICOLINE
  • 4-METHYLPYRIDINE
  • GAMMA-PICOLINE
  • GAMMAP
  • g-picoline
  • 4-picoline (gamma)
  • PicolineMethylpyridine
  • 4-Methylpyrdine
  • 4-METHYL PYRIDINE (Picoline)
  • 4-Picoline, 99+%
  • 4-PICOLINE 98%
  • 4-methylpyridine 4-picoline
  • 4-Picoline, 99+% pure
  • 4-ピコリン
  • 4-メチルピリジン
  • γ-ピコリン
  • γピコリン
  • 4メチルピリジン
  • 4-ピコリン(γ-〃)
  • Γ‐ピコリン
  • Γ-ピコリン(4-)
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