1-[ビス(4-クロロフェニル)メチル]-3-[2-(2,4-ジクロロフェニル)-2-[(2,4-ジクロロフェニル)メトキシ]エチル]-1H-イミダゾール-3-イウム·クロリド

1-[ビス(4-クロロフェニル)メチル]-3-[2-(2,4-ジクロロフェニル)-2-[(2,4-ジクロロフェニル)メトキシ]エチル]-1H-イミダゾール-3-イウム·クロリド 価格 もっと(8)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01TOC2561	Calmidazolium chloride	57265-65-3	10mg	￥56000	2024-03-01	購入
Sigma-Aldrich Japan	C2313	コンパウンド48/80 Compound 48/80	57265-65-3	100mg	￥23000	2024-03-01	購入
Sigma-Aldrich Japan	C2313	コンパウンド48/80 Compound 48/80	57265-65-3	250mg	￥39600	2024-03-01	購入
Sigma-Aldrich Japan	C3930	カルミダゾリウムクロリド solid Calmidazolium chloride solid	57265-65-3	5mg	￥38100	2024-03-01	購入
Sigma-Aldrich Japan	C3930	カルミダゾリウムクロリド solid Calmidazolium chloride solid	57265-65-3	25mg	￥109000	2024-03-01	購入

1-[ビス(4-クロロフェニル)メチル]-3-[2-(2,4-ジクロロフェニル)-2-[(2,4-ジクロロフェニル)メトキシ]エチル]-1H-イミダゾール-3-イウム·クロリド 化学特性,用途語,生産方法

化学的特性

white to off-white powder

使用

Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+?transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+?influx distinct from store-operated Ca2+?entry and unaccompanied by Ca2+?store depletion, mobilizing stores and evoking a Ca2+?signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.

一般的な説明

Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.

生物活性

Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca 2+ -transporting ATPase with IC 50 values of 0.15 and 0.35 μ M respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.

1-[ビス(4-クロロフェニル)メチル]-3-[2-(2,4-ジクロロフェニル)-2-[(2,4-ジクロロフェニル)メトキシ]エチル]-1H-イミダゾール-3-イウム·クロリド 上流と下流の製品情報

原材料

準備製品

1-[ビス(4-クロロフェニル)メチル]-3-[2-(2,4-ジクロロフェニル)-2-[(2,4-ジクロロフェニル)メトキシ]エチル]-1H-イミダゾール-3-イウム·クロリド 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006608290; 18621169109	market03@meryer.com	China	40241	62
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 18521732826;	market@aladdin-e.com	China	25015	65
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60

57265-65-3(1-[ビス(4-クロロフェニル)メチル]-3-[2-(2,4-ジクロロフェニル)-2-[(2,4-ジクロロフェニル)メトキシ]エチル]-1H-イミダゾール-3-イウム·クロリド)キーワード:

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• 57265-65-3
• CALMODULIN INHIBITOR R 24571
• CALMIDAZOLIUM
• CALMIDAZOLIUM CHLORIDE
• COMPOUND R24571
• COMPOUND 48/80
• COMPOUND 48/80 TRIHYDROCHLORIDE
• R 24571
• R 24571 CHLORIDE
• 1-[bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride
• R 24571, 1-[bis(4-Chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-(2,4-dichlorobenzyloxy)ethyl]-1H-imidazolium chloride, 1-[Bis(4-chlorophenyl)methyl]-3-[2,4-dichloro-β-(2,4-dichlorobenzyloxy)phenethyl]imidazolium chloride
• 1-[BIS(P-CHLOROPHENYL)METHYL]-3-[2-(2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY)PHENETHYL)]IMIDAZOLIUM CHLORIDE
• 1-[BIS(P-CHLOROPHENYL)METHYL]-3-[2,4-DICHLORO-BETA-(2,4 DICHLOROBENZYLOXY) PHENETHYL]-IMIDAZOLIUM CHLORIDE
• [1-BIS-P-CHLOROPHENYL) METHYL]-3-[2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY) PHENYL]-IMIDAZOLIUM CHLORIDE
• 1-[BIS-(4-CHLOROPHENYL)METHYL]-3-[2-(2,4-DICHLOROPHENYL)-2-[(2,4-DICHLOROPHENYL)METHOXY]-ETHYL]-1H-IMIDAZOLIUM CHLORIDE
• 1-[BIS(4-CHLOROPHENYL)METHYL]-3-[2,4-DICHLORO-BETA-(2,4-DICHLOROBENZYLOXY)PHENETHYL]IMIDAZOLIUM CHLORIDE
• Calimidazoline
• Calmidazolium chloride,99%
• Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem
• Calmidazolium chloride (R 24571)
• Calmidazolium chloride (Synonyms: R 24571)
• 1-[bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichloroph enyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-im idazol-3-ium chloride
• Calmidazolium chlori
• 1-(Bis(4-chlorophenyl)methyl)-3-(2-((2,4-dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazol-3-ium chloride
• CaMK,Calmidazolium,Inhibitor,R24571,Calmidazolium chloride,inhibit,R-24571,Calmodulin-dependent protein kinases,Calmodulin-dependent kinases,Autophagy
• カルミダゾリウムクロリド
• カリミダゾリン
• 1-[ビス(4-クロロフェニル)メチル]-3-[2-(2,4-ジクロロフェニル)-2-[(2,4-ジクロロフェニル)メトキシ]エチル]-1H-イミダゾール-3-イウム·クロリド
• 塩化カルミダゾリウム
• 1-[ビス(4-クロロフェニル)メチル]-3-[2-(2,4-ジクロロフェニル)-2-[(2,4-ジクロロフェニル)メトキシ]エチル]-1H-イミダゾール-3-イウム・クロリド
• R-24571