CALMIDAZOLIUM CHLORIDE
- CAS No.
- 57265-65-3
- Chemical Name:
- CALMIDAZOLIUM CHLORIDE
- Synonyms
- R 24571;CALMIDAZOLIUM;COMPOUND 48/80;Calimidazoline;COMPOUND R24571;R 24571 CHLORIDE;Calmidazolium chlori;CALMIDAZOLIUM CHLORIDE;Calmidazolium chloride,99%;CALMODULIN INHIBITOR R 24571
- CBNumber:
- CB4231628
- Molecular Formula:
- C31H23Cl7N2O
- Molecular Weight:
- 687.69
- MDL Number:
- MFCD00077679
- MOL File:
- 57265-65-3.mol
Melting point | 172-176 °C |
---|---|
storage temp. | 2-8°C |
solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
form | solid |
color | white |
Water Solubility | Soluble in dimethyl sulfoxide, ethanol. methanol, chloroform, and propylene glycol. Insoluble in water. |
BRN | 6470244 |
FDA UNII | 8CQN259H2W |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301+H311+H331 | |||||||||
Precautionary statements | P261-P280-P301+P310+P330-P302+P352+P312-P304+P340+P312-P403+P233 | |||||||||
Safety Statements | 22-24/25 | |||||||||
RIDADR | UN 2811 6.1 / PGII | |||||||||
WGK Germany | 3 | |||||||||
RTECS | Gk2402500 | |||||||||
F | 3-8-10 | |||||||||
HS Code | 29332990 | |||||||||
NFPA 704 |
|
CALMIDAZOLIUM CHLORIDE price More Price(24)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C3930 | Calmidazolium chloride solid | 57265-65-3 | 5mg | $228 | 2024-03-01 | Buy |
Sigma-Aldrich | C2313 | Compound 48/80 | 57265-65-3 | 100MG | $132 | 2024-03-01 | Buy |
Sigma-Aldrich | C2313 | Compound 48/80 | 57265-65-3 | 250MG | $220 | 2024-03-01 | Buy |
Sigma-Aldrich | C2313 | Compound 48/80 | 57265-65-3 | 1G | $661 | 2024-03-01 | Buy |
Sigma-Aldrich | 208665 | Calmidazolium Chloride A cell-permeable calmodulin antagonist. | 57265-65-3 | 10mg | $167 | 2023-01-07 | Buy |
CALMIDAZOLIUM CHLORIDE Chemical Properties,Uses,Production
Chemical Properties
white to off-white powder
Uses
Calmidazolium chloride is a small molecule CaM antagonist and calcium channel protein inhibitor. Calmidazolium chloride demonstrates noncompetitive inhibition of platelet and sarcoplasmic reticulum Ca2+-ATPase activity and shows inhibition of Ca2+?transport activity in platelet microsomes. In HeLa cells, calmidazolium chloride stimulates a mechanism of cellular Ca2+?influx distinct from store-operated Ca2+?entry and unaccompanied by Ca2+?store depletion, mobilizing stores and evoking a Ca2+?signal through activation of phospholipase C. Calmidazolium chloride is described to inhibit constitutive nitric oxide synthase (NOS) activity without affecting inducible NOS in rat aorta. The dependence upon calmodulin of neuronal NOS (nNOS) in neuroblastoma N1E-115 cells was probed with calmidazolium chloride, where it was demonstrated to increase cGMP levels indirectly indicating an increase in NO output by nNOS. Calmidazolium chloride is also described to inhibit the activity of calmodulin N-methyltransferase.
General Description
Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.
Biological Activity
Calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca 2+ -transporting ATPase with IC 50 values of 0.15 and 0.35 μ M respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.
Biochem/physiol Actions
Inhibitor of calmodulin-regulated enzymes. It is also believed to directly block calcium channels in smooth muscle cells.
storage
+4°C
CALMIDAZOLIUM CHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
CALMIDAZOLIUM CHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34571 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94658 | 76 |
Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 | market03@meryer.com | China | 40240 | 62 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25009 | 65 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
57265-65-3(CALMIDAZOLIUM CHLORIDE)Related Search:
1of4