3-[2-[4-ビス(4-フルオロフェニル)メチレンピペリジノ]エチル]-2,3-ジヒドロ-2-チオキソキナゾリン-4(1H)-オン
3-[2-[4-ビス(4-フルオロフェニル)メチレンピペリジノ]エチル]-2,3-ジヒドロ-2-チオキソキナゾリン-4(1H)-オン 物理性質
- 融点 :
- 228-230 °C
- 沸点 :
- 637.1±65.0 °C(Predicted)
- 比重(密度) :
- 1.36±0.1 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- 0.1 M HCl: わずかに溶ける
- 外見 :
- 個体
- 酸解離定数(Pka):
- 11.24±0.20(Predicted)
- 色:
- ペールイエロー
3-[2-[4-ビス(4-フルオロフェニル)メチレンピペリジノ]エチル]-2,3-ジヒドロ-2-チオキソキナゾリン-4(1H)-オン 価格
もっと(2)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
Sigma-Aldrich Japan
|
D5794 |
ジアシルグリセロールキナーゼインヒビターII solid
Diacylglycerol Kinase Inhibitor II solid |
120166-69-0 |
1mg |
¥10200 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
D5794 |
ジアシルグリセロールキナーゼインヒビターII solid
Diacylglycerol Kinase Inhibitor II solid |
120166-69-0 |
5mg |
¥35400 |
2024-03-01 |
購入 |
3-[2-[4-ビス(4-フルオロフェニル)メチレンピペリジノ]エチル]-2,3-ジヒドロ-2-チオキソキナゾリン-4(1H)-オン 化学特性,用途語,生産方法
説明
R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC
50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. DGK-α inhibition with R-59-949 increases diacylglycerol-dependent PKC activity, serotonin secretion, and aggregation of thrombin-stimulated platelets. R-59-949 inhibits DGK-α activity induced by platelet-derived growth factor (PDGF) in intact vascular smooth muscle cells (VSMCs). It inhibits high K
+- and glucose-induced insulin secretion in MIN6 pancreatic β-cells in a dose-dependent manner.
In vivo, administration of R-59-949 prevents retinal neovascularization in a mouse model of oxygen-induced retinopathy.
使用
Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.
Biochem/physiol Actions
Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.
3-[2-[4-ビス(4-フルオロフェニル)メチレンピペリジノ]エチル]-2,3-ジヒドロ-2-チオキソキナゾリン-4(1H)-オン 上流と下流の製品情報
原材料
準備製品
3-[2-[4-ビス(4-フルオロフェニル)メチレンピペリジノ]エチル]-2,3-ジヒドロ-2-チオキソキナゾリン-4(1H)-オン 生産企業
Global( 44)Suppliers
120166-69-0(3-[2-[4-ビス(4-フルオロフェニル)メチレンピペリジノ]エチル]-2,3-ジヒドロ-2-チオキソキナゾリン-4(1H)-オン)キーワード:
- 120166-69-0
- DIACYLGLYCEROL KINASE INHIBITOR I (R59 949)
- DIACYLGLYCEROL KINASE INHIBITOR II
- R59949, 3-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
- 3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
- 3-[2-[4-(bis(4-Fluorophenyl)Methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, R59949
- DAG Kinase Inhibitor II
- DAG Kinase Inhibitor
- 3-[2-(4-[BIS(4-FLUOROPHENYL)-METHYLENE)-1-PIPERIDINYL)ETHYL]-2,3-DIHYDRO-2-THIOXO-4[1H]-QUINAZOLINONE
- R59949
- DIACYLGLYCEROL KINASE INHIBITOR II (R 59 949)
- 3-[2-[4-(bis(4-fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1h)-quinazolinone
- Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem
- 4(1H)-Quinazolinone, 3-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-
- Diacylglycerol Kinase Inhibitor II solid
- R-59949(R-59-949)
- 3-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one
- kinase,endogenous,PKC,plasma,platelet,diacylglycerol,Protein kinase C,Inhibitor,R59949,inhibit,ligand,membranes
- 3-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
- 3-[2-[4-ビス(4-フルオロフェニル)メチレンピペリジノ]エチル]-2,3-ジヒドロ-2-チオキソキナゾリン-4(1H)-オン
- ジアシルグリセロールキナーゼインヒビターII
- R-59949
- 3-(2-{4-[ビス(4-フルオロフェニル)メチリデン]ピペリジン-1-イル}エチル)-2-スルファニリデン-1,2,3,4-テトラヒドロキナゾリン-4-オン