DIACYLGLYCEROL KINASE INHIBITOR II
- CAS No.
- 120166-69-0
- Chemical Name:
- DIACYLGLYCEROL KINASE INHIBITOR II
- Synonyms
- R59949;R-59949(R-59-949);DAG Kinase Inhibitor;DAG Kinase Inhibitor II;DIACYLGLYCEROL KINASE INHIBITOR II;Diacylglycerol Kinase Inhibitor II solid;DIACYLGLYCEROL KINASE INHIBITOR I (R59 949);DIACYLGLYCEROL KINASE INHIBITOR II (R 59 949);Diacylglycerol Kinase Inhibitor II - CAS 120166-69-0 - Calbiochem;3-[2-[4-Bis(4-fluorophenyl)methylenepiperidino]ethyl]-2,3-dihydro-2-thioxoquinazolin-4(1H)-one
- CBNumber:
- CB4239260
- Molecular Formula:
- C28H25F2N3OS
- Molecular Weight:
- 489.58
- MDL Number:
- MFCD00069258
- MOL File:
- 120166-69-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H335-H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
DIACYLGLYCEROL KINASE INHIBITOR II price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | D5794 | Diacylglycerol Kinase Inhibitor II solid | 120166-69-0 | 1mg | $36.18 | 2024-03-01 | Buy |
Sigma-Aldrich | 266788 | Diacylglycerol Kinase Inhibitor II | 120166-69-0 | 5mg | $172 | 2024-03-01 | Buy |
Cayman Chemical | 21221 | R-59-949 ≥98% | 120166-69-0 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 21221 | R-59-949 ≥98% | 120166-69-0 | 5mg | $116 | 2024-03-01 | Buy |
Sigma-Aldrich | D5794 | Diacylglycerol Kinase Inhibitor II solid | 120166-69-0 | 5mg | $173 | 2024-03-01 | Buy |
DIACYLGLYCEROL KINASE INHIBITOR II Chemical Properties,Uses,Production
Description
R-59-949 is an inhibitor of diacylglycerol kinase α (DGK-α) with an IC50 value of 300 nM in isolated platelet plasma membranes using exogenous diacylglycerol as a substrate. DGK-α inhibition with R-59-949 increases diacylglycerol-dependent PKC activity, serotonin secretion, and aggregation of thrombin-stimulated platelets. R-59-949 inhibits DGK-α activity induced by platelet-derived growth factor (PDGF) in intact vascular smooth muscle cells (VSMCs). It inhibits high K+- and glucose-induced insulin secretion in MIN6 pancreatic β-cells in a dose-dependent manner. In vivo, administration of R-59-949 prevents retinal neovascularization in a mouse model of oxygen-induced retinopathy.
Uses
Diacylglycerol Kinase Inhibitor II has been used to determine tumor-induced inhibition with genetically modified cytotoxic T cells expressing chimeric antigen receptors (CAR). It has also been used to induce pAkt and PKR-like extracellular signal-regulated kinase (pErk) signals in T-cell acute lymphoblastic leukemia (T-ALL) cells.
Definition
ChEBI: 3-[2-[4-[bis(4-fluorophenyl)methylidene]-1-piperidinyl]ethyl]-2-sulfanylidene-1H-quinazolin-4-one is a diarylmethane.
Biochem/physiol Actions
Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.
DIACYLGLYCEROL KINASE INHIBITOR II Preparation Products And Raw materials
Raw materials
Preparation Products
DIACYLGLYCEROL KINASE INHIBITOR II Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9702 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9664 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
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