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N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド

N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド 化学構造式
915385-81-8
CAS番号.
915385-81-8
化学名:
N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド
别名:
N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド;(1s,3r,5R,7S)-3-(4-クロロフェニル)-N-[(ピリジン-4-イル)メチル]アダマンタン-1-カルボキサミド
英語名:
ABC294640
英語别名:
CS-802;ABC294640;ABC294640(Opaganib);Opaganib (ABC294640);3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide;3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide;Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl);3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide;ABC294640;ABC-294640;ABC 294640;3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE.;ABC294640; ABC-294640; ABC 294640; 3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE;OPAGANIB
CBNumber:
CB42624930
化学式:
C23H25ClN2O
分子量:
380.91
MOL File:
915385-81-8.mol

N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド 物理性質

沸点 :
589.5±50.0 °C(Predicted)
比重(密度) :
1.273±0.06 g/cm3(Predicted)
貯蔵温度 :
Inert atmosphere,Store in freezer, under -20°C
溶解性:
≥38.1 mg/mL in DMSO; insoluble in H2O; ≥58.9 mg/mL in EtOH
外見 :
solid
酸解離定数(Pka):
14.57±0.40(Predicted)

安全性情報

N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド 化学特性,用途語,生産方法

説明

ABC294640 is an inhibitor of sphingosine kinase 2 (SPHK2; Ki = 9.8 μM). It inhibits SPHK2 (IC50 = 60 μM) without affecting SPHK1 activity up to 100 μM but does reduce SPHK1 isoform a (SPHK1a) protein levels in androgen-independent LNCaP (LNCaP-AI) cells via an SPHK1-indirect, proteasomal-dependent mechanism when used at concentrations ranging from 5 to 25 μM. ABC294640 is inactive against a panel of 20 lipid-regulated kinases at 50 μM. It decreases sphingosine-1-phosphate (S1P) production in MDA-MB-231 cells in a concentration-dependent manner. ABC294640 inhibits proliferation of a variety of cancer cells, including HepG2 liver, A-498 kidney, PANC-1 pancreas, and HT-29 colon cells (IC50s = 6, 12.2, 32.8, and 48.1 μM, respectively). It reduces actin filament polymerization in, and cell migration of, A-498 cells in a scratch assay. Oral administration of ABC294640 (35 and 100 mg/kg every other day) reduces tumor growth in a mouse syngeneic model of mammary adenocarcinoma. It also reduces colonic inflammation in mouse and rat models of Crohn’s disease induced by trinitrobenzene sulfonic acid (TNBS).

使用

Opaganib is used in treating iatrogenic autoimmune colitis.

N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド 上流と下流の製品情報

原材料

4-ピコリルアミン

準備製品

N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド 生産企業

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N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド  スペクトルデータ(1HNMR)

ABC294640(915385-81-8)1HNMR

915385-81-8(N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド)キーワード:

アセトアニリド
  • 915385-81-8
  • ABC294640
  • 3-(4-Chlorophenyl)-N-(4-pyridinylmethyl)tricyclo[3.3.1.1(3,7)]decane-1-carboxamide
  • Tricyclo[3.3.1.13,7]decane-1-carboxamide, 3-(4-chlorophenyl)-N-(4-pyridinylmethyl)
  • ABC294640(Opaganib)
  • 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide
  • ABC294640; ABC-294640; ABC 294640; 3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE;OPAGANIB
  • CS-802
  • ABC294640;ABC-294640;ABC 294640;3-(4-CHLOROPHENYL)-ADAMANTANE-1-CARBOXYLIC ACID (PYRIDIN-4-YLMETHYL)AMIDE.
  • Opaganib (ABC294640)
  • 3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
  • N-[(4-ピリジニル)メチル]-3-(4-クロロフェニル)アダマンタン-1-カルボアミド
  • (1s,3r,5R,7S)-3-(4-クロロフェニル)-N-[(ピリジン-4-イル)メチル]アダマンタン-1-カルボキサミド
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